Patents by Inventor Upendra Marathi

Upendra Marathi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same
    Patent number: 10786444
    Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: September 29, 2020
    Assignee: PLx Opco Inc.
    Inventors: Upendra Marathi, Susann Childress, Shaun Gammill, Robert W. Strozier
  • pH DEPENDENT CARRIERS FOR TARGETED RELEASE OF PHARMACEUTICALS ALONG THE GASTROINTESTINAL TRACT, COMPOSITIONS THEREFROM, AND MAKING AND USING SAME
    Publication number: 20200222309
    Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
    Type: Application
    Filed: March 27, 2020
    Publication date: July 16, 2020
    Applicant: PLx Opco Inc.
    Inventors: Upendra Marathi, Susann Childress, Shaun Gammill, Robert W. Strozier
  • Compositions and methods for array-based genomic nucleic acid analysis of biological molecules
    Publication number: 20060275787
    Abstract: The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2 , wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or “biochips,” comprising these modified biological molecules. Also provided are methods for making and using these compositions.
    Type: Application
    Filed: December 27, 2005
    Publication date: December 7, 2006
    Inventors: Allan Bradley, Wei-Wen Cai, Upendra Marathi
  • Articles of manufacture and methods for array based analysis of biological molecules
    Patent number: 6979728
    Abstract: The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2, wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or “biochips,” comprising these modified biological molecules. Also provided are methods for making and using these compositions.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: December 27, 2005
    Assignees: Baylor College of Medicine, Spectral Genomics, Inc.
    Inventors: Allan Bradley, Wei-Wen Cai, Upendra Marathi
  • Compositions and methods for array-based genomic nucleic acid analysis of biological molecules
    Publication number: 20020006623
    Abstract: The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2, wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to the alkoxysilane group. The invention also provides arrays, or “biochips,” comprising these modified biological molecules. Also provided are methods for making and using these compositions.
    Type: Application
    Filed: May 10, 2001
    Publication date: January 17, 2002
    Inventors: Allan Bradley, Wei-Wen Cai, Upendra Marathi