Patents by Inventor Ursula Hoffmann

Ursula Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING BTK INHIBITORS
    Publication number: 20240132508
    Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3?-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4?]bipyridinyl-2?-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided.
    Type: Application
    Filed: November 3, 2023
    Publication date: April 25, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stephan BACHMANN, Lukas CHYTIL, Serena Maria FANTASIA, Alec FETTES, Ursula HOFFMANN, Christian Oliver KAPPE, Rene LEBL, Kurt PUENTENER, Paolo TOSATTI, Jason Douglas WILLIAMS
  • Process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one compounds
    Patent number: 10538536
    Abstract: The present invention relates to a process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: January 21, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pascal Dott, Fabian Feyen, Stefan Hildbrand, Ursula Hoffmann, Fabienne Hoffmann-Emery, Roland Meier, Gerard Moine, Pankaj Rege, Georg Wuitschik
  • NOVEL PROCESS
    Publication number: 20190144468
    Abstract: The present invention relates to a process for the preparation of 2-pyrazolo[1,5-a]pyrazin-2-ylpyrido[1,2-a]pyrimidin-4-one derivatives useful as pharmaceutically active compounds.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 16, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Pascal DOTT, Fabian FEYEN, Stefan HILDBRAND, Ursula HOFFMANN, Fabienne HOFFMANN-EMERY, Roland MEIER, Gerard MOINE, Pankaj REGE, Georg WUITSCHIK
  • Process for making thienopyrimidine compounds
    Patent number: 8895729
    Abstract: Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: November 25, 2014
    Assignee: Genentech, Inc.
    Inventors: Srinivasan Babu, Zhigang Cheng, Francis Gosselin, Pirmin Hidber, Ursula Hoffmann, Theresa Humphries, Reinhard Reents, Qingping Tian, Herbert Yajima
  • Process
    Patent number: 8765989
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is a useful pharmaceutical active compound.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: July 1, 2014
    Assignee: Hoffmann - La Roche Inc.
    Inventors: Declan Costello, Gerard John Hamett, Pirmin Hidber, Ursula Hoffmann, Thomas McCarthy, Reinhard Reents, Dennis A. Smith, Timothy Smyth
  • PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS
    Publication number: 20140100366
    Abstract: Process methods for making the dual mTOR/PI3K inhibitor GDC-0980, named as (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one, having the structure: and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 10, 2014
    Applicant: Genentech, Inc.
    Inventors: Srinivasan Babu, Zhigang Cheng, Francis Gosselin, Pirmin Hidber, Ursula Hoffmann, Theresa Humphries, Reinhard Reents, Qingping Tian, Herbert Yajima
  • NOVEL PROCESS
    Publication number: 20130338391
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is a useful pharmaceutical active compound.
    Type: Application
    Filed: August 22, 2013
    Publication date: December 19, 2013
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Declan Costello, Gerard John Harnett, Pirmin Hidber, Ursula Hoffmann, Thomas McCarthy, Reinhard Reents, Dennis A. Smith, Timothy Smyth
  • Preparation for a cyclohexanecarboxylic acid derivative and intermediates
    Patent number: 8143442
    Abstract: A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: March 27, 2012
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Gerard John Harnett, Ursula Hoffmann, Michael Jansen, Reinhard Reents, Tim Sattelkau, Dennis A. Smith, Helmut Stahr
  • Process for the preparation of acid halides
    Patent number: 7977509
    Abstract: A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: July 12, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Ursula Hoffmann
  • NOVEL PROCESS
    Publication number: 20110004011
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2-ethylbutyl)cyclohexylcarbonylamino]-phenyl]2-methylthiopropionate which is a useful pharmaceutical active compound.
    Type: Application
    Filed: June 25, 2010
    Publication date: January 6, 2011
    Inventors: Declan Costello, Gerard John Harnett, Pirmin Hidber, Ursula Hoffmann, Thomas McCarthy, Reinhard Reents, Dennis A. Smith, Timothy Smyth
  • Process for the preparation of CETP(1)
    Patent number: 7863474
    Abstract: The present invention relates to a process for the preparation of 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of pharmaceutical active compounds.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: January 4, 2011
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ursula Hoffmann, Bruno Lohri
  • Process for cyclohexanecarboxylic acid derivatives
    Patent number: 7858823
    Abstract: A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: December 28, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ursula Hoffmann, Michael Jansen, Reinhard Reents, Helmut Stahr
  • Process for the production of acid chlorides
    Patent number: 7728171
    Abstract: A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: June 1, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ursula Hoffmann, Goesta Rimmler
  • PREPARATION FOR A CYCLOHEXANECARBOXYLIC ACID DERIVATIVE AND INTERMEDIATES
    Publication number: 20090253928
    Abstract: A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Application
    Filed: March 31, 2009
    Publication date: October 8, 2009
    Inventors: Gerard John Harnett, Ursula Hoffmann, Michael Jansen, Reinhard Reents, Tim Sattelkau, Dennis A. Smith, Helmut Stahr
  • PROCESS FOR CYCLOHEXANECARBOXYLIC ACID DERIVATIVES
    Publication number: 20090253927
    Abstract: A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Application
    Filed: March 31, 2009
    Publication date: October 8, 2009
    Inventors: Ursula Hoffmann, Michael Jansen, Reinhard Reents, Helmut Stahr
  • PROCESS FOR THE PREPARATION OF CETP(1)
    Publication number: 20090240080
    Abstract: The present invention relates to a process for the preparation of 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid which is useful as an intermediate in the preparation of pharmaceutical active compounds.
    Type: Application
    Filed: May 29, 2009
    Publication date: September 24, 2009
    Inventors: Ursula Hoffmann, Bruno Lohri
  • PROCESS FOR THE PREPARATION OF ACID HALIDES
    Publication number: 20090192333
    Abstract: A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Application
    Filed: April 6, 2009
    Publication date: July 30, 2009
    Inventor: Ursula Hoffmann
  • PROCESS FOR THE PRODUCTION OF ACID CHLORIDES
    Publication number: 20090036703
    Abstract: A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Application
    Filed: August 25, 2008
    Publication date: February 5, 2009
    Inventors: Ursula Hoffmann, Goesta Rimmler
  • PROCESS FOR THE PREPARATION OF ACID HALIDES
    Publication number: 20080269517
    Abstract: A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Application
    Filed: April 18, 2008
    Publication date: October 30, 2008
    Inventor: Ursula Hoffmann
  • Process for the production of acid chlorides
    Patent number: 7435849
    Abstract: A process for the preparation of acid halides of formula I which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: October 14, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ursula Hoffmann, Goesta Rimmler