Abstract: A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.

Abstract: An electronic home plate providing assistance to an umpire in determination whether a pitch results in a “strike” or a “ball”. The electronic home plate is implemented with eye-safe LEDs producing light beams extending vertically. If a ball intersects the light beams, the light reflected from the ball is scattered and incident on photodetectors embedded in the home plate. A microcomputer embedded in the electronic home plate calculates the height of the ball crossing the light beams, and if the height falls between the top and bottom boundaries of a strike zone adjusted to the height of the batter, an indication system is activated to produce a “strike” signal. The microcomputer in the electronic home plate is further configured to calculate speed of the ball passing over the home plate, and the lateral position of the ball.

Abstract: Provided are methods of treatment in subjects having progeroid diseases and related conditions which rely upon LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Abstract: A method and devices are described, in which a transformable fiber at a first crystal structure is shaped from its pre-determined configuration into a new shaped configuration. The new shaped configuration of the transformable fiber is inserted into a cavity of a heat and fire protective item. The new shaped configuration of the transformable fiber is heated to above its transformation temperature to a second crystal structure. The heating transforms the new shaped configuration to its pre-determined configuration, wherein the pre-determined configuration forms an air pocket within the heat and fire protective item. The transformable fiber is cooled below its transformation temperature to revert the transformable fiber back to the new shaped configuration at the first crystal structure.

Abstract: Minimally invasive neurosurgical intracranial robot system is introduced to the operative site by a neurosurgeon through a narrow surgical corridor. The robot is passed through a cannula and is attached to the cannula by a latching mechanism. The robot has several links interconnected via revolute joints which are tendon-driven by tendons routed through channels formed in the walls of the links. The robot is teleoperatively guided by the neurosurgeon based on real-time images of the intracranial operative site and tracking information of the robot position. The robot body is equipped with a tracking system, tissue liquefacting end-effector, at as well as irrigation and suction tubes. Actuators for the tendon-driven mechanism are positioned at a distance from the imaging system to minimize distortion to the images. The tendon-actuated navigation of the robot permits an independent control of the revolute joints in the robot body.

Abstract: The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient resolution to view the location of intracellular components labeled with luminescent molecules as well as interaction with other biomolecules and responses to localized environmental variables in living cells and tissues during the application of a microwave field.

Abstract: TIR-domain decoy peptides and TIR domain peptides are disclosed, as well as methods of using the peptides in the regulation of toll-like receptor (TLR) activation and signaling.

Abstract: The present invention provides for monodispersed dendrimers having a core, branches and periphery ends, wherein the number of branches increases exponentially from the core to the periphery end and the length of the branches increases exponentially from the periphery end to the core, thereby providing for attachment of chemical species at the periphery ends without exhibiting steric hindrance.

Abstract: Described herein are methods and systems, including computer program products, for optimizing and controlling the energy consumption of a building. A first computing device generates a set of thermal response coefficients for the building based on energy characteristics of the building and weather data associated with the location of the building. The first computing device predicts an energy response of the building based on the set of thermal response coefficients and forecasted weather associated with the location of the building. The first computing device selects minimal energy requirements of the building based on an energy consumption cost associated with the building. The first computing device determines one or more temperature set points for the building based on the energy response and the minimal energy requirements. The first computing device transmits the one or more temperature set points to a thermostat of the building.

Abstract: Peptide antagonists of zonulin are disclosed, as well as methods for the use of the same. The peptide antagonists bind to the zonula occludens receptor, yet do not physiologically modulate the opening of mammalian tight junctions.

Abstract: The subject authentication scheme encompasses a large family of authentication systems which may be built over existing transmission systems. By superimposing a carefully designed secret modulation on the waveforms, authentication is added to the signal without requiring additional bandwidth. The authentication information (tag signal) is sent concurrently with data (message signal). The authentication is designed to be stealthy to the uninformed user, robust to interference, and secure for identity verification. The tradeoffs between these three goals are identified and analyzed. The use of the authentication for channel estimation is also considered, and improved bit errors are demonstrated for time-varying channels. With a long enough authentication code word an authentication system is achieved with very slight data degradation. Additionally, by treating the authentication tag as a sequence of pilot symbols, the data recovery may be improved by the aware receiver.

Abstract: Various communication systems may benefit from physical layer watermarking. For example, active sensing for dynamic spectrum access may be performed using physical layer watermarking, such as watermarking based on channel effects and/or receiver distortion. A method may include, for example, obtaining an original signal to be transmitted to at least one receiver. The method may also include watermarking the original signal with at least one of authentication data or ancillary data to provide an enhanced signal. The watermarking can include a physical layer watermark. The physical layer watermark can be configured to emulate at least one a channel effect or a receiver distortion. The method can further include transmitting the enhanced signal to the at least one receiver.

Abstract: The present invention provides for recombinant Endo-D and selected mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor by transglycosylation. Such recombinant Endo-D and selected mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain.

Abstract: The present invention is drawn to multivalent Salmonella enterica serovar conjugate vaccines comprising conjugates of S. Typhimurium, S. Enteritidis, S. Choleraesuis, S. Typhi, S. Paratyphi A and optionally S. Paratyphi B, wherein the conjugates comprise a hapten antigen and a carrier antigen, wherein at least one of the hapten antigens or carrier antigens is characteristic of the Salmonella enterica serovar. The present invention also provides Salmonella enterica serovar reagent strains to produce the multivalent conjugate vaccines and attenuated Salmonella enterica serovars for use as vaccines.

Abstract: Disclosed are compositions, antibodies, and methods for binding intracellular antigens.

Abstract: An initial (near-field) spray generated by a sprinkler under study is fully characterized using a laser-supported Shadowgraphy/PTV system. Near-field spray characteristics are established from local measurements, which are mapped in a spherical coordinate system consistent with the kinematics of the spray. A novel data compression scheme is introduced to generate analytical functions describing the sprinkler spray based on the measurements. These analytical functions are useful for initiating the sprinkler spray in computational fluid dynamics (CFD) based spray dispersion and fire suppression modeling. The near-field spray measurements and associated data compression approach are validated by comparing volume density measurements 1 meter below the sprinkler with volume density predictions generated from spray dispersion calculations initiated with the analytical spray functions.

Abstract: Methods for controlling and regulating engulfment, uptake and/or transcellular transport at a stage following initial engagement of an agent to the endothelium are provided, based on the identification of CAM-mediated endocytosis and the sphingomyelin/ceramide pathway as active steps in transcellular TEM. Administration of regulators relating to the identified pathways, such as NHE1, sphingomyelinases, acid sphingomyelinase and ceramide, permit control and regulation of uptake and transcellular transport. Control and regulation of uptake and/or transcellular transport is applicable in strategies to modulate inflammation, provide controlled and/or targeted delivery of agents, control pathogenic invasion, recover action of an inhibited CAM-mediated uptake or transendothelial pathway, or provide uptake or transendothelial transport by targeting cell surface markers other than ICAM-1.