Patents by Inventor Umberto Pace

Umberto Pace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized external guide sequences
    Patent number: 6057153
    Abstract: Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: May 2, 2000
    Assignee: Yale University
    Inventors: Shaji T. George, Michael Ma, Martina Werner, Umberto Pace, Allan R. Goldberg
  • EGS-mediated inactivation of target RNA
    Patent number: 5683873
    Abstract: Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: November 4, 1997
    Assignee: Innovir Laboratories, Inc.
    Inventors: Shaji T. George, Michael Ma, Martina Werner, Umberto Pace, Allan R. Goldberg