Patents by Inventor Uri Wormser
Uri Wormser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10570174Abstract: Synthetic peptides containing chemical modifications having anti-tumor properties are provided. Further provided are pharmaceutical compositions including the peptides and use thereof for treating proliferative and neoplastic diseases such as cancer.Type: GrantFiled: February 7, 2016Date of Patent: February 25, 2020Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventor: Uri Wormser
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Publication number: 20180037607Abstract: Synthetic peptides containing chemical modifications having anti-tumor properties are provided. Further provided are pharmaceutical compositions including the peptides and use thereof for treating proliferative and neoplastic diseases such as cancer.Type: ApplicationFiled: February 7, 2016Publication date: February 8, 2018Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventor: Uri WORMSER
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Patent number: 9518107Abstract: Isolated polypeptides comprising the amino acid sequence of residues 378-413 of Mus musculus ?-1-antitrypsyn (serpin A1c),active fragments thereof, and pharmaceutical compositions comprising same are described. The compositions are useful for treating burns, inflammatory, autoimmune and degenerative diseases.Type: GrantFiled: February 23, 2015Date of Patent: December 13, 2016Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM, LTD.Inventor: Uri Wormser
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Publication number: 20150239955Abstract: The present invention relates to isolated polypeptides comprising the amino acid sequence of residues 378-413 of Mus musculus ?-1-antitrypsyn (serpina1c), and active fragments thereof, and to pharmaceutical compositions comprising same. The compositions of the invention are useful for treating burns, inflammatory, autoimmune and degenerative diseases.Type: ApplicationFiled: February 23, 2015Publication date: August 27, 2015Inventor: Uri WORMSER
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Publication number: 20140256645Abstract: The invention relates to isolated peptides derived from Oryza sativa Japonica Group, pharmaceutical compositions comprising same, and uses thereof for treating, preventing, ameliorating, and/or delaying the onset of inflammatory and/or neuroinflammatory and/or autoimmune diseases or conditions and in particular multiple sclerosis. The invention further relates to extracts from Oryza sativa Japonica Group and use thereof as a dietary supplement or in a pharmaceutical composition for treating, preventing, ameliorating, and/or delaying the onset of inflammatory, and/or inflammatory, neuroinflammatory and/or autoimmune diseases or conditions. The peptides and the extract of the invention may be used for treating, ameliorating, and/or delaying the onset or preventing multiple sclerosis.Type: ApplicationFiled: May 19, 2014Publication date: September 11, 2014Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem LTD.Inventor: Uri WORMSER
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Patent number: 8765679Abstract: The invention relates to isolated peptides derived from Oryza sativa Japonica Group, pharmaceutical compositions comprising same, and uses thereof for treating, preventing, ameliorating, and/or delaying the onset of inflammatory and/or neuroinflammatory and/or autoimmune diseases or conditions and in particular multiple sclerosis. The invention further relates to extracts from Oryza sativa Japonica Group and use thereof as a dietary supplement or in a pharmaceutical composition for treating, preventing, ameliorating, and/or delaying the onset of inflammatory, and/or inflammatory, neuroinflammatory and/or autoimmune diseases or conditions. The peptides and the extract of the invention may be used for treating, ameliorating, and/or delaying the onset or preventing multiple sclerosis.Type: GrantFiled: June 29, 2010Date of Patent: July 1, 2014Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.Inventor: Uri Wormser
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Publication number: 20130203650Abstract: The present invention relates to isolated polypeptides comprising the amino acid sequence of residues 378-413 of Mus musculus ?-1-antitrypsyn (serpina1c), and active fragments thereof, and to pharmaceutical compositions comprising same. The compositions of the invention are useful for treating burns, inflammatory, autoimmune and degenerative diseases.Type: ApplicationFiled: August 30, 2011Publication date: August 8, 2013Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UVIVERSITY OF JERUSALEMInventor: Uri Wormser
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Publication number: 20130184219Abstract: The invention relates to isolated peptides derived from Oryza sativa Japonica Group, pharmaceutical compositions comprising same, and uses thereof for treating, preventing, ameliorating, and/or delaying the onset of inflammatory and/or neuroinflammatory and/or autoimmune diseases or conditions and in particular multiple sclerosis. The invention further relates to extracts from Oryza sativa Japonica Group and use thereof as a dietary supplement or in a pharmaceutical composition for treating, preventing, ameliorating, and/or delaying the onset of inflammatory, and/or inflammatory, neuroinflammatory and/or autoimmune diseases or conditions. The peptides and the extract of the invention may be used for treating, ameliorating, and/or delaying the onset or preventing multiple sclerosis.Type: ApplicationFiled: June 29, 2010Publication date: July 18, 2013Inventor: Uri Wormser
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Patent number: 7605132Abstract: Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of histone H2A and fibrinopeptide A, and preferred derivatives of these peptides are disclosed. Pharmaceutical compositions and methods of using these peptides are also disclosed. The extracts, peptides and pharmaceutical compositions according to the invention are useful for the prevention and treatment of inflammatory conditions and exposure to noxious stimuli.Type: GrantFiled: May 18, 2007Date of Patent: October 20, 2009Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Uri Wormser
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Patent number: 7528227Abstract: Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury induced by noxious stimuli when administered to animals. Pharmaceutical compositions and methods of using these peptides are also disclosed. The pharmaceutical compositions according to the invention are useful for treating and protecting against inflammatory diseases, autoimmune diseases, for treating and protecting against tissue damage, for inhibiting metalloproteinase activity, and for treating and protecting against diseases associated with the breakdown of extracellular matrix or connective tissues.Type: GrantFiled: September 25, 2006Date of Patent: May 5, 2009Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Uri Wormser
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Publication number: 20080167249Abstract: Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of histone H2A and fibrinopeptide A, and preferred derivatives of these peptides are disclosed. Pharmaceutical compositions and methods of using these peptides are also disclosed. The extracts, peptides and pharmaceutical compositions according to the invention are useful for the prevention and treatment of inflammatory conditions and exposure to noxious stimuli.Type: ApplicationFiled: May 18, 2007Publication date: July 10, 2008Inventor: Uri Wormser
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Patent number: 7238656Abstract: Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of histone H2A and fibrinopeptide A, and preferred derivatives of these peptides are disclosed. The extracts, peptides and pharmaceutical compositions according to the invention are useful for the preparation and treatment of inflammatory conditions and exposure to noxious stimuli.Type: GrantFiled: March 1, 2004Date of Patent: July 3, 2007Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Uri Wormser
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Publication number: 20070093426Abstract: Peptides derived from a segment of human histone H2A, the segment corresponding to amino acid residues 36-44 of human histone H2A, are capable of reducing or ameliorating the extent of injury induced by noxious stimuli when administered to animals. Pharmaceutical compositions and methods of using these peptides are also disclosed. The pharmaceutical compositions according to the invention are useful for treating and protecting against inflammatory diseases, autoimmune diseases, for treating and protecting against tissue damage, for inhibiting metalloproteinase activity, and for treating and protecting against diseases associated with the breakdown of extracellular matrix or connective tissues.Type: ApplicationFiled: September 25, 2006Publication date: April 26, 2007Inventor: Uri Wormser
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Patent number: 6926913Abstract: The invention provides a composition of matter comprising molecular iodine and tetraglycol.Type: GrantFiled: March 22, 2001Date of Patent: August 9, 2005Assignees: Ben Gurion University of the Negev Research & Development Authority, Yissum Research Development Company of the HebrewInventors: Uri Wormser, Amnon Sintov
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Publication number: 20050118277Abstract: Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of histone H2A and fibrinopeptide A, and preferred derivatives of these peptides are disclosed. The extracts, peptides and pharmaceutical compositions according to the invention are useful for the preparation and treatment of inflammatory conditions and exposure to noxious stimuli.Type: ApplicationFiled: March 1, 2004Publication date: June 2, 2005Inventor: Uri Wormser
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Publication number: 20040081707Abstract: The invention provides a composition of matter comprising molecular iodine and tetraglycol.Type: ApplicationFiled: November 19, 2002Publication date: April 29, 2004Inventors: Uri Wormser, Amnon Sintov
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Patent number: 6667052Abstract: The invention provides a transdermal delivery system for treating diabetes and other pathologic systemic conditions, comprising an active ingredient selected from the group consisting of peptides and proteins having an S—S bond and mixtures thereof and a pharmaceutically acceptable oxidizing agent selected from the group consisting of iodine, povidine-iodine and sources thereof, said system being essentially free of reducing agents and said oxidizing agent enabling and facilitating the penetration of said active ingredient through the skin layers and into the blood stream.Type: GrantFiled: August 10, 2001Date of Patent: December 23, 2003Assignees: Ben Gurion University of the Negev Research and Development AuthorityInventors: Amnon Sintov, Uri Wormser
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Publication number: 20020164366Abstract: The invention provides a transdermal delivery system for treating diabetes and other pathologic systemic conditions, comprising an active ingredient selected from the group consisting of peptides and proteins having an S-S bond and mixtures thereof and a pharmaceutically acceptable oxidizing agent selected from the group consisting of iodine, povidine-iodine and sources thereof, said system being essentially free of reducing agents and said oxidizing agent enabling and facilitating the penetration of said active ingredient through the skin layers and into the blood stream.Type: ApplicationFiled: August 10, 2001Publication date: November 7, 2002Inventors: Amnon Sintov, Uri Wormser
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Patent number: 6274166Abstract: A transdermal delivery system comprising an active ingredient selected from the group consisting of peptides, proteins and mixtures thereof and a pharmaceutically acceptable oxidizing agent. The transdermal delivery system is an easy-to-use topical system that facilitates the penetration of an active ingredient, such as insulin, through the skin layers and into the blood stream. Additionally, the invention includes a method for treating diabetes and other pathologic systemic conditions comprising administering an active ingredient selected from the group consisting of peptides, proteins and mixtures thereof and a pharmaceutically acceptable oxidizing agent.Type: GrantFiled: November 23, 1999Date of Patent: August 14, 2001Assignee: Ben Gurion University of the Negev Research and Development AuthorityInventors: Amnon Sintov, Uri Wormser