Patents by Inventor Uwe Beyer
Uwe Beyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9662621Abstract: A drug reconstitution device comprising a disposable liquid transfer unit (18) and a reusable control and drive unit (16) removably connectable to the liquid transfer unit, the liquid transfer unit including a housing (26), a docking interface (30) configured for coupling at least one of the first and second constituent containers (2, 4) to the housing (10), and a pump engine (28) and fluid flow system (36) configured for transferring liquid from the first constituent container (2) to the second constituent container (4). The control and drive unit comprises a pump drive (22) configured to drive the pump engine during a liquid transfer action, the pump drive comprising a transmission output coupling (34) removably engaged with a transmission input coupling (50) of the pump engine (28) when the liquid transfer unit and control and drive unit are connected.Type: GrantFiled: March 4, 2013Date of Patent: May 30, 2017Assignee: SENSILE PAT AGInventors: Uwe Beyer, Derek Brandt, Thomas Gerber, Franck Robin
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Publication number: 20150029816Abstract: A drug reconstitution device comprising a disposable liquid transfer unit (18) and a reusable control and drive unit (16) removably connectable to the liquid transfer unit, the liquid transfer unit including a housing (26), a docking interface (30) configured for coupling at least one of first and second constituent containers (2, 4) to the housing (10), and a pump engine (28) and fluid flow system (36) configured for transferring liquid from the first constituent container (2) to the second constituent container (4). The control and drive unit comprises a pump drive (22) configured to drive the pump engine during a liquid transfer action, the pump drive comprising a transmission output coupling (34) removably engaged with a transmission input coupling (50) of the pump engine (28) when the liquid transfer unit and control and drive unit are connected.Type: ApplicationFiled: March 4, 2013Publication date: January 29, 2015Inventors: Uwe Beyer, Derek Brandt, Thomas Gerber, Franck Robin
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Patent number: 8880371Abstract: A method for adjusting a sensor, continuous sensor or automatic measuring system in an interstitium including the steps of adjusting the steepness of a measuring curve and a standard offset (standard axis intercept) prior to the use of the sensor, continuous sensor or measuring system, and adapting the offset by a point calibration by using a reference measure or value during the use. The present invention encompasses sensors, continuous sensors or automatic measuring systems calibrated or adjusted in accordance with the method, and in some embodiments, the offset adjusted prior to use is rectified according to the difference between a value determined by the sensor, continuous sensor or measuring system taking into account the standard steepness and the reference value.Type: GrantFiled: July 26, 2006Date of Patent: November 4, 2014Assignee: Roche Diagnostics International AGInventors: Uwe Beyer, Michael Krieftewirth, Ulrich Haueter
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Patent number: 8382700Abstract: A medical device comprising a pressure generating means adapted to deliver a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.Type: GrantFiled: October 22, 2008Date of Patent: February 26, 2013Assignee: Sensile Pat AGInventors: Sigfrid Straessler, Uwe Beyer
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Publication number: 20120302844Abstract: Medical patch device mountable on skin for drug delivery or analyte sensing, including a mounting base (6) comprising a support layer (12) and an adhesive layer (14) on a mounting side (36) of the support layer, and a functional unit (4) comprising a power supply, and an electronic circuit. The adhesive layer comprises a light switchable adhesive and the support layer is formed as a light guide configured to diffuse light from one or more electronically activated light sources connected to the electronic circuit of the functional unit.Type: ApplicationFiled: January 12, 2011Publication date: November 29, 2012Inventors: Jürg Schnidrig, Franck Robin, Uwe Beyer, Derek Brandt
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Patent number: 8235936Abstract: A micro-dialysis probe extending longitudinally between a proximal probe opening and a distal probe tip and having a supply line and a drainage line for a drip-feed solution. A tube may be provided for supporting the drainage line. A dialysis section, wherein the flow channel for the drip-feed solution experiences an inversion, is formed generally between the supply line and the drainage line, in the vicinity of the distal probe tip. The supply line and the drainage line are respectively arranged substantially side by side and together form the probe shaft of the micro-dialysis probe.Type: GrantFiled: November 22, 2010Date of Patent: August 7, 2012Assignee: Roche Diagnostics International AGInventors: Rudolf Ehwald, Uwe Beyer, Andreas Thomas
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Publication number: 20120046651Abstract: A medical device comprising a pressure generating means adapted to displace a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.Type: ApplicationFiled: April 14, 2010Publication date: February 23, 2012Inventors: Uwe Beyer, Franck Robin
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Publication number: 20120022354Abstract: There is provided a medical device for measuring an analyte concentration in the subcutaneous tissue of a patient, the medical device comprising a body access unit and a processing unit. The body access unit and the processing unit are functionally connected when an analyte concentration is measured. The body access unit comprises a transcutaneous dialysis member for accessing the body of a patient. A fluid reservoir is contained at least partially in the transcutaneous dialysis member, and the fluid reservoir is at least partially bounded by a porous membrane. The fluid reservoir contains an analyte sensitive liquid. The processing unit comprises an excitation means adapted to act on a displacement member of the body access unit to generate a flow of the analyte sensitive liquid in the fluid reservoir.Type: ApplicationFiled: March 26, 2010Publication date: January 26, 2012Applicant: SENSILE PAT AGInventors: Uwe Beyer, Franck Robin, Sigfrid Straessler
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Patent number: 8017314Abstract: The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the enzyme layer from within, from a gas-filled space connected to the atmosphere and/or to an oxygen reservoir. This enables oxygen saturation of the oxidase in a low-oxygen or oxygen-free medium and/or at high analyte concentrations. The analyte diffuses into the enzyme layer in a channel or a number of channels which contain(s) water and limit(s) diffusion, wherein the channel/channels on the surface of the sensor is/are filled with a protein-impermeable, hydrophilic matrix. By increasing the channel cross-section on the surface of the sensor and/or by connecting the channel/channels to a protein-impermeable, porous, hydrophilic layer on the surface of the sensor, the effect of outer deposits on the diffusion resistance of the analyte is reduced.Type: GrantFiled: February 15, 2008Date of Patent: September 13, 2011Assignee: Roche Diagnostics International AGInventors: Peter Abel, Rudolf Ehwald, Uwe Beyer
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Patent number: 7946044Abstract: A surveying instrument includes a measuring system having a component, a support, and a mounting unit that is arranged at the support. The component is mounted on the mounting unit and the support and the mounting unit are configured such that the mounting unit is adjustable relative to the support. The instrument also includes a fine inclination sensor that is arranged at the component and is configured to measure an inclination angle of the component and to output fine inclination data. The instrument further includes a coarse inclination sensor that is arranged at the component, is configured to measure the inclination angle and to output coarse inclination data, and includes an electronic acceleration sensor. The instrument additionally includes an evaluation unit that is configured to select inclination data from the coarse inclination data and the fine inclination data and an output unit that is configured to output the inclination data.Type: GrantFiled: September 17, 2010Date of Patent: May 24, 2011Assignee: Trimble Jena GmbHInventors: Torsten Kludas, Uwe Beyer
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Patent number: 7918818Abstract: A micro-dialysis probe extending longitudinally between a proximal probe opening and a distal probe tip and having a supply line and a drainage line for a drip-feed solution. A tube may be provided for supporting the drainage line. A dialysis section, wherein the flow channel for the drip-feed solution experiences an inversion, is formed generally between the supply line and the drainage line, in the vicinity of the distal probe tip. The supply line and the drainage line are respectively arranged substantially side by side and together form the probe shaft of the micro-dialysis probe.Type: GrantFiled: January 30, 2006Date of Patent: April 5, 2011Assignee: Roche Diagnostics International AGInventors: Rudolf Ehwald, Uwe Beyer, Andreas Thomas
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Publication number: 20110067250Abstract: A surveying instrument includes a measuring system having a component, a support, and a mounting unit that is arranged at the support. The component is mounted on the mounting unit and the support and the mounting unit are configured such that the mounting unit is adjustable relative to the support. The instrument also includes a fine inclination sensor that is arranged at the component and is configured to measure an inclination angle of the component and to output fine inclination data. The instrument further includes a coarse inclination sensor that is arranged at the component, is configured to measure the inclination angle and to output coarse inclination data, and includes an electronic acceleration sensor. The instrument additionally includes an evaluation unit that is configured to select inclination data from the coarse inclination data and the fine inclination data and an output unit that is configured to output the inclination data.Type: ApplicationFiled: September 17, 2010Publication date: March 24, 2011Applicant: Trimble Jena GmbHInventors: Torsten Kludas, Uwe Beyer
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Publication number: 20100234830Abstract: A medical device comprising a pressure generating means adapted to deliver a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.Type: ApplicationFiled: October 22, 2008Publication date: September 16, 2010Applicant: Sensile Pat AGInventors: Sigfrid Straessler, Uwe Beyer
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Publication number: 20080182286Abstract: The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the enzyme layer from within, from a gas-filled space connected to the atmosphere and/or to an oxygen reservoir. This enables oxygen saturation of the oxidase in a low-oxygen or oxygen-free medium and/or at high analyte concentrations. The analyte diffuses into the enzyme layer in a channel or a number of channels which contain(s) water and limit(s) diffusion, wherein the channel/channels on the surface of the sensor is/are filled with a protein-impermeable, hydrophilic matrix. By increasing the channel cross-section on the surface of the sensor and/or by connecting the channel/channels to a protein-impermeable, porous, hydrophilic layer on the surface of the sensor, the effect of outer deposits on the diffusion resistance of the analyte is reduced.Type: ApplicationFiled: February 15, 2008Publication date: July 31, 2008Inventors: Peter Abel, Rudolf Ehwald, Uwe Beyer
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Patent number: 7335286Abstract: The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the enzyme layer from within, from a gas-filled space connected to the atmosphere and/or to an oxygen reservoir. This enables oxygen saturation of the oxidase in a low-oxygen or oxygen-free medium and/or at high analyte concentrations. The analyte diffuses into the enzyme layer in a channel or a number of channels which contain(s) water and limit(s) diffusion, wherein the channel/channels on the surface of the sensor is/are filled with a protein-impermeable, hydrophilic matrix. By increasing the channel cross-section on the surface of the sensor and/or by connecting the channel/channels to a protein-impermeable, porous, hydrophilic layer on the surface of the sensor, the effect of outer deposits on the diffusion resistance of the analyte is reduced.Type: GrantFiled: October 16, 2003Date of Patent: February 26, 2008Assignee: Disetronic Licensing AGInventors: Peter Abel, Rudolf Ehwald, Uwe Beyer
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Publication number: 20070168145Abstract: A method for adjusting a sensor, continuous sensor or automatic measuring system in an interstitium including the steps of adjusting the steepness of a measuring curve and a standard offset (standard axis intercept) prior to the use of the sensor, continuous sensor or measuring system, and adapting the offset by a point calibration by using a reference measure or value during the use. The present invention encompasses sensors, continuous sensors or automatic measuring systems calibrated or adjusted in accordance with the method, and in some embodiments, the offset adjusted prior to use is rectified according to the difference between a value determined by the sensor, continuous sensor or measuring system taking into account the standard steepness and the reference value.Type: ApplicationFiled: July 26, 2006Publication date: July 19, 2007Inventors: Uwe Beyer, Michael Krieftewirth, Ulrich Haueter
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Publication number: 20060264812Abstract: A micro-dialysis probe extending longitudinally between a proximal probe opening and a distal probe tip and having a supply line and a drainage line for a drip-feed solution. A tube may be provided for supporting the drainage line. A dialysis section, wherein the flow channel for the drip-feed solution experiences an inversion, is formed generally between the supply line and the drainage line, in the vicinity of the distal probe tip. The supply line and the drainage line are respectively arranged substantially side by side and together form the probe shaft of the micro-dialysis probe.Type: ApplicationFiled: January 30, 2006Publication date: November 23, 2006Inventors: Rudolf Ehwald, Uwe Beyer, Andreas Thomas
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Patent number: 6938463Abstract: A method and apparatus for determining solute levels by affinity viscosimetry involving a sensitive fluid, in which the sensitive fluid flows continuously through a first hydraulic resistor in the flow direction of the dialysis chamber, and the sensitive fluid modified by dialysis simultaneously flows through another resistor, wherein the pressure differences between the resistors is determined on-line with the aid of pressure sensors and converted into a relative value which is approximately proportional to the concentration of solute.Type: GrantFiled: August 30, 2002Date of Patent: September 6, 2005Assignee: Disetronic Licensing AGInventors: Rudolf Ehwald, Ulrich Haueter, Uwe Beyer
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Publication number: 20040229302Abstract: The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the enzyme layer from within, from a gas-filled space connected to the atmosphere and/or to an oxygen reservoir. This enables oxygen saturation of the oxidase in a low-oxygen or oxygen-free medium and/or at high analyte concentrations. The analyte diffuses into the enzyme layer in a channel or a number of channels which contain(s) water and limit(s) diffusion, wherein the channel/channels on the surface of the sensor is/are filled with a protein-impermeable, hydrophilic matrix. By increasing the channel cross-section on the surface of the sensor and/or by connecting the channel/channels to a protein-impermeable, porous, hydrophilic layer on the surface of the sensor, the effect of outer deposits on the diffusion resistance of the analyte is reduced.Type: ApplicationFiled: October 16, 2003Publication date: November 18, 2004Inventors: Peter Abel, Rudolf Ehwald, Uwe Beyer
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Patent number: RE47403Abstract: A method for adjusting a sensor, continuous sensor or automatic measuring system in an interstitium including the steps of adjusting the steepness of a measuring curve and a standard offset (standard axis intercept) prior to the use of the sensor, continuous sensor or measuring system, and adapting the offset by a point calibration by using a reference measure or value during the use. The present invention encompasses sensors, continuous sensors or automatic measuring systems calibrated or adjusted in accordance with the method, and in some embodiments, the offset adjusted prior to use is rectified according to the difference between a value determined by the sensor, continuous sensor or measuring system taking into account the standard steepness and the reference value.Type: GrantFiled: December 22, 2015Date of Patent: May 28, 2019Assignee: Roche Diabetes Care, Inc.Inventors: Uwe Beyer, Michael Krieftewirth, Ulrich Haueter