Patents by Inventor Uriel Malyankar

Uriel Malyankar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Anti-Angiogenic Peptides and Methods of Use Thereof

Publication number: 20080207502

Abstract: Anti-angiogenic peptides that inhibit activation or proliferation of endothelial cells are disclosed. Such peptides maybe used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR) and bFGF binding to its receptor. Such peptides may also be used to inhibit, VEGF, bFGF, or integrin activation of endothelial cells in angiogenesis-associated diseases such as cancer, leukemia, multiple myeloma, inflammatory diseases, eye diseases and skin disorders.

Type: Application

Filed: October 14, 2005

Publication date: August 28, 2008

Applicant: SOPHERION THERAPEUTICS, INC.

Inventors: Luca Rastelli, Judith Landin, Uriel Malyankar, Richard Kitson, Melissa Corso, Kenneth Brunson
METHODS AND DEVICES FOR PROMOTING ENDOTHELIAL MORPHOGENESIS

Publication number: 20070154517

Abstract: In one aspect the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial cells an amount of an osteoprotegerin sufficient to promote endothelial morphogenesis. The methods of this aspect of the invention can be practiced in vivo or in vitro. In another aspect, the present invention provides implantable medical devices that each include: (a) a device body; and (b) a layer attached to a surface of the device body, the layer comprising a molecule selected from the group consisting of osteoprotegerin and a nucleic acid molecule encoding osteoprotegerin, wherein the device is adapted to be completely or partially implanted into an animal body. The implanted medical device thus promotes the growth of blood vessels in the surrounding tissue, thereby reducing or preventing the formation of a collagenous capsule around the implanted medical device.

Type: Application

Filed: February 16, 2007

Publication date: July 5, 2007

Applicant: WASHINGTON, UNIVERSITY OF

Inventors: Uriel Malyankar, Marta Scatena, Cecilia Giachelli
Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Publication number: 20060234257

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: February 8, 2006

Publication date: October 19, 2006

Inventors: Uriel Malyankar, Xiaojia Guo, Ferenc Boldog, Nikolai Khramstsov
Anti-angiogenic peptides and methods of use thereof

Publication number: 20060172941

Abstract: Anti-angiogenic peptides that inhibit activation or proliferation of endothelial cells are disclosed. Such peptides may be used to inhibit VEGF binding to the VEGFR2 receptor (also known as the kinase domain receptor or KDR) and bFGF binding to its receptor. Such peptides may also be used to inhibit, VEGF, bFGF, or integrin activation of endothelial cells in angiogenesis-associated diseases such as cancer, leukemia, multiple myeloma, inflammatory diseases, eye diseases and skin disorders.

Type: Application

Filed: January 9, 2006

Publication date: August 3, 2006

Inventors: Luca Rastelli, Judith Landin, Uriel Malyankar, Richard Kitson, Melissa Corso, Kenneth Brunson
Novel proteins and nucleic acids encoding same

Publication number: 20060084054

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: June 4, 2003

Publication date: April 20, 2006

Inventors: John Alsobrook, David Anderson, Jason Baumgartner, Constance Berghs, Ferenc Boldog, Catherine Burgess, Stacie Casman, Elina Catterton, Mohanraj Dhanabal, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, William Grosse, Erik Gunther, Xiaojia Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Nikolai Khramtsov, William LaRochelle, Li Li, Hongping Liang, Kenneth Low, John MacDougall, Timothy Maclachlan, Uriel Malyankar, Kelly McQueeney, Amanda Mezick, Charles Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, John Peyman, Xiaozhong Qian, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Sujatha Sukumaran, Edward Szekeres, Corine Vernet, Edward Voss, Adam Wolenc, Mei Zhong, Haihong Zhong
Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Publication number: 20060063200

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: February 2, 2005

Publication date: March 23, 2006

Applicant: CuraGen Corporation

Inventors: David Anderson, Jason Baumgartner, Ferenc Boldog, Stacie Casman, Shlomit Edinger, Esha Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia Guo, Tord Hjalt, Ramesh Kekuda, Li Li, John MacDougall, Uriel Malyankar, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Carol Pena, Luca Rastelli, Richard Shimkets, David Stone, Kimberly Spytek, Corine Vernet, Edward Voss, Bryan Zerhusen
Proteins and nucleic acids encoding same

Publication number: 20060009634

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: December 21, 2004

Publication date: January 12, 2006

Inventors: Ramesh Kekuda, John Alsobrook, Velizar Tchernev, Xiaohong Liu, Kimberly Spytek, Meera Patturajan, William Grosse, Denise Lepley, Catherine Burgess, Corine Vernet, Li Li, Linda Gorman, Shlomit Edinger, Paul Sciore, Karen Ellerman, Uriel Malyankar, Mark Rothenberg, David Stone, Ferenc Boldog, Xiaojia Guo, Suresh Shenoy, David Anderson, Muralidhara Padigaru, Raymond Taupier, Charles Miller, Andrew Eisen
Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Publication number: 20060003323

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: June 3, 2003

Publication date: January 5, 2006

Inventors: John Alsobrook, Enrique Alvarez, David Anderson, Ferenc Boldog, Stacie Casman, Elina Catterton, Andrei Chapoval, Julie Crabtree-Bokor, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, Erik Gunther, Xiaojia (Sasha) Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Li Li, Xiaohong Liu, John MacDougall, Timothy Machlachlan, Uriel Malyankar, Amanda Mezick, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol Pena, John Peyman, Debasish Raha, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Paul Sciore, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Corine Vernet, Edward Voss, Mei Zhong, Hiahong Zhong
Polypeptides and nucleic acids encoding same

Publication number: 20050260713

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: April 21, 2005

Publication date: November 24, 2005

Inventors: Esha Gangolli, Meera Patturajan, Corine Vernet, Uriel Malyankar, Ramesh Kekuda, David Stone, David Anderson, Richard Shimkets, Catherine Burgess, Bryan Zerhusen, Xiaohong Liu, Kimberly Spytek, Stacie Casman, Ference Boldog, Glennda Smithson, Li Li, Weizhen Ji, John MacDougall
Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Publication number: 20050053930

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: June 3, 2003

Publication date: March 10, 2005

Inventors: David Anderson, Ferenc Boldog, Catherine Burgess, Stacie Casman, Shlomit Edinger, Andrew Eisen, Karen Ellerman, Valerie Gerlach, Linda Gorman, Xiaojia Guo, Vladimir Gusev, Weizhen Ji, Li Li, John MacDougall, Uriel Malyankar, Isabelle Millet, Tatiana Ort, Muralidhara Padigaru, Sudhirdas Prayaga, Meera Patturajan, Carol Pena, John Peyman, Daniel Rieger, Mark Rothenberg, Paul Sciore, Suresh Shenoy, Glennda Smithson, Kimberly Spytek, David Stone, Raymond Taupier, Velizar Tchernev, Corine Vernet, Edward Voss, Bryan Zerhusen, Mei Zhong
Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Publication number: 20040229779

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: August 8, 2003

Publication date: November 18, 2004

Inventors: Ramesh Kekuda, Uriel Malyankar, Li Li, David Anderson, Xiaojia (Sasha) Guo, Mei Zhong, Muralidhara Padigaru, Stacie Casman, Ferenc Boldog, Charles Miller, Nikolai Khramtsov, Corine Vernet, Meera Patturajan
Novel proteins and nucleic acids encoding same

Publication number: 20040043930

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: March 31, 2003

Publication date: March 4, 2004

Inventors: David W. Anderson, Patricia Bento, Ferenc Boldog, Catherine Burgess, Stacie Casman, Katarzyna Furtak, Linda Gorman, Bonnie Gould-Rothberg, Erik Gunther, Melvyn Heyes, Li Li, Kimberly Spytek, David Stone, Mei Zhong, Uriel Malyankar, Shlomit Edinger, Meera Patturajan, Mark Rothenberg, Glennda Smithson
Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Publication number: 20030087274

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Type: Application

Filed: July 2, 2002

Publication date: May 8, 2003

Inventors: David W. Anderson, Ferenc L. Boldog, Stacie J. Casman, Shlomit R. Edinger, Valerie Gerlach, Linda Gorman, Li Li, Uriel Malyankar, Meera Patturajan, John A. Peyman, Suresh G. Shenoy, Richard A. Shimkets, Corine A.M. Vernet, Edward Z. Voss