Patents by Inventor Umit Yuksel
Umit Yuksel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8071124Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.Type: GrantFiled: January 26, 2005Date of Patent: December 6, 2011Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Ana T. Bird, Kirby S. Black
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Patent number: 8057818Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.Type: GrantFiled: January 26, 2005Date of Patent: November 15, 2011Assignee: CryoLife, Inc.Inventors: K. Umit Yüksel, Ana T. Bird, Kirby S. Black
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Patent number: 7896920Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.Type: GrantFiled: October 31, 2007Date of Patent: March 1, 2011Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
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Patent number: 7621954Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.Type: GrantFiled: December 8, 2006Date of Patent: November 24, 2009Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
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Patent number: 7621959Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms. the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.Type: GrantFiled: December 10, 2004Date of Patent: November 24, 2009Assignee: CryoLife, Inc.Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
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Patent number: 7226615Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.Type: GrantFiled: November 7, 2001Date of Patent: June 5, 2007Assignee: CryoLife, Inc.Inventors: K. Ümit Yüksel, Ana T. Bird, Kirby S. Black
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Patent number: 6921412Abstract: Self-supporting, shaped, three-dimensional cross-linked proteinaceous biopolymeric materials that may be implanted in vivo, and methods of making such materials are disclosed. The biopolymeric materials most preferably include reinforcing media, such as biocompatible fibrous or particulate materials. In use, the preformed, shaped biopolymeric materials may be applied to tissue in need of repair and then sealed around its edges with a liquid bioadhesive. In such a manner, repaired tissue which is capable of withstanding physiological pressures may be provided.Type: GrantFiled: May 12, 2000Date of Patent: July 26, 2005Assignee: Cryolife, Inc.Inventors: Kirby S. Black, K. Umit Yuksel, Aaron J. Trygstad
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Patent number: 6849262Abstract: This invention relates to methods of coating the lumenal surface of a blood vessel, or other tissue cavity, and to compositions suitable for use in same.Type: GrantFiled: February 7, 2002Date of Patent: February 1, 2005Assignee: Cryolife, Inc.Inventors: Jeremy Ollerenshaw, Umit Yuksel, Kirby S. Black
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Patent number: 6685726Abstract: A method of anastomosing two hollow bodily organs using a bioadhesive. The method involves apposing apertures in the organs to be joined and applying the bloadhesive, thereby joining the apertures in the organs and allowing movement of fluid or semi-solid material from one of the two organs to the second organ. A device for anastomosing two hollow organs. The device has two inflatable balloons, one of which is placed into the lumen of each of the two organs to be joined. Inflation of the balloons holds the apertures together while the bioadhesives is applied. The device allows for endoscopic anastomosis of blood vessels.Type: GrantFiled: September 25, 1998Date of Patent: February 3, 2004Assignee: Cryolife, Inc.Inventors: Kirby S. Black, Steve Gundry, Ümit Yüksel
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Publication number: 20020183244Abstract: This invention relates to methods of coating the lumenal surface of a blood vessel, or other tissue cavity, and to compositions suitable for use in same.Type: ApplicationFiled: February 7, 2002Publication date: December 5, 2002Applicant: CRYOLIFE, INC.Inventors: Jeremy Ollerenshaw, Umit Yuksel, Kirby S. Black
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Publication number: 20020138098Abstract: A method of anastomosing two hollow bodily organs using a bioadhesive. The method involves apposing apertures in the organs to be joined and applying the bioadhesive, thereby joining the apertures in the organs and allowing movement of fluid or semi-solid material from one of the two organs to the second organ. The invention also relates to a device for anastomosing two hollow organs. The device has two inflatable balloons, one of which is placed into the lumen each of the two organs to be joined. Inflation of the balloons holds the apertures together while the bioadhesive is applied. The device allows anastomosis of blood vessels through endoscopic means.Type: ApplicationFiled: September 25, 1998Publication date: September 26, 2002Inventors: KIRBY S. BLACK, STEVE GUNDRY, UMIT YUKSEL
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Publication number: 20020059001Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.Type: ApplicationFiled: November 7, 2001Publication date: May 16, 2002Inventors: K. Umit Yuksel, Ana T. Bird, Kirby S. Black
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Publication number: 20020049498Abstract: Bioprosthetic devices include an exterior biological tissue member which at least partly defines a cavity, and a proteinaceous biopolymer which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device is a bioprosthetic vertebral disc having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer. Preferably, the proteinaceous biopolymer is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.Type: ApplicationFiled: October 24, 2001Publication date: April 25, 2002Inventors: K. Umit Yuksel, Steven P. Walsh, Kirby S. Black
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Patent number: 6372229Abstract: This invention relates to methods of coating the lumenal surface of a blood vessel, or other tissue cavity, and to compositions suitable for use in same.Type: GrantFiled: September 15, 2000Date of Patent: April 16, 2002Assignee: Cryolife, Inc.Inventors: Jeremy Ollerenshaw, Umit Yuksel, Kirby S. Black
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Patent number: 6245083Abstract: A method of anastomosing two hollow bodily organs using a bioadhesive. The method involves apposing apertures in the organs to be joined and applying the bioadhesive, thereby joining the apertures in the organs and allowing movement of fluid or semi-solid material from one of the two organs to the second organ. The invention also relates to a device for anastomosing two hollow organs. The device has two inflatable balloons, one of which is placed into the lumen each of the two organs to be joined. Inflation of the balloons holds the apertures together while the bioadhesive is applied. The device allows anastomosis of blood vessels through endoscopic means.Type: GrantFiled: November 19, 1999Date of Patent: June 12, 2001Assignee: Cryolife, Inc.Inventors: Kirby S. Black, Steve Gundry, Ümit Yüksel