Patents by Inventor Umesh Gangadharmath

Umesh Gangadharmath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9539349
    Abstract: A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: January 10, 2017
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Vani P. Mocharla, Fanrong Mu, Umesh Gangadharmath
  • Patent number: 9539350
    Abstract: A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: January 10, 2017
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Vani P. Mocharla, Fanrong Mu, Umesh Gangadharmath
  • Publication number: 20160243267
    Abstract: A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 25, 2016
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Vani P. Mocharla, Fanrong Mu, Umesh Gangadharmath
  • Publication number: 20160228585
    Abstract: A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 11, 2016
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Vani P. Mocharla, Fanrong Mu, Umesh Gangadharmath
  • Patent number: 9023316
    Abstract: A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: May 5, 2015
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Umesh Gangadharmath, Joseph Walsh, Hartmuth Kolb
  • Publication number: 20130005956
    Abstract: A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
    Type: Application
    Filed: April 8, 2011
    Publication date: January 3, 2013
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventors: Umesh Gangadharmath, Joseph Walsh, Hartmuth Kolb
  • Publication number: 20130005972
    Abstract: A method for generating a radiolabeled tracer. The method includes providing a phosphine molecule having at least one carbocyclic, aromatic, or pyrrolidinyl ring with an OH substitute. The OH of this phosphines molecule is then condensed with an acid to produce a phosphine ester. Staudinger ligation is then performed to generate the radiolabeled tracer by treating the phosphine ester with a radiolabeled azide having a PET radioisotope moiety.
    Type: Application
    Filed: March 29, 2011
    Publication date: January 3, 2013
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventors: Dhanalakshmi Kasi, Umesh Gangadharmath, Joseph Walsh, Hartmuth Kolb
  • Patent number: 7928210
    Abstract: Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: April 19, 2011
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Robert M Yeh, Kai Chen, Umesh Gangadharmath, Brian Duclos, Vani P. Mocharla, Farhad Karimi, Henry C. Padgett, Qianwa Liang, Tieming Zhao
  • Publication number: 20090016958
    Abstract: Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
    Type: Application
    Filed: March 3, 2008
    Publication date: January 15, 2009
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Robert M. Yeh, Kai Chen, Umesh Gangadharmath, Brian Duclos, Vani P. Mocharla, Farhad Karimi, Henry C. Padgett, Qianwa Liang, Tieming Zhao
  • Publication number: 20080213175
    Abstract: The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
    Type: Application
    Filed: September 17, 2007
    Publication date: September 4, 2008
    Inventors: Hartmuth C. Kolb, Kai Chen, Joseph C. Walsh, Umesh Gangadharmath, Dhanalakshmi Kasi, Bing Wang, Brian Duclos, Qianwa Liang, Henry Clifton Padgett, Farhad Karimi