Patents by Inventor Ute Schellenberger
Ute Schellenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170327546Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: May 23, 2017Publication date: November 16, 2017Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: DAVID C. CERF, JAMES J. ENGLISH, CAROL A. HENDRICK, LU LIU, JARRED K. ORAL, PHILLIP A. PATTEN, BARBARA A. ROSEN, UTE SCHELLENBERGER, INGRID UDRANSZKY, JUN-ZHI WEI, GENHAI ZHU
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Patent number: 9688730Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: March 11, 2013Date of Patent: June 27, 2017Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: David C. Cerf, James J. English, Carol A. Hendrick, Lu Liu, Jarred K. Oral, Phillip A. Patten, Barbara A. Rosen, Ute Schellenberger, Ingrid A. Udranszky, Jun-Zhi Wei, Genhai Zhu
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Patent number: 9593345Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests including, but not limited to, insect pests belonging to the orders Coleoptera and Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, polynucleotide constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.Type: GrantFiled: October 14, 2013Date of Patent: March 14, 2017Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANYInventors: Takashi Yamamoto, Michi Izumi Willcoxon, Lu Liu, Ute Schellenberger, Eric Schepers, Yi Zheng
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Publication number: 20170003305Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.Type: ApplicationFiled: September 19, 2016Publication date: January 5, 2017Applicant: CRIMSON U.S. ASSETS LLCInventors: Ute Schellenberger, Eric E. Niederkofier, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
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Publication number: 20160376607Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: June 29, 2016Publication date: December 29, 2016Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ANDRE R. ABAD, ZHENGLIN HOU, LU LIU, BRAD POLAND, UTE SCHELLENBERGER, INGRID UDRANSZKY, JIMEI WANG, JUN-ZHI WEI, THOMAS C. WOLFE, WEIPING XIE, LAN ZHOU, GENHAI ZHU
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Publication number: 20160366891Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: September 11, 2014Publication date: December 22, 2016Inventors: SCOTT DIEHN, JAMES ENGKISH, LU LIU, AZALEA ONG, JARRED ORAL, BARBARA ROSEN, UTE SCHELLENBERGER, INGRID UDRANSZKY, JUN-ZHI WEI, WEIPING XIE, GENHAI ZHU
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Patent number: 9482677Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.Type: GrantFiled: February 27, 2008Date of Patent: November 1, 2016Assignee: SCIOS INC.Inventors: Ute Schellenberger, Eric E Niederkofler, Urban A Kieman, Randall W. Nelson, Jessica O'Rear
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Patent number: 9403881Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: March 14, 2013Date of Patent: August 2, 2016Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Andre R Abad, Zhenglin Hou, Lu Liu, Brad Poland, Ute Schellenberger, Ingrid Udranszky, Jimei Wang, Jun-Zhi Wei, Thomas C. Wolfe, Lan Zhou, Genhai Zhu, Weiping Xie
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Publication number: 20160186204Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: August 14, 2014Publication date: June 30, 2016Inventors: LU LIU, JESSICA O'REAR, YOUNG JUN PARK, BARBARA ROSEN, UTE SCHELLENBERGER, ERIC SCHEPERS, ZUN-ZHI WEI, WEIPING XIE, NASSER YALPANI, XIAOHONG ZHONG, GENHAI ZHU
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Publication number: 20160031949Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Inventors: Andre R. ABAD, Zhenglin HOU, Lu LIU, Brad POLAND, Ute SCHELLENBERGER, Ingrid UDRANSZKY, Jimei WANG, Jun-Zhi WEI, Thomas C. WOLFE, Weiping XIE, Lan ZHOU, Genhai ZHU
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Patent number: 9139843Abstract: The invention provides novel ?-endotoxin polypeptides, and variants and fragments thereof, obtained from Bacillus thuringiensis having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant parasitic nematodes.Type: GrantFiled: May 23, 2012Date of Patent: September 22, 2015Assignee: PIONEER HI BRED INTERNATIONAL INCInventors: Ute Schellenberger, Jun-Zhi Wei, Genhai Zhu
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Publication number: 20150259702Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests including, but not limited to, insect pests belonging to the orders Coleoptera and Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, polynucleotide constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.Type: ApplicationFiled: October 14, 2013Publication date: September 17, 2015Inventors: Takashi Yamamoto, Michi Izumi Willcoxon, Lu Liu, Ute Schellenberger, Eric Schepers, Yi Zheng
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Publication number: 20140283208Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: March 14, 2013Publication date: September 18, 2014Applicant: PIONEER HI-BRED INTERNATIONALInventors: Andre R Abad, Zhenglin Hou, Lu Liu, Brad Poland, Ute Schellenberger, Ingrid Udransky, Jimei Wang, Jun-Zhi Wei, Thomas C. Wolfe, Lan Zhou, Zhu Genhai, Weiping Xie
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Patent number: 8637739Abstract: The invention provides novel polypeptides, and variants and fragments thereof, having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant parasitic nematodes.Type: GrantFiled: July 3, 2012Date of Patent: January 28, 2014Assignee: Pioneer Hi Bred International IncInventors: Steven D. Gruver, Lu Liu, Ute Schellenberger, Jun-Zhi Wei, Wieping Xie, Genhai Zhu
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Publication number: 20140007292Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: March 11, 2013Publication date: January 2, 2014Applicant: Pioneer Hi Bred International IncInventors: David C. Cerf, James J. English, Carol A. Hendrick, Lu Liu, Jarred K. Oral, Phillip A. Patten, Barbara A. Rosen, Ute Schellenberger, Ingrid A. Udranszky, Jun-Zhi Wei, Genhai Zhu
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Publication number: 20130031667Abstract: The invention provides novel polypeptides, and variants and fragments thereof, having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant parasitic nematodes.Type: ApplicationFiled: July 3, 2012Publication date: January 31, 2013Applicant: PIONEER HI-BRED INTERNATIONAL, INCInventors: Steven D. Gruver, Lu Liu, Ute Schellenberger, Jun-Zhi Wei, Wieping Xie, Genhai Zhu
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Publication number: 20120304337Abstract: The invention provides novel ?-endotoxin polypeptides, and variants and fragments thereof, obtained from Bacillus thuringiensis having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant parasitic nematodes.Type: ApplicationFiled: May 23, 2012Publication date: November 29, 2012Applicant: Pioneer Hi-Bred International, Inc.Inventors: Ute Schellenberger, Jun-Zhi Wei, Genhai Zhu
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Publication number: 20090215182Abstract: Disclosed is a composition that synergistically prevents proteolysis or modification of peptides in sampled biological fluids using sulfonyl fluoride family protease inhibitors at high concentrations combined with at least one additional protease inhibitor of a different type, preferably a broad spectrum protease inhibitor, and a chelator. A preferred embodiment uses AEBSF at 10 mM, Benzamidine at 20 mM and EDTA as the chelator. The disclosed composition may be combined with other protease inhibitors to further modulate its specificity, for instance to additionally target acidic proteases. Additional protease inhibitors, reducing agents, stabilizers and buffering agents may be combined with the disclosed compositions in devices for sampling or testing biological fluids for levels of peptides of interest, or methods therefore. The disclosed devices, compositions and methods are of particular use in sampling and testing for the level of natriuretic peptides.Type: ApplicationFiled: February 27, 2008Publication date: August 27, 2009Inventors: Ute Schellenberger, Eric E. Niederkofler, Urban A. Kiernan, Jessica O'Rear, Randall W. Nelson
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Publication number: 20080312152Abstract: The present invention is directed to glycosylated proBNP and pharmaceutical compositions thereof. The present invention also relates to novel assays for measuring the total natriuretic activity that is present in a clinical blood sample.Type: ApplicationFiled: October 16, 2006Publication date: December 18, 2008Inventors: N. Stephen Pollitt, Rodney A. Jue, Andrew A. Protter, Jessica O"Rear, Andrew Guzzetta, Ute Schellenberger
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Publication number: 20050119165Abstract: This invention concerns novel vascular endothelial growth factor (VEGF) dimers, compositions containing such dimers, processes for making such dimers, and methods for the treatment of various diseases by administering such dimers or compositions.Type: ApplicationFiled: August 13, 2004Publication date: June 2, 2005Applicant: Scios, Inc.Inventors: Rodney Jue, Ute Schellenberger, Peter Stathis, Peter Adriaenssens, Judith Abraham, Patricia Baldwin, N. Pollitt