Patents by Inventor Utsav SAXENA

Utsav SAXENA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE TREATMENT OF NASH WITH ADVANCED FIBROSIS AND/OR CIRRHOSIS
    Publication number: 20240150768
    Abstract: The present invention provides methods for the treatment of non-alcoholic steatohepatitis (NASH) including advanced fibrotic and/or cirrhotic stages of NASH. The methods include administration of a compound comprising a double stranded RNAi (dsRNAi) oligonucleotide, or a pharmaceutically acceptable salt thereof, to the patient. The dsRNAi oligonucleotide optionally contains an antisense strand and a sense strand, wherein the antisense strand and the sense strand form a duplex region, and wherein the antisense strand comprises a region of complementarity to a KHK mRNA target sequence.
    Type: Application
    Filed: October 10, 2023
    Publication date: May 9, 2024
    Inventors: Ingo UPHUES, Marc ABRAMS, Andre BROERMANN, Bob Dale BROWN, Kevin CRAIG, Henryk T. DUDEK, Boris FERGER, Martin Lee KOSER, Jihye PARK, Utsav SAXENA
  • DOSAGE REGIMEN FOR THE TREATMENT OF NASH
    Publication number: 20240139230
    Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.
    Type: Application
    Filed: October 10, 2023
    Publication date: May 2, 2024
    Inventors: Jens Markus BORGHARDT, Marc ABRAMS, Andre BROERMANN, Bob Dale BROWN, Kevin CRAIG, Henryk T. DUDEK, Saskia ERBEL, Boris FERGER, Felix JOST, Martin Lee KOSER, Jihye PARK, Utsav SAXENA, Bernhard SCHMID, Florian SOMMER, Stephan TENBAUM, Ingo UPHUES
  • CHEMICAL MODIFICATIONS FOR INHIBITING EXPRESSION OF ALDH2
    Publication number: 20230416752
    Abstract: This disclosure relates to chemically modified oligonucleotides, compositions, and methods useful for reducing ALDH2 expression, to treat alcoholism. Disclosed oligonucleotide for the reduction of ALDH2 expression is modified for enhanced pharmacological properties.
    Type: Application
    Filed: November 12, 2021
    Publication date: December 28, 2023
    Inventors: Bob Dale BROWN, Henryk T. DUDEK, Utsav SAXENA
  • COMPOSITIONS AND METHODS FOR INHIBITING ANGPTL3 EXPRESSION
    Publication number: 20230287425
    Abstract: Oligonucleotides are provided herein that inhibit angiopoietin-like protein 3 (ANGPTL3) expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with ANGPTL3 expression.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 14, 2023
    Inventors: Bob D. BROWN, Henryk T. DUDEK, Utsav SAXENA, Marc ABRAMS, Anton TURANOV
  • COMPOSITIONS AND METHODS FOR MODULATING APOC3 EXPRESSION
    Publication number: 20230272393
    Abstract: Oligonucleotides and compositions including the same are disclosed for inhibiting or reducing apolipoprotein C-III (APOC3) gene expression. Methods of making and using the oligonucleotides also are disclosed, particularly uses relating to treating diseases, disorders and/or conditions associated with APOC3 expression.
    Type: Application
    Filed: December 1, 2022
    Publication date: August 31, 2023
    Inventors: Bob Dale BROWN, Henryk DUDEK, Utsav SAXENA, Wen HAN
  • COMPOSITIONS AND METHODS FOR INHIBITING NUCLEAR RECEPTOR SUBFAMILY 1 GROUP H MEMBER 3 (NR1H3) EXPRESSION
    Publication number: 20230220398
    Abstract: Oligonucleotides are provided herein that inhibit NR1H3 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with NR1H3 expression.
    Type: Application
    Filed: January 6, 2023
    Publication date: July 13, 2023
    Inventors: Utsav Saxena, Henryk Dudek, Natalie Wayne Pursell, Nicole Alexis Spiegelman, Markus Robert Latta, Birgitte Andersen
  • Compositions and methods for inhibiting ALDH2 expression
    Patent number: 11661603
    Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing ALDH2 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of ALDH2 expression may be double-stranded or single-stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of ALDH2 expression may also include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat alcoholism and related conditions.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: May 30, 2023
    Assignee: Dicerna Pharmaceuticals, Inc.
    Inventor: Utsav Saxena
  • Methods and compositions for inhibiting expression of LDHA
    Patent number: 11661604
    Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing LDHA expression, particularly in hepatocytes.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: May 30, 2023
    Assignee: DICERNA PHARMACEUTICALS, INC.
    Inventors: Bob D. Brown, Henryk T. Dudek, Utsav Saxena, Natalie Pursell, Cheng Lai, Weimin Wang, Rachel Storr, Naim Nazef, Boyoung Kim
  • Compositions and methods for inhibiting nuclear receptor subfamily 1 group H member 3 (NR1H3) expression
    Patent number: 11578329
    Abstract: Oligonucleotides are provided herein that inhibit NR1H3 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with NR1H3 expression.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: February 14, 2023
    Assignees: Novo Nordisk A/S, Dicerna Pharmaceuticals, Inc.
    Inventors: Utsav Saxena, Henryk Dudek, Natalie Wayne Pursell, Nicole Alexis Spiegelman, Markus Robert Latta, Birgitte Andersen
  • COMPOSITIONS AND METHODS FOR MODULATING PNPLA3 EXPRESSION
    Publication number: 20220364098
    Abstract: Oligonucleotides and compositions including the same are disclosed for inhibiting or reducing patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene expression. Methods of making and using the oligonucleotides also are disclosed, particularly uses relating to treating diseases, disorders and/or conditions associated with PNPLA3 expression.
    Type: Application
    Filed: April 13, 2022
    Publication date: November 17, 2022
    Inventors: Utsav SAXENA, Henryk T. DUDEK, Marc ABRAMS, Anton TURANOV, Bob Dale BROWN
  • COMPOSITIONS AND METHODS FOR INHIBITING KETOHEXOKINASE (KHK)
    Publication number: 20220340909
    Abstract: Oligonucleotides are provided herein that inhibit KHK expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with KHK expression.
    Type: Application
    Filed: April 11, 2022
    Publication date: October 27, 2022
    Inventors: Bob Dale BROWN, Henryk T. DUDEK, Utsav SAXENA, Jihye PARK, Marc ABRAMS, Martin Lee KOSER
  • COMPOSITIONS AND METHODS FOR INHIBITING NUCLEAR RECEPTOR SUBFAMILY 1 GROUP H MEMBER 3 (NR1H3) EXPRESSION
    Publication number: 20220340912
    Abstract: Oligonucleotides are provided herein that inhibit NR1H3 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with NR1H3 expression.
    Type: Application
    Filed: April 19, 2022
    Publication date: October 27, 2022
    Inventors: Utsav Saxena, Henryk Dudek, Natalie Wayne Pursell, Nicole Alexis Spiegelman, Markus Robert Latta, Birgitte Andersen
  • METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF CYP27A1
    Publication number: 20220186229
    Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing CYP27A1 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of CYP27A1 expression may be double-stranded or single-stranded and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of CYP27A1 expression may also include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat hepatobiliary disease and related conditions (e.g., liver fibrosis).
    Type: Application
    Filed: February 7, 2020
    Publication date: June 16, 2022
    Inventor: Utsav SAXENA
  • Methods and compositions for inhibiting expression of LDHA
    Patent number: 11286488
    Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing LDHA expression, particularly in hepatocytes.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: March 29, 2022
    Assignee: Dicerna Pharmaceuticals, Inc.
    Inventors: Bob D. Brown, Henryk T. Dudek, Utsav Saxena, Natalie Pursell, Cheng Lai, Weimin Wang, Rachel Storr, Naim Nazef, Boyoung Kim
  • COMPOSITIONS AND METHODS FOR INHIBITING ALDH2 EXPRESSION
    Publication number: 20210380984
    Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing ALDH2 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of ALDH2 expression may be double-stranded or single-stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of ALDH2 expression may also include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat alcoholism and related conditions.
    Type: Application
    Filed: January 15, 2019
    Publication date: December 9, 2021
    Inventor: Utsav SAXENA
  • METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF LDHA
    Publication number: 20210062199
    Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing LDHA expression, particularly in hepatocytes.
    Type: Application
    Filed: September 16, 2020
    Publication date: March 4, 2021
    Inventors: Bob D. BROWN, Henryk T. DUDEK, Utsav SAXENA, Natalie PURSELL, Cheng LAI, Weimin WANG, Rachel STORR, Naim NAZEF, Boyoung KIM
  • METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF LDHA
    Publication number: 20200283775
    Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing LDHA expression, particularly in hepatocytes.
    Type: Application
    Filed: October 12, 2018
    Publication date: September 10, 2020
    Inventors: Bob D. BROWN, Henryk T. DUDEK, Utsav SAXENA, Natalie PURSELL, Cheng LAI, Weimin WANG, Rachel STORR, Naim NAZEF, Boyoung KIM