Abstract: An electronic home plate providing assistance to an umpire in determination whether a pitch results in a “strike” or a “ball”. The electronic home plate is implemented with eye-safe LEDs producing light beams extending vertically. If a ball intersects the light beams, the light reflected from the ball is scattered and incident on photodetectors embedded in the home plate. A microcomputer embedded in the electronic home plate calculates the height of the ball crossing the light beams, and if the height falls between the top and bottom boundaries of a strike zone adjusted to the height of the batter, an indication system is activated to produce a “strike” signal. The microcomputer in the electronic home plate is further configured to calculate speed of the ball passing over the home plate, and the lateral position of the ball.

Abstract: Provided are methods of treatment in subjects having progeroid diseases and related conditions which rely upon LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Abstract: The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient resolution to view the location of intracellular components labeled with luminescent molecules as well as interaction with other biomolecules and responses to localized environmental variables in living cells and tissues during the application of a microwave field.

Abstract: Minimally invasive neurosurgical intracranial robot system is introduced to the operative site by a neurosurgeon through a narrow surgical corridor. The robot is passed through a cannula and is attached to the cannula by a latching mechanism. The robot has several links interconnected via revolute joints which are tendon-driven by tendons routed through channels formed in the walls of the links. The robot is teleoperatively guided by the neurosurgeon based on real-time images of the intracranial operative site and tracking information of the robot position. The robot body is equipped with a tracking system, tissue liquefacting end-effector, at as well as irrigation and suction tubes. Actuators for the tendon-driven mechanism are positioned at a distance from the imaging system to minimize distortion to the images. The tendon-actuated navigation of the robot permits an independent control of the revolute joints in the robot body.

Abstract: TIR-domain decoy peptides and TIR domain peptides are disclosed, as well as methods of using the peptides in the regulation of toll-like receptor (TLR) activation and signaling.

Abstract: The present invention provides for monodispersed dendrimers having a core, branches and periphery ends, wherein the number of branches increases exponentially from the core to the periphery end and the length of the branches increases exponentially from the periphery end to the core, thereby providing for attachment of chemical species at the periphery ends without exhibiting steric hindrance.

Abstract: Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions.

Abstract: The subject authentication scheme encompasses a large family of authentication systems which may be built over existing transmission systems. By superimposing a carefully designed secret modulation on the waveforms, authentication is added to the signal without requiring additional bandwidth. The authentication information (tag signal) is sent concurrently with data (message signal). The authentication is designed to be stealthy to the uninformed user, robust to interference, and secure for identity verification. The tradeoffs between these three goals are identified and analyzed. The use of the authentication for channel estimation is also considered, and improved bit errors are demonstrated for time-varying channels. With a long enough authentication code word an authentication system is achieved with very slight data degradation. Additionally, by treating the authentication tag as a sequence of pilot symbols, the data recovery may be improved by the aware receiver.

Abstract: An initial (near-field) spray generated by a sprinkler under study is fully characterized using a laser-supported Shadowgraphy/PTV system. Near-field spray characteristics are established from local measurements, which are mapped in a spherical coordinate system consistent with the kinematics of the spray. A novel data compression scheme is introduced to generate analytical functions describing the sprinkler spray based on the measurements. These analytical functions are useful for initiating the sprinkler spray in computational fluid dynamics (CFD) based spray dispersion and fire suppression modeling. The near-field spray measurements and associated data compression approach are validated by comparing volume density measurements 1 meter below the sprinkler with volume density predictions generated from spray dispersion calculations initiated with the analytical spray functions.