Patents by Inventor Uwe Bicker
Uwe Bicker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Method and system for anonymous test administration and user-enabled personal health risk assessment
Publication number: 20030217037Abstract: Methods are provided for anonymously administering at least one test for one or more test subjects. The methods can comprise registering one or more orderers by recording, in a first repository, the identity data thereof; forwarding to each of the orderers, without referencing the identity data of the one or more test subjects, a kit which comprises instructions on and materials for taking at least one sample for the test; receiving the sample from the test subject; obtaining, for each test subject, a result of the test on the sample; and recording, in a second repository, the result for each of the test subjects under a unique identification code, wherein the first repository and the second repository are insulated from each other. Also provided are systems for administering such tests, computer-readable media comprising a data structure that contains fields of data from such tests and/or computer-readable instructions for performing such tests, and test kits for performing such tests.Type: ApplicationFiled: January 21, 2003Publication date: November 20, 2003Inventors: Uwe Bicker, Matthias Pfeiffer -
Patent number: 5369119Abstract: The subject of the present invention is the use of imexon for the production of pharmaceutical compositions with an immunosuppressive action. The present invention also provides pharmaceutical compositions containing imexon and further active materials.Type: GrantFiled: March 2, 1993Date of Patent: November 29, 1994Assignee: Boehringer Mannheim GmbHInventors: Dieter Herrmann, Rainer Haag, Elmar Bosies, Uwe Bicker, Wolfgang Kampe
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Patent number: 5055290Abstract: A method of selectively suppressing the excess immune reaction produced iatrogenically or autochthonously by administering 0.1 to 100 mg of ciamexone per kg of body weight.Type: GrantFiled: May 25, 1988Date of Patent: October 8, 1991Assignee: Boehringer Mannehim GmbHInventors: Uwe Bicker, Wulf Pahlke
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Patent number: 4517183Abstract: The present invention provides pharmaceutical compositions containing N-substituted aziridine-2-carboxylic acid derivatives of the general formula: ##STR1## wherein X is a carboxyl, a cyano, an alkoxycarbonyl or an optionally substituted carbamoyl radical, R is a hydrogen atom, an aliphatic hydrocarbon radical which is saturated or can contain one or more unsaturations and can be substituted one or more times by halogen, alkoxy, hydroxyl, dialkylamino, dialkylaminoxy, cycloalkylamino, acylamino, acyl, nitro, alkylthio, alkylsulphinyl, alkylsulphonyl, cyano, carboxyl, alkoxycarbonyl or carbamoyl or by cycloalkyl or cycloalkenyl radicals optionally carrying alkyl, alkoxy or alkoxycarbonyl radicals, optionally interrupted by hetero atoms and optionally bridged, or by an aryl, hetaryl, aryloxy, arylthio, acyloxy, alkoxycarbonylamino or isothioureido radical, or R is a cycloalkyl or cycloalkenyl radical optionally substituted by alkyl, alkoxy or oxo groups, optionally interrupted by hetero atoms and optionally briType: GrantFiled: May 17, 1983Date of Patent: May 14, 1985Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Wolfgang Kampe, Max Thiel, Uwe Bicker, Dietmar Boerner
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Patent number: 4492659Abstract: The present invention provides phospholipids of the general formula: ##STR1## wherein X is a valency bond, an oxygen or sulphur atom or a sulfonyl, sulfinyl, phenylene, cycloaklylene, carbonylamino, aminocarbonyl, ureido or carbonyl group, R.sub.1 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon radical containing up to 18 carbon atoms, which is optionally substituted one or more times by halogen, alkoxy, alkylthio, alkanesulfinyl, alkanesulfonyl, carbalkoxy or phenyl, R.sub.2 is a straight-chained or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing up to 18 carbon atoms, which is optionally substituted one or more times by halogen, alkoxy, alkylthio, alkanesulphinyl, alkanesulphonyl, carbalkoxy or phenyl, Y is an oxygen atom or a --O--CO--O--, --O--CO--NH-- or --O--CS--NH-- group, R.sub.Type: GrantFiled: July 7, 1982Date of Patent: January 8, 1985Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Rudi Gall, Gunter Weimann, Uwe Bicker, Wulf Pahlke
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Patent number: 4444766Abstract: Sulfur-containing phospholipid compounds of the formula ##STR1## pharmaceutical compositions having anti-tumor activity which include said phospholipid compounds, and the method of use for combating tumors, of said phospholipid compounds.Type: GrantFiled: October 16, 1981Date of Patent: April 24, 1984Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Rudi Gall, Gunter Weimann, Uwe Bicker, Wulf Pahlke
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Patent number: 4410532Abstract: A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy;or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.Type: GrantFiled: December 28, 1981Date of Patent: October 18, 1983Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Herbert Berger, Wolfgang Kampe, Uwe Bicker, Alfred Grafe
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Patent number: 4409236Abstract: Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, andR and R.sup.1 are various organic radicals; or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl, a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R.sub.Type: GrantFiled: June 1, 1981Date of Patent: October 11, 1983Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Herbert Berger, Wolfgang Kampe, Uwe Bicker, Alfred Grafe
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Patent number: 4397848Abstract: The present invention provides pharmaceutical compositions containing N-substituted aziridine-2-carboxylic acid derivatives of the general formula: ##STR1## wherein X is a carboxyl, a cyano, an alkoxycarbonyl or an optionally substituted carbamoyl radical, R is a hydrogen atom, or an optionally substituted aliphatic hydrocarbon radical or cycloalkyl or cycloalkenyl radical, and R.sub.1 is a hydrogen atom or an alkyl or phenyl radical; and the pharmacologically acceptable salts thereof, in admixture with a pharmaceutical diluent or carrier. The present invention also provides, as new compounds, N-substituted aziridine-2-carboxylic acid derivatives of general formula (I') but with the proviso that when X is a carbamoyl or alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, R is not a methyl, ethyl, isopropyl or benzyl radical; and the pharmacologically acceptable salts thereof, and also provides processes for the preparation of these new compounds.Type: GrantFiled: February 20, 1981Date of Patent: August 9, 1983Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Wolfgang Kampe, Max Thiel, Uwe Bicker, Dietmar Boerner
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Patent number: 4376731Abstract: 2-Substituted-1-aziridine-carboxylic acid esters exhibiting immuno-stimulant activity and of the formula ##STR1## wherein X is a carbamoyl or alkoxycarbonyl radical, andR.sup.1 is an aliphatic hydrocarbon radical optionally substituted by halogen, alkoxy, amino, carbamoyloxy, cycloalkyl, hydroxyl, an imido or heterocyclic radical, cycloalkyl; or aryl, aralkyl, aryloxyalkyl or arylthioalkyl wherein the aryl moiety is optionally substituted by halogen, alkyl, alkoxy, hydroxyl, amino, nitro, cyano, acyl, carbalkoxy, thioalkyl, alkylsulphonyl, phenyl or trifluoromethyl. Counterparts where X is --CN and R.sup.1 is as above, except for ethyl, are also new.Type: GrantFiled: January 31, 1978Date of Patent: March 15, 1983Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Ruth Heerdt, Rudi Gall, Uwe Bicker, Anna E. Ziegler
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Patent number: 4370323Abstract: A 2-cyanoaziridinyl-(1)-2-substituted-aziridinyl-(1)-methane ##STR1## wherein R is a nitrile or carbamoyl group, andR.sub.1 and R.sub.2 each independently is a hydrogen atom, an aliphatic hydrocarbon radical containing up to 10 carbon atoms optionally substituted by hydroxyl, alkoxy, amino, alkylamino, dialkylamino, alkoxycarbonyl, cyano, 1, 2 or 3 halogens, cycloalkyl, phenyl or phenoxy; nitrile, carboxyl, alkoxycarbonyl or optionally hydrogenated monocyclic heteroaryl or phenyl optionally substituted by alkyl, alkoxy, hydroxy, alkoxcarbonyl, dialkylamino, alkylthio, trifluoromethyl, nitro, carbamoyl, nitrile, sulphonamido, hydroxyalkyl, methylenedioxy, or halogen; or R.sub.1 and R.sub.2, together with the carbon atom to which they are attached, form a ring containing up to 8 ring members of which at least one may be oxygen, sulphur, SO, SO.sub.Type: GrantFiled: March 9, 1977Date of Patent: January 25, 1983Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Kampe, Max Thiel, Erich Fauland, Uwe Bicker, Gottfried Hebold
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Patent number: 4321194Abstract: Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, andR and R.sup.1 are various organic radicals, or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R.sub.1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R.sub.Type: GrantFiled: July 23, 1979Date of Patent: March 23, 1982Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Herbert Berger, Wolfgang Kampe, Uwe Bicker, Alfred Grafe
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Patent number: 4282212Abstract: 1-(N-Acyl-carbamoyl)-2-cyanoaziridines of the formula ##STR1## wherein X is oxygen or sulphur,Z is hydrogen or an organic radical, andY is a carbonyl, sulphonyl, sulphinyl, sulphenyl, phosphoryl or phosphonyl radical,and salts thereof, exhibit immune-stimulating and cancerostatic activities.Type: GrantFiled: September 30, 1977Date of Patent: August 4, 1981Assignee: Boehringer Mannheim GmbHInventors: Herbert Berger, Rudi Gall, Wolfgang Kampe, Uwe Bicker, Gottfried Hebold
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Patent number: 4267174Abstract: 1-Acyl-2-cyanoaziridines of the formula ##STR1## wherein R is an acyl radical of a carboxylic, sulphonic, sulphinic, sulphenic, phosphonic or phosphoric acid,exhibit immune-stimulating and cancerostatic activities.Type: GrantFiled: June 16, 1978Date of Patent: May 12, 1981Assignee: Boehringer Mannheim, GmbHInventors: Herbert Berger, Rudi Gall, Wolfgang Kampe, Uwe Bicker, Rolf Kuhn
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Patent number: 4083987Abstract: 4-Imino-1,3-diazabicyclo[3.1.0]-hexan-2-one of one or more of the tautomeric formulas ##STR1## or a physiologically compatible salt thereof exhibits cancerostatic and immuno-stimulant activity. It is produced by cyclized 1-carboxamido-2-cyanoaziridine in an anhydrous polar organic solvent in the presence of a catalytic amount of an alkali.Type: GrantFiled: May 26, 1976Date of Patent: April 11, 1978Assignee: Boehringer Mannheim GmbHInventors: Uwe Bicker, Wolfgang Kampe, Wolfgang Steingross