Patents by Inventor Usman Shabon

Usman Shabon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular cloning of a 7TM receptor (AXOR34) and screening methods thereof
    Patent number: 6881827
    Abstract: AXOR34 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR34 polypeptides and polynucleotides in diagnostic assays. Further disclosed are screening assays to identify agonists and antagonists of the interaction between AXOR34 and its ligands, NmU-8, NmU-25, and NmU-23.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: April 19, 2005
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Nabil Elshourbagy, Usman Shabon, Robert S. Ames, Henry S. Sarau, Lisa Vawter, David Michalovich
  • MOLECULAR CLONING OF A 7TM RECEPTOR (AXOR34) AND SCREENING METHODS THEREOF
    Publication number: 20050049188
    Abstract: AXOR34 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR34 polypeptides and polynucleotides in diagnostic assays. Further disclosed are screening assays to identify agonists and antagonists of the interaction between AXOR34 and its ligands, NmU-8, NmU-25, and NmU-23.
    Type: Application
    Filed: August 9, 2002
    Publication date: March 3, 2005
    Inventors: Nabil Elshourbagy, Usman Shabon, Robert Ames, Henry Sarau, Lisa Vawter, David Michalovich
  • Molecular cloning of a 7TM receptor (AxOR34) and screening methods thereof
    Patent number: 6461836
    Abstract: AXOR34 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR34 polypeptides and polynucleotides in diagnostic assays. Further disclosed are screening assays to identify agonists and antagonists of the interaction between AXOR34 and its ligands, NmU-8, NmU-25, and NmU-23.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: October 8, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Nabil Elshourbagy, Usman Shabon, Robert S. Ames, Henry S. Sarau, Lisa Vawter, David Michalovich
  • Molecular cloning of a galanine-like 7 transmembrane receptor (AXOR12 RAT)
    Publication number: 20020106766
    Abstract: Rattus norvegicus AXOR12-RAT polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Rattus norvegicus AXOR12-RAT. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.
    Type: Application
    Filed: August 16, 2001
    Publication date: August 8, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon
  • Polynucleotides encoding mouse urotensin-II Receptor (UTB-R)
    Patent number: 6428982
    Abstract: Urotensin-II Receptor (UTB-R) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Urotensin-II Receptor (UTB-R) polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: June 6, 2000
    Date of Patent: August 6, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Nabil Elshourbagy, Usman Shabon, Derk J. Bergsma
  • 7TM receptor (AXOR23)
    Publication number: 20020098538
    Abstract: AXOR23 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR23 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: January 24, 2001
    Publication date: July 25, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon, David Michalovich
  • Monkey urotensin II
    Publication number: 20020058323
    Abstract: Macaca fascicularis Urotensin II polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Macaca fascicularis Urotensin II. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: hypothalamic disorders of growth hormone deficiency; mental illness, and enhanced or exaggerated sensitivity to pain.
    Type: Application
    Filed: May 11, 2001
    Publication date: May 16, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon
  • Mouse CC-CKR5 receptor polypeptide
    Patent number: 6388055
    Abstract: Mouse CC-CKR5 polypeptides and DNA (RNA) encoding such mouse CC-CKR5 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such mouse CC-CKR5 in the development of gene knockout mice for use as a model for human immunodeficiency virus.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: May 14, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J. Bergsma, Mary E. Brawner, Usman Shabon
  • Molecular cloning of a chemokine like 7TMR (AXOR87)
    Publication number: 20020052022
    Abstract: AXOR87 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR87 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: May 22, 2001
    Publication date: May 2, 2002
    Inventors: Nabil Elshourbagy, Mahanandeshwar Gattu, Usman Shabon, Diane M. Ignar
  • Molecular cloning of a chemokine receptor (SBELEVTM)
    Publication number: 20020052330
    Abstract: The SBELEVTM polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SBELEVTM polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: March 14, 2001
    Publication date: May 2, 2002
    Inventors: David Michalovich, Nabil Elshourbagy, Usman Shabon
  • Cloning of a novel 7TM receptor AXOR-2
    Publication number: 20020042385
    Abstract: AXOR-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilising AXOR-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: January 12, 2001
    Publication date: April 11, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon, Derk J. Bergsma
  • Molecular cloning of a mouse seven transmembrane receptor (AXOR70)
    Publication number: 20020037550
    Abstract: mouse AXOR70 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing mouse AXOR70 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: March 1, 2001
    Publication date: March 28, 2002
    Inventors: Nabil Elshourbagy, Mahanandeeshwar Gattu, Usman Shabon
  • Mouse neuromedin U-Variant
    Publication number: 20020019032
    Abstract: Mus musculus NeuromedinU-V polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus musculus NeuromedinU-V.
    Type: Application
    Filed: April 20, 2001
    Publication date: February 14, 2002
    Inventors: Nabil A. Elshourbagy, Usman Shabon
  • Cloning of a monkey 7TM receptor (AXOR8)
    Publication number: 20020004222
    Abstract: AXOR8 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR8 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: January 18, 2001
    Publication date: January 10, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon
  • YAK-1 related serine/threonine protein kinase-HTLAR33
    Patent number: 6297036
    Abstract: HTLAR33 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also, disclosed are methods for utilizing HTLAR33 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: October 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Bergsma, Usman Shabon
  • Molecular cloning of a galanin like 7TM receptor (AXOR40)
    Publication number: 20010016337
    Abstract: AXOR40 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR40 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: January 22, 2001
    Publication date: August 23, 2001
    Inventors: Nabil Elshourbagy, Usman Shabon, David Michalovich
  • Cloning of a novel G-protein coupled 7TM Receptor
    Publication number: 20010016319
    Abstract: HNHCI32 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNHCI32 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Application
    Filed: December 21, 2000
    Publication date: August 23, 2001
    Inventors: Usman Shabon, Derk J. Bergsma, Ganesh M. Sathe
  • Membrane-type matrix metalloproteinase-5 gene
    Patent number: 6214600
    Abstract: HCE3P83 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HCE3P83 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimer's Disease, stroke, cancer, inflammation, arthritis, musculoskeletal disease, heart disease and kidney disease, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: April 10, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Anne Romanic Arnold, Anthony Joseph Arleth, Usman Shabon
  • Human neurotensin receptor type 2 and splice variants thereof
    Patent number: 6166182
    Abstract: Human neurotensin type 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human neurotensin type 2 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Jon Bergsma, Usman Shabon
  • Human protein kinase HOACF72
    Patent number: 6159716
    Abstract: hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: December 12, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Caretha L. Creasy, George P. Livi, Damien J. Dunnington, Usman Shabon