Patents by Inventor Umberto Ciambecchini
Umberto Ciambecchini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9272982Abstract: A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.Type: GrantFiled: June 19, 2014Date of Patent: March 1, 2016Assignee: CHEMI S.P.A.Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
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Patent number: 9206229Abstract: Bortezomib esters with tartaric acid wherein the molar ratio between bortezomib and tartaric acid is 2:1 and formulations containing them are described.Type: GrantFiled: August 1, 2013Date of Patent: December 8, 2015Assignee: CHEMI S.P.A.Inventors: Stefano Turchetta, Maurizio Zenoni, Umberto Ciambecchini, Paolo Brandi, Vincenzo De Sio, Giorgio Berardi
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Publication number: 20150232508Abstract: Bortezomib esters with tartaric acid wherein the molar ratio between bortezomib and tartaric acid is 2:1 and formulations containing them are described.Type: ApplicationFiled: August 1, 2013Publication date: August 20, 2015Inventors: Stefano Turchetta, Maurizio Zenoni, Umberto Ciambecchini, Paolo Brandi, Vincenzo De Sio, Giorgio Berardi
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Patent number: 9096491Abstract: A process for the preparation of a prodrug of 5-aminosalicylic acid, namely 2-butanoyloxy-5-amino-benzoic acid, and solid forms of such compound are described.Type: GrantFiled: July 9, 2012Date of Patent: August 4, 2015Assignee: CHEMI S.P.A.Inventors: Maurizio Zenoni, Umberto Ciambecchini, Lorenzo De Ferra, Stefano Turchetta, Vincenzo De Sio
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Patent number: 8981090Abstract: The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps: a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2.Type: GrantFiled: July 5, 2011Date of Patent: March 17, 2015Assignee: Chemi S.p.A.Inventors: Umberto Ciambecchini, Stefano Turchetta, Maurizio Zenoni, Lorenzo De Ferra, Paolo Brandi
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Patent number: 8946456Abstract: The present invention regards an improved and industrially advantageous process for the preparation of the 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called “feso chromenyl” and (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, also called “(R)-feso deacyl”, which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine fumarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate “(R)-feso deacyl”, called form B.Type: GrantFiled: April 29, 2011Date of Patent: February 3, 2015Assignee: Chemi S.p.A.Inventors: Umberto Ciambecchini, Stefano Turchetta, Lorenzo De Ferra, Maurizio Zenoni
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Publication number: 20140303396Abstract: A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.Type: ApplicationFiled: June 19, 2014Publication date: October 9, 2014Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
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Publication number: 20140163251Abstract: A process for the preparation of a prodrug of 5-aminosalicylic acid, namely 2-butanoyloxy-5-amino-benzoic acid,and solid forms of such compound are described.Type: ApplicationFiled: July 9, 2012Publication date: June 12, 2014Applicant: CHEMI S.P.A.Inventors: Maurizio Zenoni, Umberto Ciambecchini, Lorenzo De Ferra, Stefano Turchetta, Vincenzo De Sio
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Patent number: 8445716Abstract: A process is described for preparing fesoterodine and/or fesoterodine fumarate comprising the esterification of (R)-feso deacyl with isobutyric acid or a precursor thereof, such as an isobutyryl halide or the isobutyric acid anhydride to give fesoterodine, in a mixture of water at alkaline pH and/or at least one organic solvent. This process allows obtaining products with high yields and purities, and in particular a product having a content of (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-isobutyroyloxymethyl-phenyl isobutyrate less than 1% by mole and a content of (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol less than 0.05% by mole.Type: GrantFiled: May 13, 2010Date of Patent: May 21, 2013Assignee: Chemi S.p.A.Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
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Publication number: 20130079532Abstract: The present invention regards an improved and industrially advantageous process for the preparation of the 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called “feso chromenyl” and (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, also called “(R)-feso deacyl”, which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine fumarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate “(R)-feso deacyl”, called form B.Type: ApplicationFiled: April 29, 2011Publication date: March 28, 2013Applicant: CHEMI S.P.A.Inventors: Umberto Ciambecchini, Stefano Turchetta, Lorenzo De Ferra, Maurizio Zenoni
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Publication number: 20120172595Abstract: The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps: a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2.Type: ApplicationFiled: July 5, 2011Publication date: July 5, 2012Applicant: CHEMI S.P.A.Inventors: Umberto CIAMBECCHINI, Stefano TURCHETTA, Maurizio ZENONI, Lorenzo DE FERRA, Paolo BRANDI
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Patent number: 8049031Abstract: New solid forms of fesoterodine fumarate are described. In particular, amorphous fesoterodine fumarate, characterized by a powder X-ray diffraction spectrum as shown in FIG. 1 and by an IR spectrum as shown in FIG. 2 is described. Also fesoterodine fumarate in crystalline form I, characterized by a powder X-ray diffraction spectrum as shown in FIG. 3, by a DSC profile as shown in FIG. 4, by an IR spectrum as shown in FIG. 5, by a solid state 13C-NMR spectrum as shown in FIG. 6 and by a Raman spectrum as shown in FIGS. 7, 8 and 9 is described.Type: GrantFiled: December 10, 2009Date of Patent: November 1, 2011Assignee: Chemi S.p.A.Inventors: Umberto Ciambecchini, Maurizio Zenoni, Stefano Turchetta
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Patent number: 7858634Abstract: A process for the preparation of 3-pyridil-1-hydroxyethyliden-1,1-biphosphonic acid monosodium salt of formula in an amorphous form, preferably lyophilized, and its pharmaceutical compositions are described. Said amorphous form, characterized by stability and simplicity of preparation and formulation, can be obtained by an industrially applicable lyophilization process, which comprises the steps of: a) dissolving or suspending 3-pyridyl-1-hydroxyethyliden-1,1-biphosphonic acid in an aqueous solvent, b) adding one equivalent of a base having sodium as cation c) subjecting the solution to lyophilization.Type: GrantFiled: February 28, 2005Date of Patent: December 28, 2010Assignee: Chemi SpAInventors: Stefano Turchetta, Pietro Massardo, Umberto Ciambecchini
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Publication number: 20100292502Abstract: A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.Type: ApplicationFiled: May 13, 2010Publication date: November 18, 2010Applicant: CHEMI S.P.A.Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
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Publication number: 20100292503Abstract: A process is described for preparing fesoterodine and/or fesoterodine fumarate comprising the esterification of (R)-feso deacyl with isobutyric acid or a precursor thereof, such as an isobutyryl halide or the isobutyric acid anhydride to give fesoterodine, in a mixture of water at alkaline pH and/or at least one organic solvent. This process allows obtaining products with high yields and purities, and in particular a product having a content of (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-isobutyroyloxymethyl-phenyl isobutyrate less than 1% by mole and a content of (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol less than 0.05% by mole.Type: ApplicationFiled: May 13, 2010Publication date: November 18, 2010Applicant: CHEMI S.P.A.Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
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Publication number: 20100152483Abstract: New solid forms of fesoterodine fumarate are described. In particular, amorphous fesoterodine fumarate, characterised by a powder X-ray diffraction spectrum as shown in FIG. 1 and by an IR spectrum as shown in FIG. 2 is described. Also fesoterodine fumarate in crystalline form I, characterised by a powder X-ray diffraction spectrum as shown in FIG. 3, by a DSC profile as shown in FIG. 4, by an IR spectrum as shown in FIG. 5, by a solid state 13C-NMR spectrum as shown in FIG. 6 and by a Raman spectrum as shown in FIGS. 7, 8 and 9 is described.Type: ApplicationFiled: December 10, 2009Publication date: June 17, 2010Applicant: CHEMI S.P.A.Inventors: Umberto Ciambecchini, Maurizio Zenoni, Stefano Turchetta
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Patent number: 7358399Abstract: A process is described for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine comprising substitution of the sulfonyloxy group of the compound of the formula in which the substituents R and R? have the meanings stated in the description, in a solvent comprising an ionic liquid, to yield the tertiary amine of the formula and the subsequent deprotection thereof.Type: GrantFiled: October 6, 2005Date of Patent: April 15, 2008Assignee: Chemi SPAInventors: Stefano Turchetta, Umberto Ciambecchini, Pietro Massardo
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Publication number: 20060079716Abstract: A process is described for the preparation of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propaneamine comprising substitution of the sulfonyloxy group of the compound of the formula in which the substituents R and R? have the meanings stated in the description, in a solvent comprising an ionic liquid, to yield the tertiary amine of the formula and the subsequent deprotection thereof.Type: ApplicationFiled: October 6, 2005Publication date: April 13, 2006Applicant: CHEMI SPAInventors: Stefano Turchetta, Umberto Ciambecchini, Pietro Massardo
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Publication number: 20050215793Abstract: A process for the preparation of 3-pyridil-1-hydroxyethyliden-1,1-biphosphonic acid monosodium salt of formula in an amorphous form, preferably lyophilized, and its pharmaceutical compositions are described.Type: ApplicationFiled: February 28, 2005Publication date: September 29, 2005Applicant: CHEMI SPAInventors: Stefano Turchetta, Pietro Massardo, Umberto Ciambecchini