Patents by Inventor Ulrike Bockau

Ulrike Bockau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System for the heterologous expression of a viral protein in a ciliate host cell
    Patent number: 8377682
    Abstract: The present invention relates to a system for the heterologous expression of a viral protein or a fragment thereof, said system comprising a) a ciliate host cell, b) at least one cDNA encoding for a viral protein, or a fragment thereof, and c) a promoter operably linked to said cDNA.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: February 19, 2013
    Assignee: Sanofi Pasteur S.A.
    Inventors: Marcus Hartmann, Christine Sachse, Jenny Apelt, Ulrike Bockau
  • Nucleic acid and its use effecting ciliate tetrahymena bifunctional dihydrofolate reductase-thymidylate synthase deficiency
    Patent number: 8114650
    Abstract: A method for producing a ciliate cell with reduced or essentially no dihydrofolate reductase (DHFS) activity or reduced or essentially no thymidylate synthase (TS) activity or both reduced or essentially no dihydrofolate reductase and thymidylate synthase (DHFR-TS) activity is claimed, comprising the steps of a) transforming ciliate cells by inserting a construct containing an allele altering the gene encoding the endogenous DHFR-TS into at least one of the endogenous DHFR-TS genes of the ciliate macronucleus (MAC), b) inducing an allelic assortment process in the transformed ciliate cells to generate cells having the construct inserted in most or all functional DHFR-TS genes of the MAC, and c) identifying the cells generated in step b) by cultivation with or without thymidine.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: February 14, 2012
    Assignee: Cilian AG
    Inventors: Thomas Weide, Ulrike Bockau, Marcus Hartmann, Lutz Herrmann
  • SYSTEM FOR THE HETEROLOGOUS EXPRESSION OF A VIRAL PROTEIN IN A CILIATE HOST CELL
    Publication number: 20110008835
    Abstract: The present invention relates to a system for the heterologous expression of a viral protein or a fragment thereof, said system comprising a) a ciliate host cell, b) at least one cDNA encoding for a viral protein, or a fragment thereof, and c) a promoter operably linked to said cDNA
    Type: Application
    Filed: June 16, 2010
    Publication date: January 13, 2011
    Inventors: Marcus Hartmann, Christine Sachse, Jenny Apelt, Ulrike Bockau
  • Tetrahymena bifunctional dihydrofolate reductase-thymidylate synthase deficiency and its use
    Publication number: 20100021952
    Abstract: A method for producing a ciliate cell with reduced or essentially no dihydrofolate reductase (DHFS) activity or reduced or essentially no thymidylate synthase (TS) activity or both reduced or essentially no dihydrofolate reductase and thymidylate synthase (DHFR-TS) activity is claimed, comprising the steps of a) transforming ciliate cells by inserting a construct containing an allele altering the gene encoding the endogenous DHFR-TS into at least one of the endogenous DHFR-TS genes of the ciliate macronucleus (MAC), b) inducing an allelic assortment process in the transformed ciliate cells to generate cells having the construct inserted in most or all functional DHFR-TS genes of the MAC, and c) identifying the cells generated in step b) by cultivation with or without thymidine.
    Type: Application
    Filed: September 20, 2006
    Publication date: January 28, 2010
    Inventors: Thomas Weide, Ulrike Bockau, Marcus Hartmann, Lutz Herrmann