Patents by Inventor Urs A. Ochsner
Urs A. Ochsner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240000756Abstract: Methionyl tRNA synthetase inhibitors (MetRS) are provided for use in therapy as antibacterial agents in autism spectrum disorder.Type: ApplicationFiled: December 8, 2021Publication date: January 4, 2024Applicant: Crestone, Inc.Inventors: Nebojsa Janjic, Urs Ochsner
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Publication number: 20230193287Abstract: Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.Type: ApplicationFiled: November 17, 2022Publication date: June 22, 2023Applicant: Somalogic Operating Co., Inc.Inventors: Urs Ochsner, Louis Green, Dom Zichi, Nebojsa Janjic
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Patent number: 11655225Abstract: The present invention provides novel heterocylic amide compounds having useful antimycobacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.Type: GrantFiled: February 28, 2019Date of Patent: May 23, 2023Assignee: CRESTONE, INC.Inventors: Joshua Day, James Graham, Thale Jarvis, Elizabeth Mcfaddin, Urs Ochsner, Xicheng Sun, Christina Wong
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Patent number: 11535852Abstract: Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.Type: GrantFiled: September 16, 2020Date of Patent: December 27, 2022Assignee: Somalogic Operating Co., Inc.Inventors: Urs Ochsner, Louis Green, Dom Zichi, Nebojsa Janjic
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Publication number: 20210130829Abstract: Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.Type: ApplicationFiled: September 16, 2020Publication date: May 6, 2021Applicant: SomaLogic, Inc.Inventors: Urs Ochsner, Louis Green, Dom Zichi, Nebojsa Janjic
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Patent number: 10808251Abstract: Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.Type: GrantFiled: November 23, 2015Date of Patent: October 20, 2020Assignee: SOMALOGIC, INC.Inventors: Urs Ochsner, Louis Green, Dom Zichi, Nebojsa Janjic
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Patent number: 10538771Abstract: Described herein are compositions and methods for detecting the presence or absence of a microorganism in a sample comprising contacting the sample with an aptamer capable of binding to a cell-surface protein of the microorganism to form a complex, contacting the mixture with a second aptamer capable of binding to the first cell-surface protein or a second cell-surface protein of the microorganism; and performing an assay to detect the second aptamer, wherein detecting the second aptamer indicates that the microorganism is present in the sample, and wherein not detecting the second aptamer indicates that the microorganism is absent from the sample.Type: GrantFiled: August 31, 2018Date of Patent: January 21, 2020Assignee: SomaLogic, Inc.Inventors: Urs A. Ochsner, Nebojsa Janjic
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Patent number: 10526663Abstract: The present invention relates to a method of detecting a microorganism, in particular Staphylococcus aureus, in a sample, comprising the steps of a) incubating the sample with a slow off-rate modified aptamer (SOMAmer) comprising a fluorescent label, b) optionally washing the sample, c) analyzing the sample by a fluorescence-based detection method. The invention further relates to a slow off-rate modified aptamer comprising a fluorescent label, wherein the SOMAmer comprises a nucleotide sequence specific for Staphylococcus aureus, its use for detecting Staphylococcus aureus cells in a sample, and to a microarray or biosensor and a kit comprising at least one of such SOMAmers comprising a fluorescent label.Type: GrantFiled: February 20, 2015Date of Patent: January 7, 2020Assignees: Merck Patent GmbH, SOMALOGIC, Inc.Inventors: Anne Baumstummler, Frederic Marc-Kreucher, David Lehmann, Urs Ochsner, Nebojsa Janjic
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Patent number: 10408847Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection, treatment and diagnosis of tuberculosis (TB). In one aspect, the present application includes the identification of biomarkers that can be used alone or in various combinations for the detection of TB, including those set forth in Tables 1, 2, 4, 5, and 8 to 12. In another aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose or prognose TB or follow treatment response. In another aspect, methods are provided for diagnosing TB in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Tables 1, 2, 4, 5, and 8 to 12, wherein the individual is classified as having TB, or the likelihood of the individual having TB is determined, based on the at least one biomarker value.Type: GrantFiled: September 20, 2017Date of Patent: September 10, 2019Assignee: SomaLogic, Inc.Inventors: Urs Ochsner, David G. Sterling, Nebojsa Janjic
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Patent number: 10392621Abstract: Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first aptamer and the second aptamer comprise C-5 pyrimidine modification schemes that are different, and methods of making and using such compositions.Type: GrantFiled: February 13, 2018Date of Patent: August 27, 2019Assignee: SomaLogic, Inc.Inventors: Urs A. Ochsner, Louis S. Green, Larry Gold, Nebojsa Janjic
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Patent number: 10370669Abstract: Described herein are aptamers capable of binding to growth differentiation factor 8 (GDF8) protein; compositions comprising a GDF8 binding aptamer; and methods of making and using the same.Type: GrantFiled: February 5, 2016Date of Patent: August 6, 2019Assignee: SomaLogic, Inc.Inventors: Urs Ochsner, Louis Green, Nebojsa Janjic
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Publication number: 20190024087Abstract: Described herein are aptamers capable of binding to growth differentiation factor 11 (GDF11) protein; compositions comprising a GDF11 binding aptamer with a GDF11 protein; and methods of making and using the same.Type: ApplicationFiled: November 23, 2015Publication date: January 24, 2019Applicant: SOMALOGIC, INC.Inventors: Urs OCHSNER, Louis GREEN, Dom ZICHI, Nebojsa JANJIC
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Publication number: 20180371462Abstract: Described herein are compositions and methods for detecting the presence or absence of a microorganism in a sample comprising contacting the sample with an aptamer capable of binding to a cell-surface protein of the microorganism to form a complex, contacting the mixture with a second aptamer capable of binding to the first cell-surface protein or a second cell-surface protein of the microorganism; and performing an assay to detect the second aptamer, wherein detecting the second aptamer indicates that the microorganism is present in the sample, and wherein not detecting the second aptamer indicates that the microorganism is absent from the sample.Type: ApplicationFiled: August 31, 2018Publication date: December 27, 2018Inventors: Urs A. Ochsner, Nebojsa Janjic
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Publication number: 20180356419Abstract: The present application relates generally to biomarkers for tuberculosis (TB) infection and disease and methods of detection thereof. In various embodiments, the invention relates to one or more biomarkers, biomarker panels, methods, devices, reagents, systems, and kits for detecting and/or characterizing TB infection and/or disease.Type: ApplicationFiled: May 7, 2016Publication date: December 13, 2018Applicants: SOMALOGIC, INC., UNIVERSITY OF CAPE TOWN, SEATTLE BIOMEDICAL RESEARCH INSTITUTE D/B/A THE CENTER FOR INFECTIOUS DISEASE RESEARCHInventors: Thomas HRAHA, David STERLING, Urs A. OCHSNER, Nebojsa JANJIC, Thomas Jens SCRIBA, Adam Garth PENN-NICHOLSON, Willem Albert HANEKOM, Daniel Edward ZAK, Ethan Greene THOMPSON
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Patent number: 10093933Abstract: Described herein are compositions and methods for detecting the presence or absence of a microorganism in a sample comprising contacting the sample with an aptamer capable of binding to a cell-surface protein of the microorganism to form a complex, contacting the mixture with a second aptamer capable of binding to the first cell-surface protein or a second cell-surface protein of the microorganism; and performing an assay to detect the second aptamer, wherein detecting the second aptamer indicates that the microorganism is present in the sample, and wherein not detecting the second aptamer indicates that the microorganism is absent from the sample.Type: GrantFiled: February 14, 2015Date of Patent: October 9, 2018Assignee: SOMALOGIC, INC.Inventors: Urs A. Ochsner, Nebojsa Janjic
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Publication number: 20180187197Abstract: Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first aptamer and the second aptamer comprise C-5 pyrimidine modification schemes that are different, and methods of making and using such compositions.Type: ApplicationFiled: February 13, 2018Publication date: July 5, 2018Inventors: Urs A. Ochsner, Louis S. Green, Larry Gold, Nebojsa Janjic
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Publication number: 20180128839Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection, treatment and diagnosis of tuberculosis (TB). In one aspect, the present application includes the identification of biomarkers that can be used alone or in various combinations for the detection of TB, including those set forth in Tables 1, 2, 4, 5, and 8 to 12. In another aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose or prognose TB or follow treatment response. In another aspect, methods are provided for diagnosing TB in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Tables 1, 2, 4, 5, and 8 to 12, wherein the individual is classified as having TB, or the likelihood of the individual having TB is determined, based on the at least one biomarker value.Type: ApplicationFiled: September 20, 2017Publication date: May 10, 2018Inventors: Urs Ochsner, David G. Sterling, Nebojsa Janjic
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Patent number: 9926566Abstract: Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first aptamer and the second aptamer comprise C-5 pyrimidine modification schemes that are different, and methods of making and using such compositions.Type: GrantFiled: September 24, 2014Date of Patent: March 27, 2018Assignee: SOMALOGIC, INC.Inventors: Urs A. Ochsner, Louis S. Green, Larry Gold, Nebojsa Janjic
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Publication number: 20180016581Abstract: Described herein are aptamers capable of binding to growth differentiation factor 8 (GDF8) protein; compositions comprising a GDF8 binding aptamer; and methods of making and using the same.Type: ApplicationFiled: February 5, 2016Publication date: January 18, 2018Applicant: SOMALOGIC, INC.Inventors: Urs OCHSNER, Louis GREEN, Nebojsa JANJIC
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Publication number: 20170051337Abstract: The present invention relates to a method of detecting a microorganism, in particular Staphylococcus aureus, in a sample, comprising the steps of a) incubating the sample with a slow off-rate modified aptamer (SOMAmer) comprising a fluorescent label, b) optionally washing the sample, c) analyzing the sample by a fluorescence-based detection method. The invention further relates to a slow off-rate modified aptamer comprising a fluorescent label, wherein the SOMAmer comprises a nucleotide sequence specific for Staphylococcus aureus, its use for detecting Staphylococcus aureus cells in a sample, and to a microarray or biosensor and a kit comprising at least one of such SOMAmers comprising a fluorescent label.Type: ApplicationFiled: February 20, 2015Publication date: February 23, 2017Applicants: Merck Patent GmbH, SOMALOGIC, Inc.Inventors: Anne BAUMSTUMMLER, Frederic MARC-KREUCHER, David LEHMANN, Urs OCHSNER, Nebojsa JANJIC