Patent number: 6228877
Abstract: Compounds of the formula
wherein
R1 and R1′ are independently alkyl, aryl, alkenyl or alkynyl;
R2 and R2′ are independently hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl, haloalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, acylaminoalkyl, alkylsulphonylaminoalkyl, arylsulphonyl-aminoalkyl, mercaptoalkyl, alkylthioalkyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, alkylthio or alkylsulphinyl;
R4, R5, R6, R7, R4′, R5′, R6′, and R7′ each independently are hydrogen,
CO2R9, CH2OR10, CHO, CH2NR11R12, CON(R13)2, halogen, cyano, aryl, alkyl, hydroxy, alkoxy, aryloxy, haloalkyl, nitro, amino, aralkyloxy, acylamino, monoalkylamino, dialkylamino, thio, alkyl, alkylsulphinyl, alkylsulphonyl, arylsulphinyl, azide, phosphate or phosphonate provided that at least one of R4, R5, R6 and R7 and at least one of R4′, R5′, R6′, and R7′ are other than hydrogen, with the proviso that when R6 is methoxy, R5
Type:
Grant
Filed:
December 22, 1998
Date of Patent:
May 8, 2001
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Urvashi Hooda Dhingra, Donna Mary Huryn, Dennis Dalton Keith