Abstract: The present invention is related to a pigment epithelium-derived factor (PEDF) for use in a method for treatment and/or prevention of dry macular degeneration in a subject, preferably dry age-related macular degeneration, wherein the method comprises administering PEDF and VEGF to the subject.

Abstract: The present invention relates to a compound and a pharmaceutical composition for use in the treatment and/or prophylaxis of a lipofuscin-associated disease and/or a disease associated with aged oxidized melanin of a living being. It also relates to a method for the production of a pharmaceutical composition for the treatment and/or prophylaxis of a lipofuscin-associated disease and/or a disease associated with aged oxidized melanin of a living being. It further relates to a compound for use in the removal of lipofuscin and/or aged oxidized melanin from a living being. It finally relates to a method for the therapeutic and/or prophylactic treatment of a living being affected by or suspected of being affected by a lipofuscin-associated disease and/or a disease associated with aged oxidized melanin.

Abstract: A method is described in which treatment is carried out with compounds of tetrahydropyridoethers that are administered in form of a medication to treat AMD and to remove lipofuscin from a patient's eye.

Abstract: The present invention is related to a pigment epithelium-derived factor (PEDF) for use in a method for treatment and/or prevention of a disease, wherein the method comprises administering PEDF to a subject, wherein the disease is an eye disease and wherein treatment and/or prevention of the disease comprises inhibiting labyrinth capillary formation, inducing growth of choriocapillaris, tightening choriocapillaris, inhibiting extracellular matrix formation, protecting choriocapillaris, and/or guiding vessel development.

Abstract: A method for selecting a compound or a composition suitable for treating lipofuscin associated diseases in a patient, the method including the steps of determining a reactivity factor, determining a targeting factor that allows an uptake into a cell and a provides a targeting of lipofuscin, and selecting a compound or a composition or combining compounds to obtain a compound or composition that comprises a reactivity factor and an targeting factor.

Abstract: A method for selecting a compound or a composition suitable for treating lipofuscin associated diseases in a patient, the method including the steps of determining a reactivity factor, determining a targeting factor that allows an uptake into a cell and a provides a targeting of lipofuscin, and selecting a compound or a composition or combining compounds to obtain a compound or composition that comprises a reactivity factor and an targeting factor.

Abstract: A medication comprising tetrahydropyridoethers for use in the treatment of AMD.

Abstract: A pharmaceutical composition comprising tetrahydropyridoethers for use in the treatment of Stargardt's disease.

Abstract: A medication comprising tetrahydropyridoethers for use in the treatment of AMD.

Abstract: A medication comprising tetrahydropyridoethers for use in the treatment of AMD.

Abstract: A medication comprising tetrahydropyridoethers for use in the treatment of AMD.

Abstract: The present invention relates to 5,6-dihydroxyindole (DHI), 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and/or 5-S-cysteinyldopa (CD) as medicaments, as well as their use, and the use of tyrosinase for the preparation of a medicament for prophylaxis or therapy of diseases induced by oxidative stress. Furthermore, the present invention relates to the use of gene therapy vectors comprising a tyrosinase gene. Further, the present invention relates to cells modified by a tyrosinase gene.

Abstract: The present invention relates to a pigment epithelial cell of the eye containing vector DNA of an adenoviral vector with large DNA capacity, to the improved isolation and cultivation of these cells and to methods for production and the use in the therapy of an eye or nerve disease.

Abstract: The present invention relates to a pigment epithelial cell of the eye containing vector DNA of an adenoviral vector with large DNA capacity, to the improved isolation and cultivation of these cells and to methods for production and the use in the therapy of an eye or nerve disease.

Abstract: The present invention relates to 5,6-dihydroxyindole (DHI), 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and/or 5-S-cysteinyldopa (CD) as medicaments, as well as their use, and the use of tyrosinase for the preparation of a medicament for prophylaxis or therapy of diseases induced by oxidative stress. Furthermore, the present invention relates to the use of gene therapy vectors comprising a tyrosinase gene. Further, the present invention relates to cells modified by a tyrosinase gene.

Abstract: The present invention relates to a pigment epithelial cell of the eye containing vector DNA of an adenoviral vector with large DNA capacity, to the improved isolation and cultivation of these cells and to methods for production and the use in the therapy of an eye or nerve disease.