Patents by Inventor Umar S. M. Maharoof

Umar S. M. Maharoof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHENYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
    Publication number: 20120302569
    Abstract: This invention relates to phenyl thiazole I and its therapeutic and prophylactic uses, wherein the variables Rz, Q, J, R1, R3, R5, R6, and R7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
    Type: Application
    Filed: May 24, 2012
    Publication date: November 29, 2012
    Inventors: Paul Francis JACKSON, Kristi Anne Leonard, Joseph Kent Barbay, Aihua Wang, Brett Andrew Tounge, Yan Zhang, Umar S.M. Maharoof
  • Piperidinyl and piperazinyl modulators of ?-secretase
    Patent number: 8252935
    Abstract: The present invention relates to compounds of Formula I as shown below, wherein the definitions of Het, R0, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with ?-secretase activity, including Alzheimer's disease.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: August 28, 2012
    Assignees: Janssen Pharmaceutica N.V., Cellzome Limited
    Inventors: Chih Yung Ho, Yan Zhang, Umar S. M. Maharoof, Jeremy Major, John Harrison
  • Amine linked modulators of ?-secretase
    Patent number: 8247610
    Abstract: The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, Y, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with ?-secretase activity, including Alzheimer's disease.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: August 21, 2012
    Assignees: Janssen Pharmaceutica N.V., Cellzome Limited
    Inventors: Chih Yung Ho, Yan Zhang, Umar S. M. Maharoof, John Harrison, Jeremy Major, Svenja Burckhardt, Alison Jones
  • PYRIDYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
    Publication number: 20120129843
    Abstract: This invention relates to thiazole I and its therapeutic and prophylactic uses, wherein the variables Rz, Q, J, R1, R3, R5, and R6 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 24, 2012
    Inventors: Yan ZHANG, Brett Andrew Tounge, Aihua Wang, Michael Hawkins, Kristi Anne Leonard, Joseph Kent Barbay, Umar S.M. Maharoof
  • BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
    Publication number: 20120129842
    Abstract: This invention relates to bisthiazole I and its therapeutic and prophylactic uses, wherein the variables A, R5, R6, and R7 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 24, 2012
    Inventors: Paul Francis JACKSON, Brett Andrew Tounge, Kristi Anne Leonard, Yan Zhang, Aihua Wang, Michael Hawkins, Umar S.M. Maharoof, Joseph Kent Barbay
  • BIS HETEROARYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
    Publication number: 20120129897
    Abstract: This invention relates to thiazole I and its therapeutic and prophylactic uses, wherein the variables A, Q, J, R1, R3, and R5 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 24, 2012
    Inventors: Joseph Kent Barbay, Kristi Anne Leonard, Yan Zhang, Brett Andrew Tounge, Aihua Wang, Michael Hawkins, Paul Francis Jackson, Umar S.M. Maharoof
  • TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
    Publication number: 20120129811
    Abstract: This invention relates to tricycle I and its therapeutic and prophylactic uses, wherein the variables C1, C2, Z1, Z2, Q, J, R1, and R3 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 24, 2012
    Inventors: Aihua WANG, Yan Zhang, Kristi Anne Leonard, Michael Hawkins, Brett Andrew Tounge, Umar S.M. Maharoof, Joseph Kent Barbay
  • FUSED HETEROARYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION
    Publication number: 20120129872
    Abstract: This invention relates to thiazole I and its therapeutic and prophylactic uses, wherein the variables A, Q, J, R1, R3, and R5 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 24, 2012
    Inventors: Kristi Anne Leonard, Yan Zhang, Brett Andrew Tounge, Aihua Wang, Michael Hawkins, Paul Francis Jackson, Joseph Kent Barbay, Umar S.M. Maharoof
  • N-substituted tricyclic 3-aminopyrazoles as anti-mitotic tubulin polymerization inhibitors
    Patent number: 7816390
    Abstract: The invention is directed to compounds having the following structures: N-(3-ethoxyphenyl)-1,4-dihydro-6-ethoxy-7-(3-hydroxypropoxy)-1-methylindeno[1,2-c]pyrazole-3-amine; 3-[3-(3-Bromo-phenylamino)-6-ethoxy-1-methyl-1,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol; or 3-[3-(2-Chloro-pyridin-4-ylamino)-6-ethoxy-1-methyl-1,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol, and N-oxides, pharmaceutically acceptable salts, solvates, tautomers and stereochemical isomers thereof and the uses of such compounds as inhibitors of tubulin polymerization and for the treatment of solid tumors. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: October 19, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Robert A. Galemmo, Dana L. Johnson, Umar S. M. Maharoof, Jay M. Mei, Robert W. Tuman
  • N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS ANTI-MITOTIC TUBULIN POLYMERIZATION INHIBITORS
    Publication number: 20080227821
    Abstract: The invention is directed to compounds having the following structures: N-(3-ethoxyphenyl)-1,4-dihydro-6-ethoxy-7-(3-hydroxypropoxy)-1-methylindeno[1,2-c]pyrazole-3-amine; 3-[3-(3-Bromo-phenylamino)-6-ethoxy-1-methyl-1,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol; or 3-[3-(2-Chloro-pyridin-4-ylamino)-6-ethoxy-1-methyl-1,4-dihydro-indeno[1,2-c]pyrazol-7-yloxy]-propan-1-ol, and N-oxides, pharmaceutically acceptable salts, solvates, tautomers and stereochemical isomers thereof and the uses of such compounds as inhibitors of tubulin polymerization and for the treatment of solid tumors. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
    Type: Application
    Filed: January 29, 2008
    Publication date: September 18, 2008
    Inventors: Robert A. Galemmo, Dana L. Johnson, Umar S.M. Maharoof, Jay M. Mei, Robert W. Tuman