Patents by Inventor Uma Kotipalli

Uma Kotipalli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of Tasimelteon and intermediates thereof
    Patent number: 9944616
    Abstract: The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3) and (4) useful in the preparation of Tasimelteon (1).
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: April 17, 2018
    Assignee: Apotex Inc.
    Inventors: Yajun Zhao, Murali Kondamreddy, Peter Garth Blazecka, Gamini Weeratunga, Craig Stewart, Nalini Nagireddy, Michael B. Johansen, Uma Kotipalli
  • Salts of Prostaglandin Analog Intermediates
    Publication number: 20180016230
    Abstract: The present invention relates to crystalline 1-adamantanamine salts, and polymorphic forms thereof, of prostaglandin analog intermediates of formula 3a, 4a and 6a, useful in the preparation of Tafluprost and Lubiprostone and processes for their preparation. The process includes combining 1-adamantanamine, water, an organic solvent, and a compound of Formula 3 or 6, thereby obtaining a suspension. The process also includes isolating the solid salt of Formula 3a or 6a from the suspension.
    Type: Application
    Filed: December 10, 2015
    Publication date: January 18, 2018
    Inventors: Yajun Zhao, Yonggang Li, Uma Kotipalli, Sammy Chris Duncan, Honghai Lv, Kangying Li
  • Processes for the Preparation of Tasimelteon and Intermediates Thereof
    Publication number: 20170355688
    Abstract: The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3) and (4) useful in the preparation of Tasimelteon (1).
    Type: Application
    Filed: June 6, 2017
    Publication date: December 14, 2017
    Inventors: Yajun Zhao, Murali Kondamreddy, Peter Garth Blazecka, Gamini Weeratunga, Craig Stewart, Nalini Nagireddy, Michael B. Johansen, Uma Kotipalli
  • Processes for the preparation of 3-alkyl indoles
    Patent number: 9533949
    Abstract: This invention provides processes for preparation of 3-alkyl indoles of Formula 1: wherein A1, A2 and A3 are independently selected from the group consisting of: H, X, OR1, CN, CONR22 and C02R3; R1 is C1-C6 alkyl; R2 is H or C1-C6 alkyl; R3 is C1-C6 alkyl; LG is a leaving group; X is a halogen; and n is 1, 2 or 3.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: January 3, 2017
    Assignee: Apotex Pharmachem Inc.
    Inventors: Craig Stewart, Peter Garth Blazecka, Gamini Weeratunga, Uma Kotipalli, Sammy Chris Duncan, Yajun Zhao
  • Methods of making lubiprostone and intermediates thereof
    Patent number: 9382272
    Abstract: There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: July 5, 2016
    Assignee: Apotex Pharmachem Inc.
    Inventors: Kiran Kumar Kothakonda, Fan Wang, Bhaskar Reddy Guntoori, Minh T. N. Nguyen, Alfredo Paul Ceccarelli, Yajun Zhao, Uma Kotipalli, Sammy Chris Duncan, Kaarina K. Milnes, Kevin Wade Kells, Laura Kaye Montemayor
  • PROCESSES FOR THE PREPARATION OF 3-ALKYL INDOLES
    Publication number: 20150252000
    Abstract: This invention provides processes for preparation of 3-alkyl indoles of Formula 1: wherein A1, A2 and A3 are independently selected from the group consisting of: H, X, OR1, CN, CONR22 and C02R3; R1 is C1-C6 alkyl; R2 is H or C1-C6 alkyl; R3 is C1-C6 alkyl; LG is a leaving group; X is a halogen; and n is 1, 2 or 3.
    Type: Application
    Filed: September 12, 2013
    Publication date: September 10, 2015
    Inventors: Craig Stewart, Peter Garth Blazecka, Gamini Weeratunga, Uma Kotipalli, Sammy Chris Duncan, Yajun Zhao
  • Atorvastatin calcium propylene glycol solvates
    Patent number: 8188300
    Abstract: Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: May 29, 2012
    Assignee: Apotex Pharmachem Inc.
    Inventors: K.S. Keshava Murthy, Yajun Zhao, Allan W. Rey, Daqing Che, David A. Stradiotto, Uma Kotipalli
  • METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF
    Publication number: 20120065409
    Abstract: There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds.
    Type: Application
    Filed: January 22, 2010
    Publication date: March 15, 2012
    Applicant: APOTEX PHARMACHEM INC.
    Inventors: Kiran Kumar Kothakonda, Fan Wang, Bhaskar Reddy Guntoori, Minh T. N. Nguyen, Alfredo Paul Ceccarelli, Yajun Zhao, Uma Kotipalli, Sammy Chris Duncan, Kaarina K. Milnes, Kevin Wade Kells, Laura Kaye Montemayor
  • ATORVASTATIN CALCIUM PROPYLENE GLYCOL SOLVATES
    Publication number: 20110065931
    Abstract: Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications.
    Type: Application
    Filed: November 15, 2010
    Publication date: March 17, 2011
    Applicant: APOTEX PHARMACHEM INC.
    Inventors: K.S. Keshava Murthy, Yajun Zhao, Allan W. Rey, Daqing Che, David A. Stradiotto, Uma Kotipalli
  • Atorvastatin calcium propylene glycol solvates
    Patent number: 7834195
    Abstract: Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: November 16, 2010
    Assignee: Apotex Pharmachem Inc.
    Inventors: K. S. Keshava Murthy, Yajun Zhao, Allan W. Rey, Daqing Che, David A. Stradiotto, Uma Kotipalli
  • Atorvastatin calcium propylene glycol solvates
    Publication number: 20080177087
    Abstract: Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications.
    Type: Application
    Filed: June 14, 2007
    Publication date: July 24, 2008
    Inventors: K.S. Keshava Murthy, Yajun Zhao, Allan W. Rey, Daqing Che, David A. Stradiotto, Uma Kotipalli