Abstract: The invention relates to a novel highly selective and potent NPP1 inhibitors, compositions comprising such, and their use as pharmaceuticals.

Abstract: A voltage-controlled delay line including a clipper configured to produce a clipped input voltage from an input voltage, an oscillator configured to produce a strobe pulse train that is initiated by the clipped input voltage, and a divider module configured to divide the strobe pulse train and produce an output voltage from the divided strobe pulse train.

Abstract: A disposable real-time closed catheter urine output monitoring system. The monitoring system of the invention can measure urine outputs at both high and low urine flow in real time, using a pressure chamber in the form of a hollow body having an input port for coupling to a tube connected to a catheter for collection of urine from a patient, an exit port coupled to a collection container and a vent port, such that air may flow through the vent, but urine is blocked by the vent. A sensor measures flow from the exit port of the pressure chamber into the collection container, and a pressure sensor may be included to measure pressure in the pressure chamber. The invention also provides a method of using the apparatus in a real-time monitoring system.

Abstract: A sensor for detecting a substance in a physical space, having an RF energy emitter fed by a signal source on one side of the space and an RF energy receiving element coupled to a detector at an opposite side of the channel, spaced apart by a distance (r) selected so that when the signal wavelength (?) changes based on the value of the dielectric constant (?) of the particular substance in the physical space between the emitter and receiver, the mode of field type within the sensor channel changes between near field and intermediate or far field mode.

Abstract: A disposable real-time closed catheter urine output monitoring system. The monitoring system of the invention can measure urine outputs at both high and low urine flow in real time, using a pressure chamber in the form of a hollow body having an input port for coupling to a tube connected to a catheter for collection of urine from a patient, an exit port coupled to a collection container and a vent port, such that air may flow through the vent, but urine is blocked by the vent. A sensor measures flow from the exit port of the pressure chamber into the collection container, and a pressure sensor may be included to measure pressure in the pressure chamber. The invention also provides a method of using the apparatus in a real-time monitoring system.

Abstract: A sensor for detecting a substance in a physical space, having an RF energy emitter fed by a signal source on one side of the space and an RF energy receiving element coupled to a detector at an opposite side of the channel, spaced apart by a distance (r) selected so that when the signal wavelength (?) changes based on the value of the dielectric constant (?) of the particular substance in the physical space between the emitter and receiver, the mode of field type within the sensor channel changes between near field and intermediate or far field mode.