Patents by Inventor Usamah S. Kagyali

Usamah S. Kagyali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for assessing the role of calcineurin immunosuppression and neurotoxicity
    Patent number: 6444870
    Abstract: The present invention relates to a method of identifying drugs or agents which have immuno-suppressive effects through or as a result of their effect on calcineurin, including drugs which affect the calcineurin A&agr; (CNA&agr;) subunit or the calcineurin A&bgr; (CNA&bgr;) subunit. In addition, the present invention relates to a method of identifying drugs which reduce (partially or totally) phosphorylation of the microtubule-associated protein tau, in the nervous system of a mammal; a method of identifying drugs which reduce (partially or totally) paired helical filament formation in the nervous system of a mammal; and a method of identifying drugs which reduce (partially or totally) formation of paired helical filaments, amyloid deposits or both. The present invention also relates to transgenic non-human mammals, such as rodents and particularly mice, which lack a functional calcineurin gene and, thus, have disyrupted calcineurin expression.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: September 3, 2002
    Assignee: President and Fellows of Harvard College
    Inventors: Wei Zhang, Jonathan G. Seidman, Usamah S. Kagyali, Huntington Potter