Patents by Inventor Ursula Krenz
Ursula Krenz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11357755Abstract: The present invention relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids.Type: GrantFiled: June 27, 2019Date of Patent: June 14, 2022Assignee: Bayer Animal Health GmbHInventors: Joachim Telser, Ursula Krenz, Kirsten Boerngen, Andreas Turberg, Klein Sofia, Franziska Schmidt
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Patent number: 11298367Abstract: The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.Type: GrantFiled: October 17, 2018Date of Patent: April 12, 2022Assignee: Bayer AktiengesellschaftInventors: Marie-Pierre Collin-Kroepelin, Peter Kolkhof, Thomas Neubauer, Chantal Fuerstner, Elisabeth Pook, Matthias Beat Wittwer, Carsten Schmeck, Pierre Wasnaire, Heiko Schirmer, Hana Cernecka, Karoline Droebner, Hanna Tinel, Anja Buchmueller, Thomas Mondritzki, Axel Kretschmer, Klemens Lustig, Robert Fricke, Guillaume Levilain, Ursula Krenz, Norbert Witowski
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Publication number: 20220008391Abstract: The present invention relates to novel halogen-substituted compounds, to processes for their preparation and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids.Type: ApplicationFiled: June 27, 2019Publication date: January 13, 2022Inventors: Joachim TELSER, Ursula KRENZ, Kirsten BOERNGEN, Andreas TURBERG, Klein SOFIA, Franziska SCHMIDT
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Publication number: 20200338096Abstract: The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.Type: ApplicationFiled: October 17, 2018Publication date: October 29, 2020Inventors: Marie-Pierre COLLIN-KROEPELIN, Peter KOLKHOF, Thomas NEUBAUER, Chantal FUERSTNER, Elisabeth POOK, Matthias Beat WITTWER, Carsten SCHMECK, Pierre WASNAIRE, Heiko SCHIRMER, Hana CERNECKA, Karoline DROEBNER, Hanna TINEL, Anja BUCHMUELLER, Thomas MONDRITZKI, Axel KRETSCHMER, Klemens LUSTIG, Robert FRICKE, Guillaume LEVILAIN, Ursula KRENZ, Norbert WITOWSKI
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Publication number: 20170342064Abstract: The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, and their use for the treatment and/or prophylaxis of diseases.Type: ApplicationFiled: December 7, 2015Publication date: November 30, 2017Applicant: Bayer Pharma AktiengesellschaftInventors: Volker SCHULZE, Hans-Georg LERCHEN, Ulrich LÜCKING, Antje Margret WENGNER, Gerhard SIEMEISTER, Philip LIENAU, Ursula KRENZ
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Publication number: 20170240566Abstract: The present application relates to novel amino-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: ApplicationFiled: August 25, 2015Publication date: August 24, 2017Applicant: Bayer Pharma AktiengesellschaftInventors: Alexandros VAKALOPOULOS, Gaelle VALOT, Markus FOLLMANN, Damian BROCKSCHNIEDER, Johannes-Peter STASCH, Tobias MARQUARDT, Adrian TERSTEEGEN, Frank WUNDER, Lisa DIETZ, Dieter LANG, Ursula KRENZ
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Patent number: 9586958Abstract: The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or prophylaxis of diseases.Type: GrantFiled: June 6, 2014Date of Patent: March 7, 2017Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Volker Schulze, Hans-Georg Lerchen, Donald Bierer, Antje Margret Wengner, Gerhard Siemeister, Philip Lienau, Ursula Krenz, Dirk Kosemund, Detlef Stöckigt, Michael Brüning, Ulrich Lücking, Ildikó Terebesi
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Publication number: 20160207915Abstract: The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or prophylaxis of diseases.Type: ApplicationFiled: June 6, 2014Publication date: July 21, 2016Inventors: Volker Schulze, Hans-Georg Lerchen, Donald Bierer, Antje Margret Wengner, Gerhard Siemeister, Philip Lienau, Ursula Krenz, Dirk Kosemund, Detlef Stockigt, Michael Bruning, Ulrich Lucking, Ildiko Terebesi
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Publication number: 20160130230Abstract: The present application relates to novel substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders.Type: ApplicationFiled: November 16, 2015Publication date: May 12, 2016Applicant: Bayer Intellectual Property GmbHInventors: Alexandros VAKALOPOULOS, Daniel MEIBOM, Peter NELL, Frank SÜßMEIER, Barbara ALBRECHT-KÜPPER, Katja ZIMMERMANN, Joerg KELDENICH, Dirk SCHNEIDER, Ursula KRENZ
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Patent number: 9315543Abstract: The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.Type: GrantFiled: October 29, 2012Date of Patent: April 19, 2016Assignees: Bayer Intellectual Property GmbH, Bayer Pharma AktiengesellschaftInventors: Ingo Flamme, Johannes Köbberling, Hans-Georg Lerchen, Nils Griebenow, Rudolf Schohe-Loop, Sven Wittrock, Ursula Krenz
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Patent number: 9187428Abstract: The present application relates to novel substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders.Type: GrantFiled: June 27, 2011Date of Patent: November 17, 2015Assignee: Bayer Intellectual Property GmbHInventors: Alexandros Vakalopoulos, Daniel Meibom, Peter Nell, Frank Sussmeier, Barbara Albrecht-Kupper, Katja Zimmermann, Joerg Keldenich, Dirk Schneider, Ursula Krenz
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Patent number: 9096639Abstract: The invention relates to 17-hydroxy-13-methyl-17-pentafluoroethyl-11-acyloxyalkylenephenyldodecahydrocyclopenta[a]phenanthren-3-one derivatives of the formula I with progesterone-antagonizing action and to processes for preparation thereof, to use thereof for treatment and/or prophylaxis of disorders and to the use thereof for production of medicaments for treatment and/or prophylaxis of disorders, especially of fibroids of the uterus (myomas, uterine leiomyomas), endometriosis, heavy menstrual bleeds, meningiomas, hormone-dependent breast cancers and complaints associated with the menopause, or for fertility control and emergency contraception.Type: GrantFiled: July 7, 2010Date of Patent: August 4, 2015Assignee: Bayer Intellectual Property GmbHInventors: Ulrich Klar, Wolfgang Schwede, Carsten Moller, Andrea Rotgeri, Ursula Krenz
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Publication number: 20150148298Abstract: The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.Type: ApplicationFiled: February 5, 2015Publication date: May 28, 2015Applicant: SEATTLE GENETICS, INC.Inventors: Hans-Georg LERCHEN, Sherif El Sheikh, Beatrix Stelet-Ludwig, Sven Golfier, Joachim Schuhmacher, Jean Mark Gnoth, Ursula Krenz
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Publication number: 20150133364Abstract: The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.Type: ApplicationFiled: January 16, 2015Publication date: May 14, 2015Inventors: Hans-Georg LERCHEN, Ursula KRENZ, Jörg KELDENICH, Nicole DIEDRICHS, Thomas KRAHN, Claudia HIRTH-DIETRICH, Barbara ALBRECHT-KÜPPER
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Patent number: 8987209Abstract: The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.Type: GrantFiled: September 26, 2011Date of Patent: March 24, 2015Assignee: Seattle Genetics, Inc.Inventors: Hans-Georg Lerchen, Sherif El Sheikh, Beatrix Stelte-Ludwig, Sven Golfier, Joachim Schuhmacher, Jean Mark Gnoth, Ursula Krenz
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Publication number: 20150051160Abstract: The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.Type: ApplicationFiled: October 29, 2012Publication date: February 19, 2015Applicants: BAYER PHARMA AKTIENGESELLSCHAFT, BAYER INTELLECTUAL PROPERTY GMBHInventors: Ingo Flamme, Johannes Köbberling, Hans-Georg Lerchen, Nils Griebenow, Rudolf Schohe-Lop, Sven Wittrock, Ursula Krenz
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Patent number: 8957017Abstract: The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.Type: GrantFiled: March 19, 2014Date of Patent: February 17, 2015Assignee: Bayer Intellectual Property GmbHInventors: Hans-Georg Lerchen, Ursula Krenz, Jörg Keldenich, Nicole Diedrichs, Thomas Krahn, Claudia Hirth-Dietrich, Barbara Albrecht-Küpper
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Publication number: 20140296515Abstract: The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.Type: ApplicationFiled: June 17, 2014Publication date: October 2, 2014Inventors: Alexandros VAKALOPOULOS, Daniel MEIBOM, Barbara ALBRECHT-KÜPPER, Katja ZIMMERMANN, Jörg KELDENICH, Hans-Georg LERCHEN, Peter NELL, Frank SÜßMEIER, Ursula KRENZ
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Publication number: 20140206879Abstract: The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.Type: ApplicationFiled: March 19, 2014Publication date: July 24, 2014Applicant: BAYER INTELLECTUAL PROPERTY GmbHInventors: Hans-Georg LERCHEN, Ursula KRENZ, Jörg KELDENICH, Nicole DIEDRICHS, Thomas KRAHN, Claudia HIRTH-DIETRICH, Barbara ALBRECHT-KÜPPER
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Patent number: 8772498Abstract: The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.Type: GrantFiled: March 13, 2013Date of Patent: July 8, 2014Assignee: Bayer Intellectual Property GmbHInventors: Alexandros Vakalopoulos, Daniel Meibom, Barbara Albrecht-Küpper, Katja Zimmermann, Jörg Keldenich, Hans-Georg Lerchen, Peter Nell, Frank Süβmeier, Ursula Krenz