Abstract: The present invention relates to targeted drug delivery of a drug or therapeutic agent through medical devices coated with formulations comprising of therapeutic agent. The coating on medical devices comprises of therapeutic agent(s), affinity vehicle(s) and additives for targeted drug delivery of biologically active material(s). The invention provides a method of manufacturing the formulation, method of coating the medical devices with such formulations to achieve controlled delivery of optimum drug dose at the target site within the body, desirable drug retention on the medical devices in vivo and in vitro and desirable drug release at the target tissue in-vivo. The invention this provides a mechanism to enhance the bioavailability of the therapeutic agent at the target tissue in the treatment of restenosis thereby reduces the actual dose of the therapeutic agent and provides a very thin layer of coating on the surface of the medical device.

Abstract: The invention disclosed herein is a balloon expandable metallic stent with low and uniform strut thickness for implantation in a body lumen such as artery. The stent consists of variable geometry of scaffold structure consisting of cells with open and closed configuration across its axial length to impart differential mechanical strength to different parts. The closed cell configuration is stronger than the open cell configuration and hence offers more resistance to radial expansion than the open cell configuration. The stent is divided into distinct sections of rows of closed and open cells. By providing closed cells in the end portions and open cells in the central portion of a stent, the dog-boning effect can be eliminated. Other configurations can be created by making only one end section of the stent with closed cells. The thickness of the stent made from cobalt-chromium alloy L-605 could be reduced to as low as 35 microns with adequate radial strength as well as fatigue resistance.