Abstract: A cannula assembly includes a soft cannula, a rigid cannula, and a sealing sleeve. A soft cannula lumen surrounds at least a portion of the rigid cannula and provides a sliding connection. The sealing sleeve radially surrounds at least a portion of the soft cannula. A flange of the soft cannula has an extended wall thickness and is arranged at or near a proximal end of the soft cannula. An inner surface of the sealing sleeve engages an outer surface of the soft cannula and provides a sealing pressure radially between the rigid cannula and the soft cannula, defining a sealing area on an outer surface of the rigid cannula. A drug delivery device with the cannula assembly and an automatic insertion mechanism uses the sealing sleeve to ensure a fluid-tight, slidable connection between the soft cannula and the rigid cannula with improved sealing pressure, while allowing damage-free, cost-effective manufacturing.

Abstract: A fill port for filling a liquid medicament into a reservoir located inside a drug delivery device includes insert fixed in a passage of a wall of the drug delivery device, and a pierceable fill port sealing is sandwiched between the insert and both the housing of the drug delivery device and the reservoir to provide a fluid-tight sealing between the reservoir and the housing.

Abstract: A module for a drug delivery device includes a first housing portion with a bearing element for supporting a neck or head portion of a first end of a reservoir and a second housing portion with an elastic contact element for supporting a second end of the reservoir opposite the first end. The first and second housing portions are configured to couple to each other in an assembled state in which the first and second housing portions form a cavity for accommodating the reservoir. The bearing element and the elastic contact element may each define a limiter or limiting structure of the cavity in a longitudinal direction of the cavity to secure or hold the reservoir free of play within the cavity. The elastic contact element may be is injection molded onto a surface of a body of the second housing portion.

Abstract: An autoinjector for dispensing a liquid product includes a housing; a product container arranged in the housing, particularly, a syringe comprising a displaceable piston; a drive member; a first spring which acts on the drive member and the piston to dispense the product from the container; signal element releasably axially coupled with the drive member so that the signal element is transported in the dispensing direction as said drive member is displaced; and a second spring, which exerts a spring force on the signal element against the dispensing direction and is tensioned as the signal element is transported in the dispensing direction. When the signal element is released or detached from the axial coupling, the second spring causes the signal element to accelerate opposite the dispensing direction and strike against a signal stop and generate an acoustic and/or tactile signal.

Abstract: A modular, semi-disposable patch pump for conducting a medical therapy includes a pump unit releasably connected to a reservoir unit by means of a bayonet connection; and a housing design for supporting both reliability and ease of use of said connection.

Abstract: An insertion mechanism for a cannula includes a cannula housing, a displaceable cannula, at least one cannula holder, an insertion spring, a triggering element, and a safety device. The safety device, in a secured state, holds the triggering element in a blocked position against a force of the insertion spring and, in a released state, releases the triggering element such that the triggering element is movable into a release position by the force of said insertion energy store and the at least one cannula holder is able to move relative to the cannula housing, driven by the insertion energy store, so as to trigger or implement an insertion movement or insertion. To reach the released state, the safety mechanism is heatable by a heating element and softened and/or weakened with respect to its mechanical carrying or holding capacity, or severed or at least partially or completely melted.

Abstract: An autoinjector for dispensing a liquid product includes a housing; a product container arranged in the housing, particularly, a syringe comprising a displaceable piston; a drive member; a first spring which acts on the drive member and the piston to dispense the product from the container; signal element releasably axially coupled with the drive member so that the signal element is transported in the dispensing direction as the drive member is displaced; and a second spring, which exerts a spring force on the signal element against the dispensing direction and is tensioned as the signal element is transported in the dispensing direction. When the signal element is released or detached from the axial coupling, the second spring causes the signal element to accelerate opposite the dispensing direction and strike against a signal stop and generate an acoustic and/or tactile signal.

Abstract: An insertion mechanism for a cannula includes a cannula housing, a displaceable cannula, at least one cannula holder, an insertion spring, a triggering element, and a safety device. The safety device, in a secured state, holds the triggering element in a blocked position against a force of the insertion spring and, in a released state, releases the triggering element such that the triggering element is movable into a release position by the force of said insertion energy store and the at least one cannula holder is able to move relative to the cannula housing, driven by the insertion energy store, so as to trigger or implement an insertion movement or insertion. To reach the released state, the safety mechanism is heatable by a heating element and softened and/or weakened with respect to its mechanical carrying or holding capacity, or severed or at least partially or completely melted.

Abstract: A drug delivery device for conducting a medical therapy includes a housing with an exit port opening, and an exit port assembly, where said exit port assembly includes a rigid exit port sealing holder and a soft exit port sealing, and provides both a fluid-tight closure of the exit port opening and a fluid-tight connection between the housing and the rigid exit port sealing holder.

Abstract: A drug delivery device for conducting a medical therapy includes a housing with an exit port opening, and an exit port assembly, where said exit port assembly includes a rigid exit port sealing holder and a soft exit port sealing, and provides both a fluid-tight closure of the exit port opening and a fluid-tight connection between the housing and the rigid exit port sealing holder.

Abstract: The present invention concerns a drug delivery device with an electric brushless DC or stepper motor. A novel approach to motor control uses the micro-stepping technique in combination with over-revving the commutation of the stepper motor and reversing the rotor for a small number of microsteps with each delivery cycle. This approach has the effect of keeping the elasticity of the drive train behind the plunger in a relaxed state after completing a delivery cycle, providing better control of the movement of the rotor. Loss of steps can be avoided for a wide range of friction or speed situations, increasing the accuracy of drug delivery and making tracking of the rotor position and detecting loss of steps a much better parameter to detect blockage or occlusion. The increased controllability allows to substantially increase the motor speed for delivery, resulting in an optimum of energy efficiency while still ensuring reliable operation.

Abstract: A delivery device for administering a drug includes a housing, a reservoir and a drive device with a movable piston rod. The piston rod is guided through an aperture in an inner or outer wall of the housing. The aperture is sealed but allows the piston rod to move. The shape of the circumference of the cross-section of the piston rod is approximately a non-trivial curve of constant width.

Abstract: Shown is a simple, reliable manner of monitoring a process of expelling a variable dose of medicament from an injection device by analyzing mechanical feedback of the injection device with reduced requirements on signal data memory space and processing power. Specific measurand and mechanical user feedback sensor configurations enable sensor signal data from which individual dosage units of expelled drug are identifiable at moderate sampling rates. Preferred configurations include a force sensor adapted to measure an axial force component as applied to the device by a user pressing a proximal injection button, and a direction sensor adapted to measure an azimuth angle of an orientation of the device. The specific measurands, or process quantities observed, relate to feedback means of the device including a resilient element that produces a number of successive mechanical feedback events proportionate to a dose or quantity of drug expelled from a medicament reservoir.

Abstract: A dosing mechanism for an injection device includes a dose-setting element with a first element coupled thereto, which, during dose setting, is rotatable relative to a second element about a main rotation axis in a first direction and, during dose discharge, is fixed in rotation relative to the second element. The first and the second elements are coupled via a sleeve-shaped stop element, which forms a stop abutment. The dosing mechanism includes a stop, and the stop abutment, during the rotation of the first element in the first direction, executes a movement to a stop position where the stop abutment strikes the stop and prevents rotation of the first element relative to the second element in the first direction of rotation. The sleeve-shaped stop element is rotatable about a secondary rotation axis, which is offset parallel to or offset at an angle to the main rotation axis.

Abstract: A disposable module that can be coupled to a reusable module in order to form a pump for dispensing a medicament substance to a user in a metered manner in a coupled state, comprising a housing that encases the following components: a reservoir for receiving the substance to be dispensed; and at least one extensible cannula, which is fluidically connected to the reservoir either after being inserted or in a permanent manner. The disposable module may also comprise an electrical energy store, wherein the electrical energy necessary for the reusable module can be obtained both from the disposable module and also from a rechargeable battery in the reusable module, in order to ensure redundancy of the energy necessary for the reusable module.

Abstract: The invention is concerned with a simple and reliable manner of monitoring a handling or use of injection devices by means of a reusable electronic module. According to the invention, a displacement of a component of the injection device between an initial position and an intermediate position, and a subsequent displacement of the same component between the intermediate position and a final position essentially identical with the initial position is observed by one and the same sensor comprised in an electronic module separate from the injection device. A status or state of the injection device is then inferred in the electronic module from these two observations by way of digitally processing sensor output information. The invention thus enables secure, easy and cost-effective operation of components, devices and systems for the generation, collection and distribution of data associated with the handling or use of the injection devices.

Abstract: The invention relates to an electronic add-on module which is fitted releasably onto an automatic injection appliance before the start of injection. The add-on module comprises a force sensor for measuring a time-variable axial force component exerted on or transmitted to the attached add-on module by the injection appliance during an injection procedure. The add-on module also comprises a grip or a preferred grip position for gripping and holding the add-on module and the inserted injection appliance. The add-on module can additionally have a microphone for detection of acoustic signals. A state of the injection appliance can be determined by the add-on module solely on the basis of measurements of the axial force sensor, optionally supplemented by microphone measurements. The invention thus affords a straightforward and cost-effective way of monitoring or controlling the correct performance of an injection procedure carried out with an automatic injection appliance.

Abstract: A module for a drug delivery device includes a first housing portion with a bearing element for supporting a neck or head portion of a first end of a reservoir and a second housing portion with an elastic contact element for supporting a second end of the reservoir opposite the first end. The first and second housing portions are configured to couple to each other in an assembled state in which the first and second housing portions form a cavity for accommodating the reservoir. The bearing element and the elastic contact element may each define a limiter or limiting structure of the cavity in a longitudinal direction of the cavity to secure or hold the reservoir free of play within the cavity. The elastic contact element may be is injection molded onto a surface of a body of the second housing portion.

Abstract: A drive and metering apparatus for an injection apparatus for releasing a liquid product, the drive and metering apparatus comprising: a) a housing, b) a dose adjustment member, which is rotatable relative to the housing for adjusting the product dose to be released, c) an actuation member which is displaceable from a non-actuated position, which it assumes while adjusting the product dose to be released, into an actuated position, which it assumes while it releases the product, wherein the displacement of the actuation member into the actuated position triggers a product release and the actuation member comprises an actuation section, which is accessible to a user of the drive and metering apparatus and by means of which the user can displace the actuation member from the non-actuated position into the actuated position, d) wherein the actuation section is arranged distally in relation to the dose adjustment member.

Abstract: A modular, semi-disposable patch pump for conducting a medical therapy includes a pump unit releasably connected to a reservoir unit by means of a bayonet connection; and a housing design for supporting both reliability and ease of use of said connection.