Abstract: Methods for identifying biosynthetic gene clusters that include genes for producing compounds that interact with specific target proteins are disclosed. Some methods relate to bioinformatics methods for identifying and/or prioritizing biosynthetic gene clusters. Related systems, components, and tools for the identification and expression of such gene clusters are also disclosed.

Abstract: A multi-beam charged particle system and a method of setting a working distance WD of the multi beam charged particle system are provided. With the method, the working distance is adjusted while the imaging performance of a wafer inspection task is maintained by computing parameter values of components from predetermined calibration parameter values. The method can allow a relatively fast wafer inspection task even with a wafer stage with a fixed z-position parallel to an optical axis of the multi-beam charged particle system.

Abstract: A method for controlling an energy distribution introduced by at least one line focus of at least one laser beam in a substrate is performed by forming the line focus at least regionally in the substrate and influencing the laser beam with at least one phase mask to control the energy distribution in the substrate.

Abstract: A glass container is provided that includes a tube, a circular bottom, and a longitudinal axis. A curved glass heel extends from an outer end the bottom to the first end of the tube. The two-dimensional distance h(x,y) between a contact plane and the outer surface. The two-dimensional distance is measured in a direction parallel to the axis. The slope magnitude of the outer surface at the given position x,y is given by ?{square root over ((dh/dx)2+(dh/dy)2)}. The 75% quantile of values that have been determined for the term ?{square root over ((dh/dx)2+(dh/dy)2)}×d1/h(xy)delta for all given positions x,y within a circular area having a radius of 0.4×d2/2 and that correspond to the centre is less than 4100 ?m/mm. The adjacent positions x,y increase stepwise by 200 ?m, and h(x,y)delta=h(x,y)max?h(x,y)min, h(x,y)max is a maximum value for h(x,y) and h(x,y)min is a minimum value for h(x,y) being determined in that circular area.

Abstract: A platelike glass element is provided that includes a first surface, a second surface opposite the first, and a hole that perforates the first surface. The first surface has, at least partially around the hole, has a feature selected from a group consisting of: a height deviation with respect to the first surface that is greater than 0.005 ?m, is greater than 0.05 ?m, less than 0.1 ?m, less than 0.3 ?m, a less than 0.5 ?m, and combinations thereof. The first surface has an average roughness value that is less than 15 nm. The edge between the first surface and the hole that is free of elevations.

Abstract: A platelike glass element is provided that includes a first surface, a second surface opposite the first, and a hole that perforates the first surface. The hole extends in a longitudinal direction and a transverse direction, where the longitudinal direction is transverse to the first surface. The first surface has, at least partially around the hole, an elevation. The elevation has a feature selected from a group consisting of: a height of less than 5 ?m that at least partially around the hole, a height greater than 0.05 ?m, a height greater than 0.5 ?m, a height greater than 1 ?m, a height greater than 10 ?m, a height less than 20 ?m, a height less than 15 ?m, a height less than 12 ?m, and combinations thereof. The first surface has an average roughness value that is greater than 15 nm and less than 100 nm.

Abstract: An optical layered composite includes: a substrate having a front face, a back face, a thickness ds between the front face and the back face and a refractive index ns; and a coating applied to the front face. The coating comprises one or more coating layers. For at least one wavelength ?g in the range from 390 nm to 700 nm, the coating satisfies one of the following criterion: nc<ns; or nc>ns, and d c < k n c 2 - n s 2 · arctan ? n s 2 - 1 n c 2 - n s 2 ; nc is a mean refractive index of the coating layers, weighted by thickness; do is a total thickness of the coating; thicknesses are determined in a direction perpendicular to the front face; and k=?g/4?.

Abstract: A process for producing and/or checking an assembly of a substrate stack includes: planarly arranging at least one first substrate against a second substrate to form the substrate stack, the at least one first substrate and the second substrate being arranged directly against one another or on one another, so that at least one contact area is formed between the least one first substrate and the second substrate at which the at least one first substrate is in direct planar contact with the second substrate, the at least one first substrate including a transparent material; detecting a radiative reflection which comes about through irradiation of the substrate stack with a radiative input on the at least one contact area; and ascertaining a first bond quality index (Q1) of the contact area from the radiative reflection.

Abstract: The present disclosure provides a device and a method for laser-based separation of a transparent, brittle workpiece, comprising a laser that emits a laser beam having an intensity (IL) along an optical axis (P), and an optical device. The optical device has at least one one-piece double axicon. The double axicon has an entrance surface and the optical device has an exit surface. The entrance surface is such that in the double axicon, a ring beam is formed. The intensity (IL) in the double axicon is lower than the threshold intensity (IS) of the material of the double axicon. The exit surface is such that a line focus having a maximum intensity (Imax) and a length (LT) is generated in the direction of the laser beam behind the exit.

Abstract: A component of glass or glass ceramic having predamages arranged along at least one predetermined dividing line is provided. The dividing line has a row of predamages lying one behind the other. The predamages pass continuously through the glass or the glass ceramic with at least 90% of the predamages being cylindrically symmetrical. The glass or the glass ceramic has a material compaction of at least 1% relative to an actual material density in a radius of 3 ?m about a longitudinal axis of respective pre-damaged points. The relative weight loss per pre-damaged point is less than 10% and the component has a thickness of at least 3.5 mm.

Abstract: A glass article has a refractive index nG?1.95 and an R-number in a range of from 0.900 to 1.050. The R-number is calculated according to the following formula: R = ( n G - 1 ) ? ( ln [ ? G 2 - ? min 2 ? G 2 - ? max 2 · ? max 2 ? min 2 ] 42 ? ln [ ? B 2 - ? min 2 ? B 2 - ? max 2 · ? R 2 - ? max 2 ? R 2 - ? min 2 ] + 1 2.8 ) . ?R=656 nm, ?G=587 nm and ?B=486 nm, ?min=33 nm, and nG is a refractive index of the glass article at a wavelength of 587 nm.

Abstract: A hermetically sealed package includes: at least one cover substrate which is sheet-like and includes a flat outer surface and a circumferential narrow side, the at least one cover substrate being formed as a transparent thin film substrate, the at least one cover substrate having a thickness of less than 200 ?m; a second substrate which is adjoined to the at least one cover substrate and in direct contact with the at least one cover substrate; at least one functional area enclosed by the hermetically sealed package, the at least one functional area being between the at least one cover substrate and the second substrate; and a laser bonding line which joins the at least one cover substrate and the second substrate directly and in a hermetically tight manner.

Abstract: A component of glass or glass ceramic having predamages arranged along at least one predetermined dividing line is provided. The dividing line has a row of predamages lying one behind the other. The predamages pass continuously through the glass or the glass ceramic with at least 90% of the predamages being cylindrically symmetrical. The glass or the glass ceramic has a material compaction of at least 1% relative to an actual material density in a radius of 3 ?m about a longitudinal axis of respective pre-damaged points. The relative weight loss per pre-damaged point is less than 10% and the component has a thickness of at least 3.5 mm.

Abstract: The present disclosure relates to a layered optical composite, in particular for use in an augmented reality device. In particular, the disclosure relates to a layered optical composite and a process for its preparation, a device comprising the layered optical composite and a process for its preparation, and the use of a layered optical composite in an augmented reality device. The present disclosure relates to a layered optical composite comprising: a. a substrate having a front face and a back face, b. a coating comprising: i. a type T layer, and ii. a type C region comprising one or more type C layers; in which the substrate has: i. a thickness tG in the range from 0.2 to 1.2 mm; ii. a refractive index nG at a wavelength ? in the range from 1.6 to 2.4; and iii. an optical absorption coefficient KG at the wavelength ? of less than 10 cm?1; in which the type C layers individually and independently have: i. a thickness tC in the range from 9 to 250 nm; ii.

Abstract: A package for encapsulating a functional area against an environment includes a base substrate and a cover substrate, the base substrate together with the cover substrate defining at least part of the package or defining the package, and furthermore including the at least one functional area provided in the package, and a blocking way for reducing permeation between the environment and the functional area. The package may include at least one laser bonding line, and the substrates of the package can be hermetically joined to one another by the at least one laser bonding line, and the laser bonding line has a height (HL) perpendicular to its bonding plane.

Abstract: A method for providing a plurality of hermetically sealed packages, including the steps of: providing at least two substrates including a first substrate and a second substrate, at least one of the at least two substrates being a transparent substrate, the two substrates being arranged directly adjoining each other or on top of one another, the transparent substrate defining a circumferential rim and an upper side of each package, the bottom of the package being defined by the second substrate, a respective contact area being defined at contact surfaces between the two substrates; sealing each functional area in a hermetically tight manner by bonding the two substrates along the contact area of each package; and dicing each package by a cutting step or a separating step, a particle jet being used to abrasively remove a material from the transparent substrate by the particle jet.

Abstract: A substrate stack includes: at least two substrates including a base substrate and a cover substrate; at least one first laser weld line for welding the base substrate and the cover substrate; and at least one second beam spot or at least one second laser weld line at least one of situated next to the at least one first laser weld line or positioned such that a stress reduction in the at least one first laser weld line is achieved by the at least one second beam spot or second laser weld line, thus improving the mechanical stability of the substrate stack.

Abstract: A hermetically sealed package for thermal encapsulation of a functional area includes: a base substrate; a cover substrate, the base substrate together with the cover substrate forming at least part of the package or forming the package, at least one of the base substrate or the cover substrate being in the form of a thermal insulator; at least one functional area hermetically sealed by the package, heat can be generated inside the at least one functional area of the package; and at least one laser bonding line hermetically joining the base substrate and the cover substrate to one another. The at least one laser bonding line has a height perpendicular to its bonding plane.

Abstract: A hermetically sealed package includes: a heat-dissipating base substrate configured for dissipating heat from the hermetically sealed package; a cap arranged on the heat-dissipating base substrate, the cap and the heat-dissipating base substrate jointly forming at least a part of the package; at least one functional area hermetically sealed by the package; at least one laser bonding line configured for hermetically sealing the package, the laser bonding line having a height perpendicular to a bonding plane of the laser bonding line.

Abstract: A hermetically sealed package includes: at least one cover substrate and a substrate arranged so as to adjoin the at least one cover substrate, which together define at least part of the package, the at least one cover substrate being in a thermally prestressed state and bonded to the substrate adjoining the at least one cover substrate in a hermetically sealing manner by at least one laser bonding line, the at least one cover substrate being made of a material which has a different characteristic value of a coefficient of thermal expansion than the adjoining substrate and a thermal prestress is established in the package; and at least one functional area enclosed in the package.