Abstract: A method for treating a subject, the method comprises delivering an interleukin 23 (IL-23) inhibitor to the subject and applying an alternating electric field to the subject at a frequency between approximately 50 kHz and approximately 10,000 kHz.

Abstract: An apparatus for generating an electric field is disclosed. The apparatus has a plurality of elongate elements including at least a first elongate element and a second elongate element. Each elongate element of the plurality of elongate elements has a proximal end an opposed distal end, and at least one stimulation zone. The plurality of elongate elements are coupled together at their respective proximal ends. The plurality of elongate elements are selectively moveable about and between a retracted position and a deployed position. In the retracted position, the respective distal ends of the first and second elongate elements are spaced by a first distance. In the deployed position, the respective distal ends of the first and second elongate elements are spaced by a second distance that is greater than the first distance.

Abstract: An implantable apparatus for providing tumor treating fields to a target site is disclosed. The implantable apparatus includes an inflatable body having a longitudinal axis and a plurality of stimulation zones coupled to the inflatable body. The stimulation zones are configured to produce an electric field. Inflation of the body causes elongation of the body along the longitudinal axis.

Abstract: Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes. Unlike the conventional approach (in which all of the electrodes are positioned on the person's scalp) at least one of the electrodes is implemented using an implanted apparatus. The implanted apparatus includes a rigid substrate shaped and dimensioned to replace a section of the person's skull. At least one electrically conductive plate is affixed to the inner side of the rigid substrate, and a dielectric layer is disposed on the inner side of the conductive plate or plates. An electrically conductive lead is used to apply an AC voltage to the conductive plate or plates.

Abstract: A system and method are herein described. The system comprises two or more transducer arrays, each of the two or more transducer arrays comprising one or more first connector; a garment comprising a supporting layer and one or more second connector; a pump configured to selectively provide a fluid at one or more predetermined pressure; an inflatable component comprising one or more bladder and supported by the supporting layer at a location associated with the treatment area, the one or more bladder biased to a neutral position and configured to expand to an inflated position based in part on the one or more predetermined pressure, the one or more bladder in the inflated position providing a biasing pressure against a particular transducer array to cause the particular transducer array to conform to a subject's body; and a tube configured to provide fluid communication between the pump and the inflatable component.

Abstract: Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes. Unlike the conventional approach (in which all of the electrodes are positioned on the person's scalp) at least one of the electrodes is implemented using an implanted apparatus. The implanted apparatus includes a rigid substrate shaped and dimensioned to replace a section of the person's skull. At least one electrically conductive plate is affixed to the inner side of the rigid substrate, and a dielectric layer is disposed on the inner side of the conductive plate or plates. An electrically conductive lead is used to apply an AC voltage to the conductive plate or plates.

Abstract: Disclosed are methods of delivering a therapeutic to a target site of a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic from lipid capsule at the target site of the subject. Disclosed are methods of increasing target site specific release of a therapeutic agent in a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject, thereby increasing the target site specific release of the therapeutic agent.

Abstract: Tumor treating fields (TTFields) can be delivered to a subject's body with improved safety and efficacy by determining the condition of participating electrode elements and/or the subject's skin condition under positioned electrode elements. This may be accomplished by applying an AC signal to pairs or groups of electrode elements and taking corresponding impedance measurements. In some embodiments, the impedance measurements are indicative of electrode element condition and/or skin condition. These determined conditions can be used to adjust or pause TTFields treatment, for example to permit skin recovery or to ensure that participating electrode elements will properly function.

Abstract: An implantable apparatus can be positioned in a body of a patient. The apparatus can comprise a plurality of stimulation zones that are configured to provide tumor treating fields to a target site.

Abstract: Viability of cancer cells (e.g., hepatocellular carcinoma cells) can be reduced by administering sorafenib to the cancer cells and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Viability of cancer cells (e.g., hepatocellular carcinoma cells) disposed in a body of a living subject can be reduced by administering sorafenib to the subject and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Notably, experiments show that the combination of sorafenib and the alternating electric field produces synergistic results both in vitro and in vivo.

Abstract: Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes. Unlike the conventional approach (in which all of the electrodes are positioned on the person's scalp) at least one of the electrodes is implemented using an implanted apparatus. The implanted apparatus includes a rigid substrate shaped and dimensioned to replace a section of the person's skull. At least one electrically conductive plate is affixed to the inner side of the rigid substrate, and a dielectric layer is disposed on the inner side of the conductive plate or plates. An electrically conductive lead is used to apply an AC voltage to the conductive plate or plates.

Abstract: Methods of treating gastric cancer and reducing the viability of gastric cancer cells by administering folinic acid, fluorouracil, and oxaliplatin to a subject, and applying an alternating electric field to a target region of the subject are provided. In some instances, chemotherapy such as XELOX, FOLFOX and individual components thereof are administered to a subject followed by applying an alternating electric field to the subject.

Abstract: Viability of cancer cells (e.g., hepatocellular carcinoma cells) can be reduced by administering sorafenib to the cancer cells and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Viability of cancer cells (e.g., hepatocellular carcinoma cells) disposed in a body of a living subject can be reduced by administering sorafenib to the subject and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Notably, experiments show that the combination of sorafenib and the alternating electric field produces synergistic results both in vitro and in vivo.

Abstract: Molecules and compositions including same for the isolation of MCP-1 and treatment of CCR2/MCP-1 associated diseases.

Abstract: Molecules and compositions including same for the isolation of MCP-1 and treatment of CCR2/MCP-1 associated diseases.

Abstract: A system and method for providing visible indications of an area of interest for assisting the visual orientation of a user using a digital camera is provided. The system includes a digital camera having a built in illumination projector. The illumination projector optical axis is related to the camera optical axis. Typically the illumination projector is collimated with the camera. Images produced by the illumination projector are viewed by camera user and are used as a reference for understanding the camera orientation and for selecting the desirable direction and field of view (FOV) for the camera. The system and method is extremely useful for portable and wearable digital cameras as well as for setup of fixed camera applications.

Abstract: A communications system and methodology for providing improved and enhanced mobile phone call recording, storing and retrieving services to subscribers. Multiple disparate communication recorders and storage facilities, preferably located at communications network switching centers, provides selected call recording services to subscribers according to pre-selected criteria provided by said subscribers before or during said call to be recorded. The system architecture of the present invention enables optimized solution for providing recording services to large number of subscribers by utilizing large-scale traffic monitoring and filtering techniques, distributed call recording and storage that minimizes superfluous traffic within said communications network and centralized retrieval center operative to locate and retrieve recorded calls to subscribers. In addition, the system provides cross-network roaming and unified recording services, including public line/IP/mobile networks and private exchanges.