Patents by Inventor Ursula A. Scheffel

Ursula A. Scheffel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts
    Patent number: 8524193
    Abstract: The invention provides lipophilic salts, particularly, lipophilic salts comprising a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. In certain embodiments, the cation is labeled with one or more radioisotopes. The lipophilic salts of the invention exhibit an affinity for dysfunctional mitochondria, and are useful for the imaging of cardiovascular diseases and disorders. The invention also provides pharmaceutical compositions and methods of using the lipophilic salts.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: September 3, 2013
    Assignee: The Johns Hopkins University
    Inventors: Igal Madar, Hayden T. Ravert, Robert Francis Dannals, Ursula A. Scheffel, James J. Frost
  • Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
    Patent number: 7112318
    Abstract: The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of ??m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: September 26, 2006
    Assignee: The Johns Hopkins University
    Inventors: Igal Madar, Hayden T. Ravert, Robert Francis Dannals, Ursula A. Scheffel, James J. Frost
  • Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts
    Publication number: 20050182027
    Abstract: The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of ??m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
    Type: Application
    Filed: February 6, 2003
    Publication date: August 18, 2005
    Inventors: Igal Madar, Hayden Ravert, Robert Dannals, Ursula Scheffel, J. James Frost
  • Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease
    Publication number: 20050100509
    Abstract: Methods for detecting acetylcholinesterase in a brain of a patent, comprising administering to the patient a detectable amount of a radiolabeled compound of a class of benzisoxazoles or a pharmaceutically acceptable salt thereof, are disclosed herein. The methods are useful for diagnosing, estimating the severity of, or monitoring the progression of a dementia, such as Alzheimer's disease, in a patient.
    Type: Application
    Filed: March 26, 2004
    Publication date: May 12, 2005
    Applicants: Pfizer, Inc., Pfizer Products, Inc.
    Inventors: J. Frost, Robert Dannals, John Musachio, Ursula Scheffel, Anabella Villalobos, Badreddine Bencherif
  • Non-invasive diagnostic imaging technology for mitochondria dysfunction using radiolabeled lipophilic salts
    Publication number: 20040033197
    Abstract: The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with 18F for non-invasive assessment of &Dgr;&PSgr;m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT.
    Type: Application
    Filed: February 6, 2003
    Publication date: February 19, 2004
    Applicant: The Johns Hopkins University
    Inventors: Igal Madar, Hayden T. Ravert, Robert Francis Dannals, Ursula A. Scheffel, James J. Frost
  • Radiotracers for in vivo study of acetylcholinesterase and alzheimer's disease
    Publication number: 20020064500
    Abstract: Methods for detecting acetylcholinesterase in a brain of a patient, comprising administering to the patient a detectable amount of a radiolabeled compound of a class of benzisoxazoles or a pharmaceutically acceptable salt thereof, are disclosed herein. The methods are useful for diagnosing, estimating the severity of, or monitoring the progression of a dementia, such as Alzheimer's disease, in a patient.
    Type: Application
    Filed: April 28, 2000
    Publication date: May 30, 2002
    Inventors: J. James Frost, Robert F. Dannals, John Musachio, Ursula Scheffel, Anabella Villalobos, Badreddine Bencherif