Patents by Inventor Ute Christmann

Ute Christmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having multimodal activity against pain
    Patent number: 12479830
    Abstract: The present invention relates to homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having dual pharmacological activity towards both the ?2? subunit of the voltage-gated calcium channel and the sigma-1 (?1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: October 5, 2020
    Date of Patent: November 25, 2025
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Ariadna Fernandez-Donis, José-Luís Díaz-Fernández, Monica Garcia-Lopez, Sergi Rodriguez Escrich, Ute Christmann
  • New Pyridine-Sulfonamide Derivatives as Sigma Ligands
    Publication number: 20240254115
    Abstract: The present invention relates to new pyridine-sulfonamide derivatives of formula (I?) as sigma ligands having a great affinity for sigma receptors, especially the sigma-1 receptor (?1) and/or sigma-2 receptor (?2), as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 1, 2024
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: Carmen ALMANSA-ROSALES, Marina VIRGILI-BERNADÓ, Mónica ALONSO-XALMA, Ute CHRISTMANN
  • 1H-PYRAZOLE DERIVATIVES AS SIGMA LIGANDS
    Publication number: 20240239781
    Abstract: The present invention relates to new 1H-pyrazole derivatives of formula (I) as sigma ligands having a great affinity for sigma receptors, especially the sigma-1 receptor (?1) and/or sigma-2 receptor (?2), as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: April 19, 2022
    Publication date: July 18, 2024
    Inventors: Ana Virginia LLORENTE-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Mónica GARCÍA-LÓPEZ, Ute CHRISTMANN, Jose Luís DÍAZ-FERNÁNDEZ
  • New (Homo)Piperidinyl Heterocycles as Sigma Ligands
    Publication number: 20240217959
    Abstract: The present invention relates to new compounds of formula (I) as sigma ligands having a great affinity for sigma receptors, sigma-1 receptor (?1) and/or sigma-2 receptor (?2). The present invention also refers to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: April 6, 2022
    Publication date: July 4, 2024
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: José Luis DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Ute CHRISTMANN
  • New 5,6,7,8-Tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one Derivatives as Sigma Ligands
    Publication number: 20240182489
    Abstract: The present invention relates to new 5,6,7,8-tetrahydropyrido[4?,3?:4,5]thieno[2,3d] pyrimidin-4(3H)-one derivatives as sigma ligands having a great affinity for sigma receptors, especially sigma-1 (?1), as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: March 17, 2022
    Publication date: June 6, 2024
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: Ute CHRISTMANN, Jose Luís DÍAZ-FERNÁNDEZ
  • HOMOPIPERAZINYL AND HOMOPIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20220380345
    Abstract: The present invention relates to homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having dual pharmacological activity towards both the ?2? subunit of the voltage-gated calcium channel and the sigma-1 (?1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 5, 2020
    Publication date: December 1, 2022
    Inventors: Carmen ALMANSA-ROSALES, Ariadna FERNANDEZ-DONIS, José-Luís DÍAZ-FERNÁNDEZ, Monica GARCIA-LOPEZ, Sergi RODRIGUEZ-ESCRICH, Ute CHRISTMANN
  • Tetrahydropyran and thiopyran derivatives having multimodal activity against pain
    Patent number: 10807970
    Abstract: The present invention relates to tetrahydropyran and thiopyran derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: October 20, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Monica Garcia-Lopez, Carmen Almansa-Rosales, Ana Virginia Llorente-Fernandez, Ute Christmann, Sergio Rodriguez Escrich
  • Substituted amide derivatives having multimodal activity against pain
    Patent number: 10428051
    Abstract: The present invention relates to substituted amide derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: October 1, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Monica Garcia-Lopez, Carmen Almansa-Rosales, Ana Virginia Llorente-Fernandez, Lourdes Garriga-Sanahuja, Ute Christmann
  • TETRAHYDROPYRAN AND THIOPYRAN DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190241544
    Abstract: The present invention relates to tetrahydropyran and thiopyran derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 19, 2017
    Publication date: August 8, 2019
    Inventors: Monica GARCIA-LOPEZ, Carmen ALMANSA-ROSALES, Ana Virginia LLORENTE-FERNANDEZ, Ute CHRISTMANN, Sergio RODRIGUEZ ESCRICH
  • 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders
    Patent number: 9611229
    Abstract: The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: April 4, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Antoni Torrens-Jover, Ute Christmann, Josè-Luis Diaz-Fernández, Carmen Almansa-Rosales
  • Substituted pyrano and furanoquinolines, their preparation and use as medicaments
    Patent number: 9408842
    Abstract: The present invention relates to new substituted pyrano and furanoquinolines having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: August 9, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luis Diaz-Fernández, Ute Christmann
  • SUBSTITUTED PYRANO AND FURANOQUINOLINES, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20150352098
    Abstract: The present invention relates to new substituted pyrano and furanoquinolines having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: August 20, 2015
    Publication date: December 10, 2015
    Inventors: José-Luis DIAZ-FERNÁNDEZ, Ute CHRISTMANN
  • 1,2,3-TRIAZOLE-4-AMINE DERIVATIVES FOR THE TREATMENT OF SIGMA RECEPTOR RELATED DISEASES AND DISORDERS
    Publication number: 20150353510
    Abstract: The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.
    Type: Application
    Filed: January 7, 2014
    Publication date: December 10, 2015
    Inventors: Antoni TORRENS-JOVER, Ute CHRISTMANN, Josè-Luis DIAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES
  • Substituted pyrano and furanoquinolines, their preparation and use as medicaments
    Patent number: 9193738
    Abstract: The present invention relates to new substituted pyrano and furanoquinolines having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: November 24, 2015
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luis Diaz-Fernández, Ute Christmann
  • SUBSTITUTED PYRANO AND FURANOQUINOLINES, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20150031692
    Abstract: The present invention relates to new substituted pyrano and furanoquinolines having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: January 24, 2013
    Publication date: January 29, 2015
    Inventors: José-Luis Diaz-Fernández, Ute Christmann