Patents by Inventor Umesh R. Desai
Umesh R. Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220169673Abstract: A group of specific sulfated flavonoid agents carrying cholesterol modification display promising in vivo anti-cancer activity through selective inhibition of cancer stem cells, and not of adult or hematopoietic stem cells. The compounds exhibit high potency, excellent oral bioavailability and a physiologically relevant therapeutic window.Type: ApplicationFiled: March 6, 2020Publication date: June 2, 2022Inventors: Umesh R. DESAI, Balaji NAGARAJAN, Connor O'HARA, Daniel Kwame AFOSAH, Elsamani I. ABDELFADIEL, Jyothi SISTLA, Rahaman Navaz GANGJI, Ravikumar ONGOLU, Shravan MORLA, Viji SANKARANARAYANAN, Bhaumik B. PATEL, Chetna SHARON, Rio BOOTHELLO, Alberto VERA
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Patent number: 9850221Abstract: Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to selectively inhibit CSCs growth and self-renewal both in vitro and in vivo.Type: GrantFiled: November 7, 2014Date of Patent: December 26, 2017Assignee: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Umesh R. Desai, Rajesh Karuturi, Bhaumik B. Patel, Nirmita J. Patel
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Patent number: 9777123Abstract: Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.Type: GrantFiled: May 29, 2014Date of Patent: October 3, 2017Assignee: Virginia Commonwealth UniversityInventors: Umesh R. Desai, Jay Thakkar, Akul Mehta
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Patent number: 9758459Abstract: Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated gallolyl glucosides, ii) sulfated quinazolinones, and iii) sulfated inositol analogs. The compounds used as anticoagulant agents.Type: GrantFiled: November 12, 2013Date of Patent: September 12, 2017Assignee: Virginia Commonwealth UniversityInventors: Umesh R. Desai, Rajesh Karuturi, Akul Mehta, Rami A. Al-Horani
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Publication number: 20170058319Abstract: Constructs and monitoring systems to assess the level of molecules that bind to thrombin (e.g. thrombin regulators and inhibitors) are provided. The constructs are nanosensors comprising i) a thrombin molecule to which is bound a reporter ligand comprising a fluorescent label, ii) a fluorescence-quenching metal nanoparticle, and, optionally iii) a fluorescence-quenching dye molecule attached to one or both of the nanoparticle and the thrombin molecule. The binding of a thrombin regulator or inhibitor to the thrombin molecule displaces the reporter ligand, and the signal from the fluorescent label increases. The increase is proportional to the concentration of thrombin-binding molecule in the sample.Type: ApplicationFiled: March 25, 2015Publication date: March 2, 2017Inventors: Umesh R. Desai, Bruce D. Spiess, Donald F. Brophy, Erika J. Martin, Kuberan Balagurunathan
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Publication number: 20160311842Abstract: Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated gallolyl glucosides, ii) sulfated quinazolinones, and iii) sulfated inositol analogs. The compounds used as anticoagulant agents.Type: ApplicationFiled: November 12, 2013Publication date: October 27, 2016Inventors: Umesh R. DESAI, Rajesh KARUTURI, Akul MEHTA, Rami A. AL-HORANI
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Publication number: 20160280676Abstract: Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to selectively inhibit CSCs growth and self-renewal both in vitro and in vivo.Type: ApplicationFiled: November 7, 2014Publication date: September 29, 2016Inventors: Umesh R. Desai, Rajesh Karuturi, Bhaumik B. Patel, Nirmita J. Patel
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Publication number: 20160201112Abstract: High sensitivity nanosensors for detecting the inhibition of glycosaminoglycan (GAG)-cleaving enzymes are provided. Methods of using the nanosensors include detecting contaminants in commercial GAG preparations (e.g. heparin preparations) by measuring the activity levels of a GAG)-cleaving enzyme in the presence of a sample which may contain a contaminant that inhibits the GAG-cleaving enzyme.Type: ApplicationFiled: September 8, 2014Publication date: July 14, 2016Applicant: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Umesh R. Desai, Mausam Kalita, Kuberan Balagurunathan
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Publication number: 20160115280Abstract: Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.Type: ApplicationFiled: May 29, 2014Publication date: April 28, 2016Inventors: Umesh R. Desai, Jay Thakkar, Akul Mehta
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Patent number: 8993620Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. ?-O4 and ?-5 trimers and tetramers) are used as anticoagulants.Type: GrantFiled: November 22, 2013Date of Patent: March 31, 2015Assignee: Virginia Commonwealth UniversityInventors: Umesh R. Desai, Brian L. Henry, Aiye Liang, Jay Thakkar, John B. Mangrum, Ivo Torres Filho, Bruce D. Spiess, Masahiro Sakagami, Bhawana Saluja
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Publication number: 20140080904Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. ?-O4 and ?-5 trimers and tetramers) are used as anticoagulants.Type: ApplicationFiled: November 22, 2013Publication date: March 20, 2014Applicant: Virginia Commonwealth UniversityInventors: Umesh R. Desai, Brian L. Henry, Aiye Liang, Jay Thakkar, John B. Mangrum, Ivo Torres Filho, Bruce D. Spiess, Masahiro Sakagami, Bhawana Saluja
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Patent number: 8613909Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. ?-O4 and ?-5 trimers and tetramers) are used as anticoagulants.Type: GrantFiled: June 25, 2013Date of Patent: December 24, 2013Assignee: Virginia Commonwealth UniversityInventors: Umesh R. Desai, Brian L. Henry, Aiye Liang, Jay Thakkar, John B. Mangrum, Ivo Torres Filho, Bruce D. Spiess, Masahiro Sakagami, Bhawana Saluja
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Publication number: 20130289106Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. ?-O4 and ?-5 trimers and tetramers) are used as anticoagulants.Type: ApplicationFiled: June 25, 2013Publication date: October 31, 2013Inventors: Umesh R. Desai, Brian L. Henry, Aiye Liang, Jay Thakkar, John B. Mangrum, Ivo Torres Filho, Bruce D. Spiess, Masahiro Sakagami, Bhawana Saluja
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Patent number: 8491872Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. ?-O4 and ?-5 trimers and tetramers) are used as anticoagulants.Type: GrantFiled: August 4, 2009Date of Patent: July 23, 2013Assignee: Virginia Commonwealth UniversityInventors: Umesh R. Desai, Brian L. Henry, Aiye Liang, Jay Thakkar, John B. Mangrum, Ivo Torres Filho, Bruce D. Spiess, Masahiro Sakagami, Bhawana Saluja
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Patent number: 8262881Abstract: Methods to generate a distinctive fingerprint (pattern of migration) for a sample of complex, polydisperse heparins are provided. The methods involve adding resolving agents such as polyamines to a heparin sample and then analyzing the sample with a technique that separates macromolecules according to charge to mass ratio (e.g. capillary electrophoresis). The resulting electropherogram is unique to and characteristic of the heparin sample. The methods may be used, for example, to monitor the quality and consistency of various heparin preparations.Type: GrantFiled: February 27, 2009Date of Patent: September 11, 2012Assignee: Virginia Commonwealth UniversityInventors: Umesh R. Desai, J. Timothy King
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Publication number: 20120027691Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. ?-O4 and ?-5 trimers and tetramers) are used as anticoagulants.Type: ApplicationFiled: August 4, 2009Publication date: February 2, 2012Inventors: Umesh R. Desai, Brian L. Henry, Aiye Liang, Jay Thakkar, John B. Mangrum, Ivo Torres Filho, Bruce D. Spiess, Masahiro Sakagami, Bhawana Saluja
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Publication number: 20110060578Abstract: An agent-based modeling system (ABMS) is employed to quantitatively analyze individual components of each system of the coagulation-immune/inflammatory-fibrinolysis system at every point of simulation. ABMS is a dynamic modeling and simulation tool that allows the study of dynamic non-linear networked systems. ABMS represents a non-reductionist approach of studying the biologic process as a whole, while retaining information at the level of an individual component.Type: ApplicationFiled: March 3, 2009Publication date: March 10, 2011Applicant: Virginia Commonwealth UniversityInventors: Kevin Ward, Umesh R. Desai, Nathan Menke, Lemont B. Kier, C.K. Cheng
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Publication number: 20110048946Abstract: Methods to generate a distinctive fingerprint (pattern of migration) for a sample of complex, polydisperse heparins are provided. The methods involve adding resolving agents such as polyamines to a heparin sample and then analyzing the sample with a technique that separates macromolecules according to charge to mass ratio (e.g. capillary electrophoresis). The resulting electropherogram is unique to and characteristic of the heparin sample. The methods may be used, for example, to monitor the quality and consistency of various heparin preparations.Type: ApplicationFiled: February 27, 2009Publication date: March 3, 2011Inventors: Umesh R. Desai, J. Timothy King
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Patent number: 7402594Abstract: Sulfated bis-cyclic compounds that are potent anticoagulants and methods for their manufacture are provided. The sulfated compounds are bis-cyclic moieties comprised of an isoquinoline ring joined to a phenyl ring with the general chemical structure formula (I) where R2 is hydrogen or a sulfate moiety, R3 is either hydrogen or carboxylate moiety; R4 is a hydrogen or oxygen; and R5 is a hydrogen if R4 is a hydrogen, and is absent if R4 is oxygen. Counterions such as sodium may also be coordinated to the sulfate and carboxylate moieties.Type: GrantFiled: May 19, 2004Date of Patent: July 22, 2008Assignee: Virginia Commonwealth UniversityInventors: Umesh R. Desai, Gunnar Gunnarsson