Patents by Inventor Ursula Markau

Ursula Markau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermostable DNA polymerase from anaerocellum thermophilum
    Publication number: 20050019789
    Abstract: A thermostable enzyme is provided which is derived from the microorganism Anaerocellum thermophilum. The enzyme has a molecular weight of 96 to 100 kDa, shows DNA polymerase activity and reverse transcriptase activity in the presence of magnesium ions. The enzyme may be native or recombinant, and may be used with selected primers and nucleoside triphosphates in a temperature cycling polymerase chain reaction on DNA or RNA as template with or without additional DNA polymerases as an enzyme mixture.
    Type: Application
    Filed: February 2, 2004
    Publication date: January 27, 2005
    Applicant: Roche Diagnostics GMBH
    Inventors: Waltraud Ankenbauer, Gudrun Schmitz-Agheguian, Elizaveta Bonch-Osmolovskaya, Vitaly Svetlichny, Ursula Markau, Bernhard Angerer, Astrid Reiser
  • Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
    Patent number: 6794177
    Abstract: A purified DNA polymerase exhibiting reverse transcriptase activity in the presence of magnesium ions and/or manganese ions having reduced or no 5′-3′-exonuclease activity and substantially no RNaseH activity and obtainable from Carboxydothermus hydrogenoformans.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: September 21, 2004
    Assignee: Roche Diagnostics GmbH
    Inventors: Ursula Markau, Christine Ebenbichler, Gunthar Achhammer, Waltraud Ankenbauer
  • Thermostable DNA polymerase from anaerocellum thermophilum
    Patent number: 6692932
    Abstract: A thermostable enzyme is provided which is derived from the microorganism Anaerocellum thermophiluml. The enzyme has a molecular weight of 96 to 100 kDa, shows DNA polymerase activity and reverse transcriptase activity in the presence of magnesium ions. The enzyme may be native or recombinant, and may be used with selected primers and nucleoside triphosphates in a temperature cycling polymerase chain reaction on DNA or RNA as template with or without additional DNA polymerases as an enzyme mixture.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: February 17, 2004
    Inventors: Waltraud Ankenbauer, Gudrun Schmitz-Agheguian, Elizaveta Bonch-Osmolovskaya, Vitaly Svetlichny, Ursula Markau, Bernhard Angerer, Astrid Reiser
  • Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
    Publication number: 20020160399
    Abstract: A purified DNA polymerase exhibiting reverse transcriptase activity in the presence of magnesium ions and/or manganese ions having reduced or no 5′-3′-exonuclease activity and substantially no RNaseH activity and obtainable from Carboxydothermus hydrogenoformans.
    Type: Application
    Filed: February 5, 2002
    Publication date: October 31, 2002
    Inventors: Ursula Markau, Christine Ebenbichler, Gunthar Achhammer, Waltraud Ankenbauer
  • Thermostable DNA polymerase from carboxydothermus hydrogenoformans
    Patent number: 6468775
    Abstract: A DNA polymerase from a thermophilic eubacterium is provided. The DNA polymerase shows magnesium ion dependent reverse transcriptase activity and 3′-5′ exonuclease activity. The invention also includes recombinant plasmids and transformed host cells capable of producing the enzyme. The enzyme is classified into class EC 2.7.7.7., a DNA nucleotidyl transferase DNA-directed type.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: October 22, 2002
    Assignee: Roche Molecular Systems Inc.
    Inventors: Waltraud Ankenbauer, Ursula Markau, Vitaly Svetlichny, Gudrun Schmitz-Agheguian, Astrid Reiser, Bernhard Angerer, Christine Ebenbichler, Frank Laue, Elizaveta Bonch-Osmolovskaya
  • Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction
    Patent number: 6399320
    Abstract: A purified DNA polymerase exhibiting reverse transcriptase activity in the presence of magnesium ions and/or manganese ions having reduced or no 5′-3′-exonuclease activity and substantially no RNaseH activity and obtainable from Carboxydothermus hydrogenoformans.
    Type: Grant
    Filed: December 1, 1998
    Date of Patent: June 4, 2002
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ursula Markau, Christine Ebenbichler, Gunthar Achhammer, Waltraud Ankenbauer