Abstract: This invention describes the use of a once-a-month injection (once-a-month injectable) that contains an estrogenic and gestagenic component as an active ingredient for the production of a pharmaceutical agent for contraception and simultaneous hormone replacement therapy for perimenopausal and premenopausal women.

Abstract: This invention describes the use of a once-a-month injection (once-a-month injectable) that contains an estrogenic and gestagenic component as an active ingredient for the production of a pharmaceutical agent for contraception and simultaneous hormone replacement therapy for perimenopausal and premenopausal women.

Abstract: A multistage combination preparation is useful for oral contraception and comprises a surprisingly low amount of gestodene as the gestagen and comprises ethinylestradiol as the estrogen.

Abstract: In order to prolong the effectiveness of depot preparations of progestagens in an oily, unsaturated solution for intramuscular injection having long-term effectiveness sufficient for a desired purpose, the volume of the injection solution is increased such that the duration of the progestational activity is increased to at least 13 weeks while retaining the same quantity of active agent to be administered.

Abstract: Relief from climacteric disturbances is achieved by administration of first a combination of an estrogen of type 1 and an estrogen of type 2, approximately in a ratio of 2:1 to 1:8, daily over 10-12 days; then a combination of an estrogen of type 1 and an estrogen of type 2, approximately in a ratio of 2:1 to 1:8, and a progestogen, daily over 9-11 days; and thereafter an estrogen of type 2, or a placebo, daily over 6-8 days.

Abstract: Reliable relief of physical and psychological menopausal disturbances is achieved by administering a combination of estradiol estrogen or derivatives of estradiol (type 1) and estriol or a derivative of estriol (type 2) in a ratio of approximately 1 : 1 to 1 : 10 for 21 days and thereafter an estrogen of type 2, a placebo or no hormone for 7 days. Administration of the dosage for 28 days permits adaptation to the normal cycle of the female.

Abstract: Method of contraception over a 21-day cycle in which an estrogen and a progestogen are administered in a low dosage for 10-12 days and thereafter at a slightly higher dosage for the next 11-9 days.

Abstract: Method of contraception in which an estrogen and a progestagen are orally administered daily for 21 days, the first 4-6 days at a low contraceptively effective daily dose, the next 4-6 days at a daily estrogen dose 1-2 times and a daily progestrogen dose 1-1.5 times that of the first 4-6 days, and for the next 9-11 days at a daily estrogen dose from that of the first 4-6 days to that of the next 4-6 days and a daily progestogen dose higher than either prior daily dose, up to 3 times that of the initial dose, followed by 7 days without hormone administration.

Abstract: Oral contraceptive consisting essentially in admixture with a pharmaceutically acceptable carrier, of 21-23 separate dosage units adapted for oral ingestion, containing an amount of an estrogen corresponding in activity to 0.030-0.050 mg. 17.alpha.-ethinylestradiol, with the first 10-12 dosage units being in combination with a gestagen corresponding in activity to about 0.050-0.125 mg. of d-norgestrel and the remainder in combination with a gestagen corresponding in activity to 2-3 times the amount of gestagen in the first 10-12 units.