Patents by Inventor Umashankar Das

Umashankar Das has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiparasitic effect of Bis[3,5-Bis(Benzylidene)-4-Oxo-1-Piperidinyl]amide Derivatives
    Patent number: 9669016
    Abstract: Embodiments are directed to compositions and methods for treating parasitic infections. Compounds have been identified from a library of anti-cancer drugs that serve as suitable agents for targeting trypanosomatids.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: June 6, 2017
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, UNIVERSITY OF SASKATCHEWAN
    Inventors: Rosa A. Maldonado, Miguel A. Vasquez, Jonathan R. Dimmock, Umashankar Das
  • Antiparasitic Effect of Bis[3,5-Bis(Benzylidene)-4-Oxo-1-Piperidinyl]amide Derivatives
    Publication number: 20160303105
    Abstract: Embodiments are directed to compositions and methods for treating parasitic infections. Compounds have been identified from a library of anti-cancer drugs that serve as suitable agents for targeting trypanosomatids.
    Type: Application
    Filed: June 27, 2016
    Publication date: October 20, 2016
    Inventors: Rosa A. MALDONADO, Miguel A. VASQUEZ, Jonathan R. DIMMOCK, Umashankar DAS
  • ANTIPARASITIC EFFECT OF BIS[3,5-BIS(BENZYLIDENE)-4-OXO-1-PIPERIDINYL]AMIDE DERIVATIVES
    Publication number: 20150290183
    Abstract: Embodiments are directed to compositions and methods for treating parasitic infections. Compounds have been identified from a library of anti-cancer drugs that serve as suitable agents for targeting trypanosomatids.
    Type: Application
    Filed: April 10, 2015
    Publication date: October 15, 2015
    Inventors: Rosa A. Maldonado, Miguel A. Vasquez, Jonathan R. Dimmock, Umashankar Das
  • Antineoplastic compounds
    Patent number: 7582655
    Abstract: The present invention relates to 4-piperidone derivatives represented by the following formula (I) and the acid addition salts thereof. The method of preparation and antineoplastic activity of the said compounds are disclosed. A number of the compounds possess submicromolar IC50 and CC50 values and have a selective toxicity for colon cancers and leukemic cells. In addition, many of the compounds are able to reverse multidrug resistance.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: September 1, 2009
    Assignee: University of Saskatchewan
    Inventors: Jonathan R. Dimmock, Umashankar Das
  • ANTINEOPLASTIC COMPOUNDS
    Publication number: 20070155733
    Abstract: The present invention relates to 4-piperidone derivatives represented by the following formula (I) and the acid addition salts thereof. The method of preparation and antineoplastic activity of the said compounds are disclosed. A number of the compounds possess submicromolar IC50 and CC50 values and have a selective toxicity for colon cancers and leukemic cells. In addition, many of the compounds are able to reverse multidrug resistance.
    Type: Application
    Filed: November 22, 2006
    Publication date: July 5, 2007
    Applicant: UNIVERSITY OF SASKATCHEWAN
    Inventors: Jonathan DIMMOCK, Umashankar DAS
  • Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-?, ?-dimethylphenylacetic acid
    Patent number: 6903232
    Abstract: This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula II is decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: June 7, 2005
    Assignee: Aurobindo Pharma Ltd.
    Inventors: Ramesh Dandala, Umashankar Das, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran
  • Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-alpha, alpha-dimethylphenylacetic acid
    Publication number: 20040077900
    Abstract: This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl) -&agr;, &agr;-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-&agr;,&agr;-dimethylphenylacetic acid of Formula 11 1
    Type: Application
    Filed: July 2, 2003
    Publication date: April 22, 2004
    Inventors: Ramesh Dandala, Umashankar Das, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran