Patents by Inventor Umberto Guzzi

Umberto Guzzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 4-substituted tetrahydropyridines for the manufacture of medicaments acting upon TGF-? 1
    Patent number: 7320982
    Abstract: The invention relates to the use of a compound of formula (I): for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-?1.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: January 22, 2008
    Assignee: sanofi-aventis
    Inventors: Françoise Bono-Combie, Jacqueline Fournier, Jean Marc Herbert, Isabelle Lamarche, Umberto Guzzi
  • Preparation of benzoylalkyl-1,2,3,6-tetrahydropyridines and use thereof
    Patent number: 7297799
    Abstract: The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: November 20, 2007
    Assignee: Sanofi-Aventis
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • PREPARATION OF BENZOYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES AND USE THEREOF
    Publication number: 20070054931
    Abstract: The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
    Type: Application
    Filed: November 1, 2006
    Publication date: March 8, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
    Patent number: 7151107
    Abstract: The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: December 19, 2006
    Assignee: Sanofi-aventis
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
    Publication number: 20050222187
    Abstract: The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
    Type: Application
    Filed: May 24, 2005
    Publication date: October 6, 2005
    Applicant: Sanofi-Aventis
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
    Patent number: 6936621
    Abstract: The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: August 30, 2005
    Assignee: Sanofi-Aventis
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • Use of 4-substituted tetrahydropyridines for the manufacture of medicaments acting upon TGF-beta 1
    Publication number: 20040157868
    Abstract: The invention relates to the use of a compound of formula (I): 1
    Type: Application
    Filed: February 5, 2004
    Publication date: August 12, 2004
    Inventors: Francoise Bono-Combie, Jacqueline Fournier, Jean Marc Herbert, Isabelle Lamarche, Umberto Guzzi
  • Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
    Publication number: 20040122032
    Abstract: The invention relates to the use of compounds of formula 1
    Type: Application
    Filed: December 5, 2003
    Publication date: June 24, 2004
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • Use of 4-substituted tetrahydropyridines for the manufacture of medicaments acting upon TGF-&bgr;1
    Patent number: 6693118
    Abstract: The invention relates to the use of a compound of formula (I): for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-&bgr;1.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: February 17, 2004
    Assignee: Sanofi-Synthelabo
    Inventors: Françoise Bono-Combie, Jacqueline Fournier, Jean Marc Herbert, Isabelle Lamarche, Umberto Guzzi
  • Phenoxylpropanolamines, method for the production thereof and pharmaceutical compositions containing the same
    Patent number: 6649627
    Abstract: The invention concerns compounds of formula (Ia) wherein R1a represents hydrogen, an —S(O)z —(C1-C4)Alk group, a —CO(C1-C4)Alk group, an —NHSO2—(C1-C4)Alk group, an NCHl (C1-C4) Alk group, a 2-furyl group or a halogen; R2 represents hydrogen or a (C1-C4)Alk group, a (C1-C4) alkoxyl group, a halogen, —COOH, —COO(C1-C4)Alk, —CN, —CONR3R4, —NO2, —SO2NH2, —NHSO2(C1-C4)Alk; m and n are independently 0, 1 or 2; R3 and R4 independently represent hydrogen or a (C1-C4)Alk group; Z is 1 or 2 and their salts or solvates, the pharmaceutical compositions that contain them, the process for their preparation, and intermediate synthesis products.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: November 18, 2003
    Assignee: Sanofi-Synthelabo
    Inventors: Roberto Cecchi, Tiziano Croci, Umberto Guzzi, Eric Marsault
  • Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity
    Patent number: 6509351
    Abstract: The present invention relates to compounds of formula (I): as well as the salts or solvates thereof, to pharmaceutical compositions containing them, to a process for preparing them and to synthetic intermediates in this process.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: January 21, 2003
    Assignee: Sanofi-Syntelabo
    Inventors: Marco Baroni, Bernard Bourrie, Rosanna Cardamone, Pierre Casellas, Umberto Guzzi
  • Use of 4-substituted tetrahydropyridines for the manufacture of medicament s acting upon TGF-beta 1
    Publication number: 20020091143
    Abstract: The invention relates to the use of a compound of formula (I): 1
    Type: Application
    Filed: November 20, 2001
    Publication date: July 11, 2002
    Inventors: Francoise Bono-Combie, Jacqueline Fournier, Jean Marc Herbert, Isabelle Lamarche, Umberto Guzzi
  • Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
    Publication number: 20020058672
    Abstract: The invention relates to the use of compounds of formula 1
    Type: Application
    Filed: November 20, 2001
    Publication date: May 16, 2002
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • Use of benzoylalkyl-1,2,3,6-tetrahydropyridines
    Patent number: 6358965
    Abstract: The invention relates to the use of compounds of formula for the preparation of medicines designed for the treatment of neuronal and cerebral disorders. The invention also relates to the compounds of formula: a process for their preparation and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: March 19, 2002
    Assignee: Sanofi-Synthelabo
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • Use of 4-substituted tetrahydropyridines for making medicines acting on TGF-&bgr;1
    Patent number: 6342505
    Abstract: The invention relates to the use of a compound of formula (I): for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-&bgr;1.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: January 29, 2002
    Assignee: Sanofi-Synthelabo
    Inventors: Françoise Bono-Combie, Jacqueline Fournier, Jean Marc Herbert, Isabelle Lamarche, Umberto Guzzi
  • Diphenylalkyl-tetrahydropyridines, process for their preparation, and pharmaceutical compositions containing them
    Patent number: 6124318
    Abstract: The invention relates to compounds of the formula ##STR1## in which: Y is --CH-- or --N--;R.sub.1 is a halogen or a CF.sub.3, (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group;R.sub.2 and R.sub.3 are each hydrogen or a (C.sub.1 -C.sub.3)alkyl;n is 0 or 1; andPh.sub.1 and Ph.sub.2 are each independently an unsubstituted, monosubstituted or polysubstituted phenyl group;to a process for their preparation and to the pharmaceutical compositions containing them.These compounds have neurotrophic and neuroprotective activity.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: September 26, 2000
    Assignee: Sanofi-Synthelabo
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi
  • 1-Phenylalkyl-1,2,3,6-tetrahydropyridines for treating Alzheimer's disease
    Patent number: 6034090
    Abstract: The invention relates to compounds of the formula in which: Y is --CH-- or --N--; R.sub.1 is hydrogen, a halogen or a CF.sub.3, (C.sub.1 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group; R.sub.2 is a methyl or ethyl group; R.sub.3 and R.sub.4 are each hydrogen or a (C.sub.1 -C.sub.3)alkyl; and X is:(a) a (C.sub.1 -C.sub.6)alkyl, a (C.sub.1 -C.sub.6)alkoxy, a (C.sub.3 -C.sub.7)carboxyalkyl, a (C.sub.1 -C.sub.4)alkoxy-carbonyl(C.sub.1 -C.sub.6)alkyl, a (C.sub.3 -C.sub.7)carboxyalkoxy or a (C.sub.1 -C.sub.4)alkoxycarbonyl-(C.sub.1 -C.sub.6)alkoxy;(b) a radical selected from (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkoxy, (C.sub.3 -C.sub.7)-cycloalkylmethyl, (C.sub.3 -C.sub.7)cycloalkylamino and cyclohexenyl, it being possible for said radical to be substituted by a halogen, hydroxyl, (C.sub.1 -C.sub.4)-alkoxy, carboxyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, amino or mono- or di-(C.sub.1 -C.sub.4)-alkylamino; or(c) a group selected from a phenyl, phenoxy, phenylamino, N-(C.sub.1 -C.sub.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: March 7, 2000
    Assignee: Sanofi-Synthlabo
    Inventors: Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi
  • 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity
    Patent number: 5981754
    Abstract: The present invention relates to the compounds of formula (I) ##STR1## wherein Y is --CH-- or --N--; R.sub.1 is hydrogen, a halogen or a CF.sub.3, (C.sub.3 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group; R.sub.2 is hydrogen, a halogen, a hydroxyl or a CF.sub.3, (C.sub.3 -C.sub.4)alkyl or (C.sub.1 -C.sub.4)alkoxy group; R.sub.3 and R.sub.4 are each hydrogen or a (C.sub.1 -C.sub.3)alkyl; and X is (a) a (C.sub.3 -C.sub.6)alkyl, a (C.sub.3 -C.sub.6)alkoxy, a (C.sub.3 -C.sub.7)carboxyalkyl, a (C.sub.1 -C.sub.4)-alkoxycarbonyl(C.sub.3 -C.sub.6)alkyl, a (C.sub.3 -C.sub.7)carboxyalkoxy or a (C.sub.1 -C.sub.4)alkoxycarbonyl(C.sub.3 -C.sub.6)alkoxy; (b) a radical selected from a (C.sub.3 -C.sub.7)cycloalkyl, (C.sub.3 -C.sub.7)cycloalkoxy, (C.sub.3 -C.sub.7)cycloalkylmethyl, (C.sub.3 -C.sub.7)cycloalkylamino and cyclohexenyl, it being possible for said radical to be substituted by a halogen, hydroxyl, (C.sub.1 -C.sub.4)alkoxy, carboxyl, (C.sub.1 -C.sub.4)alkoxycarbonyl, amino or mono- or di-(C.sub.1 -C.sub.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: November 9, 1999
    Assignee: Sanofi
    Inventors: Domenico Badone, Marco Baroni, Rosanna Cardamone, Jacqueline Fournier, Umberto Guzzi, Alessandra Ielmini
  • Heteroarylpiperidines
    Patent number: 5723611
    Abstract: A compound of formula (VIII): ##STR1## in which Alk is a (C.sub.1 -C.sub.4)alkyl group, R.cndot. is hydrogen or a protecting group cleavable by hydrolysis and R is hydrogen, a protecting group cleavable by reduction or a heterocycle of structure (IX): ##STR2## in which Hal is a halogen atom and X, Y and Z are each --CH.dbd. or one of them is a nitrogen atom and the others are --CH.dbd., and its salts, R.cndot. being other than hydrogen if R is hydrogen or a group of structure (IX).
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 3, 1998
    Assignee: Sanofi
    Inventors: Marco Baroni, Tiziano Croci, Marco Landi, Umberto Guzzi, Dino Nisato
  • Enzymatic process for the preparation of optically active tetralin derivatives
    Patent number: 5719308
    Abstract: The present invention relates to an enzymatic process for the preparation of optically active tetrahydro-2-naphthoic acids from the corresponding racemic esters by reaction with a lipase.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: February 17, 1998
    Assignee: Sanofi
    Inventors: Roberto Cecchi, Laura Barzaghi, Umberto Guzzi