Patents by Inventor Umberto Breme

Umberto Breme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Paclitaxel production by actinomycetes
    Patent number: 6528301
    Abstract: The present invention related to microorganisms producing taxanes, such as paclitaxel or related taxanes, to the use of said microorganisms for the production of taxanes, and to the procedure for the isolation of said microorganisms from plants. In particular, the present invention relates to microorganisms of the Actinomycetes group producing taxanes as well as to the biologically pure cultures of a strain of the Actinomycetes group which produces taxanes. The microorganisms of Actinomycetes group are preferably belonging to the suprageneric groups of Streptomycetes, Actinoplanetes, Maduromycetes, Thermomonosporas or Nocardioforms, more preferably they are belonging to genus Streptomyces, Actinoplanes, Nocardiopsis, Micromonospora, Actinomadura or Kitasatosporia, still more preferably to the genus Kitasatosporia. A particularly preferred microorganism is Kitasatosporia sp. CECT 4991.
    Type: Grant
    Filed: August 21, 2000
    Date of Patent: March 4, 2003
    Assignee: Pharmacia & Upjohn SpA
    Inventors: Umberto Breme, Marinella Caruso, Nicoletta Crespi Perellino, Lorena Fedeli, Andrea Pavesi, Luca Piacenza, Giambattista Ventrella
  • Process for preparing doxorubicin
    Patent number: 6210930
    Abstract: The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism is mutated. The mutated gene is preferably dnrU and/or dnrX.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: April 3, 2001
    Assignee: Pharmacia & Upjohn, S.P.A.
    Inventors: Silvia Filippini, Natalia Lomovskaya, Leonid Fonstein, Anna Luisa Colombo, C. Richard Hutchinson, Sharee L. Otten, Umberto Breme
  • Anthracycline glycosides
    Patent number: 6187758
    Abstract: An anthracycline glycoside of formula I wherein R is one of the two following residues: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: February 13, 2001
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Cinzia Portello, Emanuele Arlandini, Umberto Breme, Anna Luisa Colombo, Giuliano Franchi, Giuliano Oronzo, Marco Tató, Luisa Garofano, Marina Ciomei
  • Process for preparing doxorubicin
    Patent number: 5955319
    Abstract: The present invention concerns a process for improving doxorubicin production by means of a recombinant Streptomyces peucetius strain bearing a mutation in the gene dnrU coding for a protein involved in the metabolism of daunorubicin.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: September 21, 1999
    Assignee: Pharmacia & Upjohn, S.p.A.
    Inventors: Silvia Filippini, Umberto Breme, Anna Luisa Colombo, Natasha Lomovskaya, Leonid Fonstein, Sharee Otten, Charles R. Hutchinson
  • Daunorubin 14-hydroxylase
    Patent number: 5786190
    Abstract: The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: July 28, 1998
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Augusto Solari Inventi, Umberto Breme, Anna Luisa Colombo, Charles Richard Hutchinson, Sharee Otten, Claudio Scotti
  • DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
    Patent number: 5695966
    Abstract: The ability to convert daunorubicin to doxorubicin can be conferred on a host cell by transformation with a recombinant vector comprising DNA encoding daunorubicin 14-hydroxylase. The host cell can then be used to produce doxorubicin.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: December 9, 1997
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Augusto Solari Inventi, Umberto Breme, Anna Luisa Colombo, Charles Richard Hutchinson, Sharee Otten, Claudio Scotti