Patents by Inventor Unmesh G. Shah

Unmesh G. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic piperidine and piperazine derivatives as GPCR modulators for the treatment of obesity, diabetes and other metabolic disorders
    Patent number: 8580807
    Abstract: The present invention relates to Bicyclic Piperidine and piperazine Derivatives, compositions comprising a Bicyclic Piperidine and piperazine Derivative, and methods of using the Bicyclic Piperidine and piperazine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: November 12, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Craig D. Boyle, Claire M. Lankin, Unmesh G. Shah, William J. Greenlee, Samuel Chackalamannil
  • Pyrimidinone derivatives and methods of use thereof
    Patent number: 8318751
    Abstract: The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disease, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: November 27, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Craig D. Boyle, Samuel Chackalamannil, Claire M. Lankin, Unmesh G. Shah, Bernard R. Neustadt, Hong Liu, Andrew W. Stamford
  • BICYCLIC PIPERIDINE AND PIPERAZINE DERIVATIVES AS GPCR MODULATORS FOR THE TREATMENT OF OBESITY, DIABETES AND OTHER METABOLIC DISORDERS
    Publication number: 20120021976
    Abstract: The present invention relates to Bicyclic Piperidine and piperazine Derivatives, compositions comprising a Bicyclic Piperidine and piperazine Derivative, and methods of using the Bicyclic Piperidine and piperazine Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient.
    Type: Application
    Filed: April 1, 2010
    Publication date: January 26, 2012
    Inventors: Craig D. Boyle, Claire M. Lankin, Unmesh G. Shah, William J. Greenlee, Samuel Chackalamannil
  • PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20100190687
    Abstract: The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 (“GPR119”) in a patient.
    Type: Application
    Filed: April 17, 2008
    Publication date: July 29, 2010
    Inventors: Craig D. Boyle, Santhosh Francis Neelamkavil, Samuel Chackalamannil, Bernard R. Neustadt, Jinsong Hao, Unmesh G. Shah, Joel M. Harris, Hong Liu, Andrew W. Stamford
  • PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20100113487
    Abstract: The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disease, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
    Type: Application
    Filed: April 17, 2008
    Publication date: May 6, 2010
    Inventors: Craig D Boyle, Samuel Chackalamannil, Claire M. Lankin, Unmesh G. Shah, Bernard R. Neustadt, Hong Liu, Andrew W. Stamford
  • Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A receptor antagonists
    Patent number: 7709492
    Abstract: Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: May 4, 2010
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Jinsong Hao, Hong Liu, Craig D. Boyle, Samuel Chackalamannil, Unmesh G. Shah, Andrew Stamford, Joel M. Harris
  • 2-alkynyl- and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine Areceptor antagonists
    Patent number: 7368449
    Abstract: Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; R6 is H, alkyl, hydroxyalkyl or —CH2F; R7, R8 and R9 are H, alkyl, alkoxy, alkylthio, alkoxyalkyl, halo or —CF3; and Z is optionally substituted aryl, heteroaryl or heteroaryl-alkyl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: May 6, 2008
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Jinsong Hao, Hong Liu, Craig D. Boyle, Samuel Chackalamannil, Unmesh G. Shah, Andrew Stamford
  • Adenosine A2a receptor antagonists
    Patent number: 6916811
    Abstract: Disclosed herein are compounds having the structural formula A including pharmaceutically acceptable salts or solvates of said compound, wherein X, Y, Q and R are as defined in the specification; pharmaceutical compositions thereof; methods of treating central nervous system diseases by administering the compound of the present invention to a patient in need of such treatment, and processes for preparing the compound of this invention.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: July 12, 2005
    Assignee: Schering Corporation
    Inventors: Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Unmesh G. Shah, Yan Xia
  • 2-Alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
    Patent number: 6897217
    Abstract: Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; R6 is H, alkyl, hydroxyalkyl or —CH2F; R7, R8 and R9 are H, alkyl, alkoxy, alkylthio, alkoxyalkyl, halo or —CF3; and Z is optionally substituted aryl, heteroaryl or heteroaryl-alkyl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: May 24, 2005
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Jinsong Hao, Hong Liu, Craig D. Boyle, Samuel Chackalamannil, Unmesh G. Shah, Andrew Stamford
  • 2-Alkynyl-and 2-alkenyl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists
    Publication number: 20040220194
    Abstract: Compounds having the structural formula I 1
    Type: Application
    Filed: April 21, 2004
    Publication date: November 4, 2004
    Applicant: Schering Corporation
    Inventors: Bernard R. Neustadt, Jinsong Hao, Hong Liu, Craig D. Boyle, Samuel Chackalamannil, Unmesh G. Shah, Andrew Stamford
  • Adenosine A2a receptor antagonists
    Publication number: 20030212059
    Abstract: Disclosed herein are compounds having the structural formula A 1
    Type: Application
    Filed: November 26, 2002
    Publication date: November 13, 2003
    Applicant: Schering Corporation
    Inventors: Craig D. Boyle, Samuel Chackalamannil, William J. Greenlee, Unmesh G. Shah, Yan Xia