Patents by Inventor Umrao MONANI

Umrao MONANI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING MOTOR NEURON DISEASES
    Publication number: 20240016889
    Abstract: The present disclosure provides compositions and methods of treating motor neuron diseases, including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). A modulator of a heat shock protein, such as an Hsp70 family member protein, may be used in the present method. Alternatively, a mutant heat shock protein may be used.
    Type: Application
    Filed: September 22, 2023
    Publication date: January 18, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Umrao MONANI, Jeong KI-KIM
  • Compositions and methods for treating motor neuron diseases
    Patent number: 11801284
    Abstract: The present disclosure provides compositions and methods of treating motor neuron diseases, including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). A modulator of a heat shock protein, such as an Hsp70 family member protein, may be used in the present method. Alternatively, a mutant heat shock protein may be used.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: October 31, 2023
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Umrao Monani, Jeong Ki-Kim
  • SLC2A1 LNCRNA AS A BIOLOGIC AND RELATED TREATMENTS AND METHODS
    Publication number: 20210222167
    Abstract: The present invention relates to a novel antisense transcript to the human SLC2A1 (Glut1) gene, variants and fragments thereof. This antisense transcript can be used to modulate Glut1 expression and serve to restore Glut1, and as a therapeutic for treating or preventing Glut 1 deficiency syndrome, or other Glut1 related conditions including certain cancers, diabetes, Alzheimer's disease, and retinitis pigmentosa.
    Type: Application
    Filed: October 12, 2018
    Publication date: July 22, 2021
    Inventors: Umrao Monani, Maoxue Tang
  • RECOMBINANT GLUT1 ADENO-ASSOCIATED VIRAL VECTOR CONSTRUCTS AND RELATED METHODS FOR RESTORING GLUT1 EXPRESSION
    Publication number: 20210069292
    Abstract: The present invention relates to recombinant Glut1 adeno-associated viral vector (AAV) constructs and related methods for restoring Glut1 expression in Glut1 deficient mammals.
    Type: Application
    Filed: November 19, 2020
    Publication date: March 11, 2021
    Inventors: Darryl DE VIVO, Umrao MONANI, Guangping GAO, Kristin ENGELSTAD
  • COMPOSITIONS AND METHODS FOR TREATING MOTOR NEURON DISEASES
    Publication number: 20200360472
    Abstract: The present disclosure provides compositions and methods of treating motor neuron diseases, including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). A modulator of a heat shock protein, such as an Hsp70 family member protein, may be used in the present method. Alternatively, a mutant heat shock protein may be used.
    Type: Application
    Filed: December 13, 2018
    Publication date: November 19, 2020
    Inventors: Umrao MONANI, Jeong KI-KIM
  • RECOMBINANT GLUT1 ADENO-ASSOCIATED VIRAL VECTOR CONSTRUCTS AND RELATED METHODS FOR RESTORING GLUT1 EXPRESSION
    Publication number: 20180042991
    Abstract: The present invention relates to recombinant Glut1 adeno-associated viral vector (rAAV) constructs and related methods for restoring Glut1 expression in Glut1 deficient mammals. In certain embodiments, the rAAV further comprises a chicken ?-actin promoter wherein the rAAV is capable of crossing the blood-brain barrier (BBB). In certain embodiments, the present invention relates to a composition comprising any of the recombinant AAV's described herein. In certain embodiments, the present invention relates to a kit comprising a container housing comprising the composition described herein. In certain embodiments, the present invention relates to methods of restoring Glut1 transport in the BBB of a subject, comprising administering to the subject an effective amount of any of the recombinant AAV vectors described herein. In certain embodiments, the present invention relates to a method of treating Glut1 deficiency syndrome in a subject in need thereof.
    Type: Application
    Filed: March 10, 2016
    Publication date: February 15, 2018
    Inventors: Darryl DE VIVO, Umrao MONANI, Guangping GAO, Kristin ENGELSTAD