Patents by Inventor Ulysse Asseline

Ulysse Asseline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing hybridization complexes whose stability is substantially independent of the base composition of two hybridized nucleic acid molecules
    Patent number: 6864049
    Abstract: The invention discloses a method for producing a hybridization complex whose stability is substantially independent of the base composition of two hybridized nucleic acid molecules, consisting in contacting a first nucleic acid molecule with a second nucleic acid molecule under conditions enabling the formation of a specific hybridization complex. The invention is characterized in that at least one of the four types of bases contained in the sequence of the first and/or of the second nucleic acid molecule is a modified base having pairing properties close to those of the natural base it replaces, such that at least one of the two types of the base pair contained in the composition of the complex comprises a modified base and in that the totality of the base pairs contained in the composition of the said complex has a like stability.
    Type: Grant
    Filed: June 25, 1997
    Date of Patent: March 8, 2005
    Assignee: Appligene-Oncor S.A.
    Inventors: Thuong Nguyen, Ulysse Asseline, Hong Khanh Nguyen, Maurice Durand, Jean-Claude Maurizot, Daniel Dupret, Edwige Bonfils
  • Novel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis and their use
    Patent number: 4835263
    Abstract: The present invention relates to a chemical compound which consists of an oligonucleotide or an oligodeoxynucleotide consisting of a natural or modified chain of nucleotides (sic) to which an intercalating group is fixed via a covalent bond.
    Type: Grant
    Filed: December 18, 1986
    Date of Patent: May 30, 1989
    Assignee: Centre National De La Recherche Scientifique
    Inventors: Thanh T. Nguyen, Claude Helene, Ulysse Asseline