Patents by Inventor Ulrike Leser-Reiff

Ulrike Leser-Reiff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and reagents for tissue engineering of cartilage in vitro
    Patent number: 7052514
    Abstract: The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: May 30, 2006
    Assignee: Curis, Inc.
    Inventors: Karin Kellner, Kurt Lang, Apollon Papadimitriou, Ulrike Leser-Reiff, Michaela Schultz, Torsten Blunk, Achim Goepferich
  • N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents
    Patent number: 6946462
    Abstract: New compounds represented by the formula or pharmaceutically acceptable salts or prodrugs thereof, wherein X1 and X2 are each independently selected from a CH group or a nitrogen atom; and R is an optionally substituted five or six membered nonaromatic carbocyclic ring or a nonaromatic or aromatic heterocyclic ring, whereby the ring is optionally condensed with a 6-membered, optionally substituted carbocyclic aromatic ring.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: September 20, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rainer Haag, Ulrike Leser-Reiff, Anja Limberg, Michael Weidner, Gerd Zimmermann
  • Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
    Patent number: 6890897
    Abstract: A melanoma inhibiting activity factor (MIA), preferably in combination with an osteoinductive protein, is a useful pharmaceutical agent for promoting bone healing and/or cartilage repair.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: May 10, 2005
    Assignee: Scil Technology GmbH
    Inventors: Carola Dony, Gabriele Proetzel, Ulrike Leser-Reiff
  • N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents
    Patent number: 6869953
    Abstract: New compounds represented by the formula or pharmaceutically acceptable salts or prodrugs thereof, wherein X1 and X2 are each independently selected from a CH group or a nitrogen atom; and R is an optionally substituted five or six membered nonaromatic carbocyclic ring or a nonaromatic or aromatic heterocyclic ring, whereby the ring is optionally condensed with a 6-membered, optionally substituted carbocyclic aromatic ring.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: March 22, 2005
    Assignee: Hoffman-La Roche Inc.
    Inventors: Rainer Haag, Ulrike Leser-Reiff, Anja Limberg, Michael Weidner, Gerd Zimmermann
  • Aromatic dicarboxylic acid derivatives
    Publication number: 20040214862
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: May 17, 2004
    Publication date: October 28, 2004
    Inventors: Ulrike Leser-Reiff, Tim Sattelkau, Gerd Zimmermann
  • N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents
    Publication number: 20040192744
    Abstract: New compounds represented by the formula 1
    Type: Application
    Filed: April 13, 2004
    Publication date: September 30, 2004
    Inventors: Rainer Haag, Ulrike Leser-Reiff, Anja Limberg, Michael Weidner, Gerd Zimmermann
  • Methods and compositions for regulating adiopocytes
    Publication number: 20040171533
    Abstract: The present application relates to a method for modulating the formation and/or maintenance of adipocyte tissue by ectopically contacting adipocyte cells, especially adipocyte stem/progenitor cells, in vitro or in vivo, with a hedgehog therapeutic or ptc therapeutic in an amount effective to alter the growth state the treated cells, e.g., relative to the absence of administeration of the hedgehog therapeutic or ptc therapeutic.
    Type: Application
    Filed: February 28, 2001
    Publication date: September 2, 2004
    Inventors: Barbara Zehentner, Ulrike Leser-Reiff, Helmut Burtscher
  • Aromatic dicarboxylic acid derivatives
    Patent number: 6784173
    Abstract: Compounds of formula I wherein A, R1 and R2 are defined in the specification. These compounds are useful as HDAC inhibitors. Also disclosed are methods of making and using said compounds.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: August 31, 2004
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulrike Leser-Reiff, Tim Sattelkau, Gerd Zimmermann
  • N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents
    Publication number: 20030139404
    Abstract: New compounds represented by the formula 1
    Type: Application
    Filed: August 6, 2002
    Publication date: July 24, 2003
    Inventors: Rainer Haag, Ulrike Leser-Reiff, Anja Limberg, Michael Weidner, Gerd Zimmermann
  • Aromatic dicarboxylic acid derivatives
    Publication number: 20030013757
    Abstract: Compounds of formula I 1
    Type: Application
    Filed: June 11, 2002
    Publication date: January 16, 2003
    Inventors: Ulrike Leser-Reiff, Tim Sattelkau, Gerd Zimmermann
  • Methods and reagents for tissue engineering of cartilage in vitro
    Publication number: 20020015719
    Abstract: The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.
    Type: Application
    Filed: April 27, 2001
    Publication date: February 7, 2002
    Inventors: Karin Kellner, Kurt Lang, Apollon Papadimitriou, Ulrike Leser-Reiff, Michaela Schultz, Torsten Blunk, Achim Goepferich