Patents by Inventor Uri Ben-David

Uri Ben-David has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA DAMAGE RESPONSE SIGNATURE GUIDED RATIONAL DESIGN OF CRISPR-BASED SYSTEMS AND THERAPIES
    Publication number: 20210147828
    Abstract: Described herein are embodiments of methods to rationally design CRISPR-Cas system-based therapeutics and therapies based on expression of a DNA-damage response signature in a cell. In some embodiments, the methods include screening a set of CRISPR-Cas systems by expressing each CRISPR-Cas system in a test cell population and modifying one or more target sequences in the test cell population; screening in the test cell population for each CRISPR-Cas system and expression of a DNA-damage response signature; and selecting one or more CRISPR-Cas systems that do not result in expression of a DNA-damage response signature.
    Type: Application
    Filed: January 13, 2021
    Publication date: May 20, 2021
    Inventors: Uri BEN-DAVID, Todd GOLUB, Rameen BEROUKHIM, Oana ENACHE, Veronica RENDO
  • SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS
    Publication number: 20180153830
    Abstract: Uses of a compound of any of Formulas I-VI as a cytotoxic inhibitor of undifferentiated cells are disclosed herein, as well as pharmaceutical compositions comprising a compound of any of Formulas I-VI, and methods for identifying a lead candidate for inhibiting undifferentiated cells. Further disclosed are uses of an SCD-1 inhibitor as a cytotoxic inhibitor of undifferentiated cells.
    Type: Application
    Filed: February 1, 2018
    Publication date: June 7, 2018
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Hoffmann-La Roche Inc.
    Inventors: Uri BEN-DAVID, Nissim BENVENISTY, Payal ARORA, Qing-Fen GAN, Ralph J. GARIPPA
  • SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS
    Publication number: 20170027890
    Abstract: Uses of a compound of any of Formulas I-VI as a cytotoxic inhibitor of undifferentiated cells are disclosed herein, as well as pharmaceutical compositions comprising a compound of any of Formulas I-VI, and methods for identifying a lead candidate for inhibiting undifferentiated cells. Further disclosed are uses of an SCD-1 inhibitor as a cytotoxic inhibitor of undifferentiated cells.
    Type: Application
    Filed: September 8, 2016
    Publication date: February 2, 2017
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Hoffmann-La Roche Inc.
    Inventors: Uri BEN-DAVID, Nissim BENVENISTY, Payal ARORA, Qing-Fen GAN, Ralph J. GARIPPA
  • Selective inhibitors of undifferentiated cells
    Patent number: 9456998
    Abstract: Uses of a compound of any of Formulas I-VI as a cytotoxic inhibitor of undifferentiated cells are disclosed herein, as well as pharmaceutical compositions comprising a compound of any of Formulas I-VI, and methods for identifying a lead candidate for inhibiting undifferentiated cells. Further disclosed are uses of an SCD-1 inhibitor as a cytotoxic inhibitor of undifferentiated cells.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: October 4, 2016
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Hoffmann-La Roche Inc.
    Inventors: Uri Ben-David, Nissim Benvenisty, Payal Arora, Qing-Fen Gan, Ralph J. Garippa
  • SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS
    Publication number: 20150148359
    Abstract: Uses of a compound of any of Formulas I-VI as a cytotoxic inhibitor of undifferentiated cells are disclosed herein, as well as pharmaceutical compositions comprising a compound of any of Formulas I-VI, and methods for identifying a lead candidate for inhibiting undifferentiated cells. Further disclosed are uses of an SCD-1 inhibitor as a cytotoxic inhibitor of undifferentiated cells.
    Type: Application
    Filed: May 22, 2013
    Publication date: May 28, 2015
    Inventors: Uri Ben-David, Nissim Benvenisty, Payal Arora, Qing-Fen Gan, Ralph J. Garippa