Patents by Inventor Urban Schmitt

Urban Schmitt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10197559
    Abstract: The invention concerns a fusion polypeptide including several molecules of folding helper polypeptides, including one multimerization domain, in particular Skp, and at least one molecule of SlyD or SlpA, wherein no further target polypeptide sequences are fused to the fusion polypeptide. The invention further concerns an immunoassay and the use of the fusion polypeptide in an immunoassay for reduction of interferences or minimizing false positive results or for stabilizing proteinaceous assay reagents. Further the invention concerns a reagent kit for use in an immunoassay comprising the fusion polypeptide.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: February 5, 2019
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Hartmut Duefel, Alexander Riedel, Peter Schaarschmidt, Urban Schmitt, Christian Scholz
  • Publication number: 20170261498
    Abstract: The invention concerns a fusion polypeptide comprising several molecules of folding helper polypeptides, comprising one multimerization domain, in particular Skp, and at least one molecule of SlyD or SlpA, wherein no further target polypeptide sequences are fused to said fusion polypeptide. The invention further concerns an immunoassay and the use of said fusion polypeptide in an immunoassay for reduction of interferences or minimizing false positive results or for stabilizing proteinaceous assay reagents. Further the invention concerns a reagent kit for use in an immunoassay comprising said fusion polypeptide.
    Type: Application
    Filed: March 6, 2015
    Publication date: September 14, 2017
    Inventors: Hartmut Duefel, Alexander Riedel, Peter Schaarschmidt, Urban Schmitt, Christian Scholz
  • Patent number: 9714949
    Abstract: The invention relates to a method for detecting antibodies against the TpN17 antigen of Treponema pallidum in an isolated sample wherein a peptide sequence of Vibrio cholerae lipoprotein 15 (VcLp15) or a partial sequence thereof is used as a reagent for reduction of interference, i.e. for minimizing false positive results. In addition the invention relates to fusion polypeptides comprising a VcLp15 peptide sequence and a chaperone, to their use as an additive in an immunoassay for said reduction of interferences and for minimizing false positive results and to a reagent kit for detecting antibodies against Treponema pallidum antigens in an isolated sample comprising a TpN17 antigen and said VcLp15-chaperone fusion polypeptide.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: July 25, 2017
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Elke Faatz, Peter Schaarschmidt, Urban Schmitt, Christian Scholz
  • Patent number: 9316642
    Abstract: The invention concerns soluble variants of Treponema pallidum antigen 47 (TpN47 antigen) comprising at least domain B, or at least domains A and B, optionally domain D of the complete TpN47 protein molecule with the proviso that all antigens lack domain C (amino acid residues 224 to 351) of TpN47. The Tpn47 antigens can be fused to a chaperone. Moreover, the invention covers DNA encoding the antigens, a method of producing these antigens as well as the use of these antigens in an immunodiagnostic assay for the detection of antibodies against Treponema pallidum in an isolated sample.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: April 19, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Elke Faatz, Peter Schaarschmidt, Urban Schmitt, Christian Scholz
  • Patent number: 9261510
    Abstract: The present invention relates to fusion proteins suitable as test antigens in the detection of infections with pathogens, particularly of primary infections with pathogens. Further, the invention relates to methods for detecting and differentially determining antibodies, particularly IgM antibodies resulting from an infection with a pathogenic organism. Furthermore, test reagents for carrying out these methods are provided.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: February 16, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christian Schotz, Elke Faatz, Peter Schaarschmidt, Urban Schmitt
  • Publication number: 20150132859
    Abstract: The invention relates to a method for detecting antibodies against the TpN17 antigen of Treponema pallidum in an isolated sample wherein a peptide sequence of Vibrio cholerae lipoprotein 15 (VcLp15) or a partial sequence thereof is used as a reagent for reduction of interference, i.e. for minimizing false positive results. In addition the invention relates to fusion polypeptides comprising a VcLp15 peptide sequence and a chaperone, to their use as an additive in an immunoassay for said reduction of interferences and for minimizing false positive results and to a reagent kit for detecting antibodies against Treponema pallidum antigens in an isolated sample comprising a TpN17 antigen and said VcLp15-chaperone fusion polypeptide.
    Type: Application
    Filed: July 18, 2014
    Publication date: May 14, 2015
    Inventors: Elke Faatz, Peter Schaarschmidt, Urban Schmitt, Christian Scholz
  • Publication number: 20150079604
    Abstract: The invention concerns soluble variants of Treponema pallidum antigen 47 (TpN47 antigen) comprising at least domain B, or at least domains A and B, optionally domain D of the complete TpN47 protein molecule with the proviso that all antigens lack domain C (amino acid residues 224 to 351) of TpN47. The Tpn47 antigens can be fused to a chaperone. Moreover, the invention covers DNA encoding the antigens, a method of producing these antigens as well as the use of these antigens in an immunodiagnostic assay for the detection of antibodies against Treponema pallidum in an isolated sample.
    Type: Application
    Filed: July 18, 2014
    Publication date: March 19, 2015
    Inventors: Elke Faatz, Peter Schaarschmidt, Urban Schmitt, Christian Scholz
  • Patent number: 8790659
    Abstract: Disclosed are a recombinant DNA molecule encoding a fusion protein comprising a SlpA chaperone and a target polypeptide wherein human FK506 binding proteins (FKBPs) are excluded as target polypeptides, a corresponding expression vector encoding said fusion protein as well as host cells transformed with said expression vector. Also disclosed are a method for producing the fusion protein, a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide. A further aspect of the invention is the use of the recombinantly produced fusion protein, and a reagent kit containing a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: July 29, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christian Scholz, Elke Faatz, Urban Schmitt, Peter Schaarschmidt
  • Patent number: 8490417
    Abstract: A method of operating an ice maker including accepting a desired ice layer thickness setting, opening a water supply inlet valve to admit water from a water supply inlet, cooling an ice forming surface below freezing, directing the admitted water into a water collecting device, sensing an admitted volume of water, closing the water supply inlet valve based upon the sensed volume of admitted water and the set desired ice layer thickness, pumping water from the water collecting device to the ice forming surface via a recirculating pump, directing unfrozen water from the ice forming surface back to the water collecting device, determining a level of water in the water collecting device with a level sensor, initiating an ice harvesting routine based on input from the level sensor, operating a drain flow control device to selectively discharge water from the water collecting device to a drain outlet.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: July 23, 2013
    Assignee: Whirlpool Corporation
    Inventors: Melissa Marie Bippus, John P. Tinney, Ravindra S. Kavchale, Matthew E. Herr, Beth Michelle Gehlhausen, Gregory Urban Schmitt, Brian Joseph Beuligmann, Roger Urban Merkel
  • Patent number: 8426167
    Abstract: The present invention relates to the cloning and expression of foreign protein or polypeptides in bacteria, such as Escherichia coli. In particular, this invention relates to expression tools comprising a FKBP-type peptidyl prolyl isomerase selected from the group consisting of FkpA, SlyD, and trigger factor; methods of recombinant protein expression, the recombinant polypeptides thus obtained, as well as to the use of such polypeptides.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: April 23, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christian Scholz, Herbert Andres, Elke Faatz, Alfred Engel, Urban Schmitt, Ariuna Bazarsuren, Peter Schaarschmidt
  • Publication number: 20120308994
    Abstract: Disclosed are a recombinant DNA molecule encoding a fusion protein comprising a SlpA chaperone and a target polypeptide wherein human FK506 binding proteins (FKBPs) are excluded as target polypeptides, a corresponding expression vector encoding said fusion protein as well as host cells transformed with said expression vector. Also disclosed are a method for producing the fusion protein, a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide. A further aspect of the invention is the use of the recombinantly produced fusion protein, and a reagent kit containing a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide.
    Type: Application
    Filed: August 8, 2012
    Publication date: December 6, 2012
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Christian Scholz, Elke Faatz, Urban Schmitt, Peter Schaarschmidt
  • Patent number: 8263086
    Abstract: Disclosed are a recombinant DNA molecule encoding a fusion protein comprising a SlpA chaperone and a target polypeptide wherein human FK506 binding proteins (FKBPs) are excluded as target polypeptides, a corresponding expression vector encoding said fusion protein as well as host cells transformed with said expression vector. Also disclosed are a method for producing the fusion protein, a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide. A further aspect of the invention is the use of the recombinantly produced fusion protein, and a reagent kit containing a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: September 11, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christian Scholz, Elke Faatz, Urban Schmitt, Peter Schaarschmidt
  • Patent number: 8247206
    Abstract: The invention discloses the cloning, expression and uses of a chimeric fusion protein with superior chaperone and folding activities compared to the wild type chaperones. This invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule containing nucleotide sequences coding for a polypeptide binding segment of a non-human chaperone protein and nucleotide sequences coding for an FK506 binding protein (FKBP) or an FK506-binding-protein-like domain (FKBP-like domain).
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: August 21, 2012
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christian Scholz, Elke Faatz, Peter Schaarschmidt, Urban Schmitt
  • Publication number: 20110189754
    Abstract: The invention discloses the cloning, expression and uses of a chimeric fusion protein with superior chaperone and folding activities compared to the wild type chaperones. This invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule containing nucleotide sequences coding for a polypeptide binding segment of a non-human chaperone protein and nucleotide sequences coding for an FK506 binding protein (FKBP) or an FK506-binding-protein-like domain (FKBP-like domain).
    Type: Application
    Filed: April 11, 2011
    Publication date: August 4, 2011
    Inventors: Christian Scholz, Elke Faatz, Peter Schaarschmidt, Urban Schmitt
  • Patent number: 7947494
    Abstract: The invention discloses the cloning, expression and uses of a chimeric fusion protein with superior chaperone and folding activities compared to the wild type chaperones. This invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule comprising nucleotide sequences coding for a polypeptide binding segment of a non-human chaperone protein and nucleotide sequences coding for an FK506 binding protein (FKBP) or an FK506-binding-protein-like domain (FKBP-like domain).
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: May 24, 2011
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christian Scholz, Elke Faatz, Peter Schaarschmidt, Urban Schmitt
  • Publication number: 20110036103
    Abstract: A method of operating an ice maker including accepting a desired ice layer thickness setting, opening a water supply inlet valve to admit water from a water supply inlet, cooling an ice forming surface below freezing, directing the admitted water into a water collecting device, sensing an admitted volume of water, closing the water supply inlet valve based upon the sensed volume of admitted water and the set desired ice layer thickness, pumping water from the water collecting device to the ice forming surface via a recirculating pump, directing unfrozen water from the ice forming surface back to the water collecting device, determining a level of water in the water collecting device with a level sensor, initiating an ice harvesting routine based on input from the level sensor, operating a drain flow control device to selectively discharge water from the water collecting device to a drain outlet.
    Type: Application
    Filed: October 27, 2010
    Publication date: February 17, 2011
    Applicant: WHIRLPOOL CORPORATION
    Inventors: MELISSA MARIE BIPPUS, JOHN P. TINNEY, RAVINDRA S. KAVCHALE, MATTHEW E. HERR, BETH MICHELLE GEHLHAUSEN, GREGORY URBAN SCHMITT, BRIAN JOSEPH BEULIGMANN, ROGER URBAN MERKEL
  • Patent number: 7841198
    Abstract: An ice maker includes a refrigeration system for cooling an ice forming surface, a water supply inlet and an inlet valve arranged to selectively admit and prevent admission of water from the inlet. A flow sensor at the inlet valve determines a volume of water admitted through the water supply inlet. An operating position of the water supply inlet valve is based upon input from the flow sensor. A water collecting device receives a supply of water from the water supply inlet through the water supply inlet valve and receives a flow of water from the ice forming surface. A recirculating pump is connected to the water collecting device and to a recirculating passage arranged to direct water toward the ice forming surface. A level sensor at the water collecting device determines a level of water in the water collecting device. A discharge pump is connected to the water collecting device, and the control selectively operates the discharge pump based upon input from the level sensor.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: November 30, 2010
    Assignee: Whirpool Corporation
    Inventors: Melissa Marie Bippus, John P. Tinney, Ravindra S. Kavchale, Matthew E. Herr, Beth Michelle Gehlhausen, Gregory Urban Schmitt, Brian Joseph Beuligmann, Roger Urban Merkel
  • Publication number: 20090291892
    Abstract: Disclosed are a recombinant DNA molecule encoding a fusion protein comprising a SlpA chaperone and a target polypeptide wherein human FK506 binding proteins (FKBPs) are excluded as target polypeptides, a corresponding expression vector encoding said fusion protein as well as host cells transformed with said expression vector. Also disclosed are a method for producing the fusion protein, a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide. A further aspect of the invention is the use of the recombinantly produced fusion protein, and a reagent kit containing a recombinantly produced fusion protein comprising a SlpA chaperone and a target polypeptide.
    Type: Application
    Filed: May 6, 2009
    Publication date: November 26, 2009
    Inventors: Christian Scholz, Elke Faatz, Urban Schmitt, Peter Schaarschmidt
  • Publication number: 20090098528
    Abstract: The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.
    Type: Application
    Filed: October 11, 2007
    Publication date: April 16, 2009
    Inventors: Christoph Seidel, Ursula-Henrike Wienhues, Urban Schmitt, Manfred Motz, Michael Wiedmann, Barbara Upmeier, Erwin Soutscheck
  • Publication number: 20090042251
    Abstract: The invention discloses the cloning, expression and uses of a chimeric fusion protein with superior chaperone and folding activities compared to the wild type chaperones. This invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule comprising nucleotide sequences coding for a polypeptide binding segment of a non-human chaperone protein and nucleotide sequences coding for an FK506 binding protein (FKBP) or an FK506-binding-protein-like domain (FKBP-like domain).
    Type: Application
    Filed: July 2, 2008
    Publication date: February 12, 2009
    Inventors: Christian Scholz, Elke Faatz, Peter Schaarschmidt, Urban Schmitt