Patents by Inventor Ursula Schmeissner

Ursula Schmeissner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced secretion of heterologous proteins by hosts using substituted promoters
    Patent number: 5082783
    Abstract: Improved secretion of heterologous proteins by hosts such as yeast by using promoters of at most intermediate strength with heterologous DNA secretion signal sequences is disclosed. A promoter of at most intermediate strength, such as the actin (ACT) or iso-1-cytochrome c (CYC1) promoter in S. cerevisiae is operatively linked to a DNA signal sequence, such as the Mf.alpha.1 signal sequence. A DNA sequence for a selected protein, such as somatomedin C (SMC), tissue plasminogen activator (TPA) or tumor necrosis factor (TNF), may be operatively linked to the DNA signal sequence.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: January 21, 1992
    Assignee: Biogen, Inc.
    Inventors: Joachim F. Ernst, Ursula Schmeissner