Patents by Inventor Uwe Bornscheuer

Uwe Bornscheuer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARATION OF OPTICALLY ACTIVE N-PROTECTED 3-AMINOPYRROLIDINE OR OPTICALLY ACTIVE N-PROTECTED 3-AMINOPIPERIDINE AND THE CORRESPONDING KETONES BY OPTICAL RESOLUTION OF THE RACEMIC AMINE MIXTURES EMPLOYING A BACTERIAL OMEGA-TRANSAMINASE
    Publication number: 20090325224
    Abstract: The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
    Type: Application
    Filed: September 6, 2007
    Publication date: December 31, 2009
    Applicant: LONZA AG
    Inventors: Karen Robins, Uwe Bornscheuer, Matthias Höhne
  • GROUP OF ESTERASES FOR THE ENANTIOSELECTIVE PRODUCTION OF FINE AND SPECIALITY CHEMICALS
    Publication number: 20090311745
    Abstract: The present invention relates to a polynucleotide encoding an enzyme having carboxylesterase [E.C. 3.1.1.
    Type: Application
    Filed: May 3, 2007
    Publication date: December 17, 2009
    Applicant: B.R.A.I.N AG
    Inventors: Klaus Liebeton, Jürgen Eck, Uwe Bornscheuer, Dominique Böttcher, Peter Langer, Esen Bellur
  • Process for The Preparation of Optically Active Chiral Amines
    Publication number: 20090246837
    Abstract: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 1, 2009
    Inventors: Karen Robins, Uwe Bornscheuer, Matthias Höhne
  • Hydrolases, Nucleic Acids Encoding Them And Methods For Making And Using Them
    Publication number: 20070202566
    Abstract: The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phosphlipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzyme, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds).
    Type: Application
    Filed: March 8, 2004
    Publication date: August 30, 2007
    Inventors: Uwe Bornscheuer, David Weiner, Tim Hitchman, Jonathan Lyon, Sirirung Wongsakul
  • Recombinant porcine liver esterases, their use and a method for the production thereof
    Patent number: 7229817
    Abstract: The invention relates to biotechnologically expressible, enzymically active recombinant porcine liver esterases, to a biotechnological method for the preparation thereof and to the use thereof in organic synthesis. The monomeric subunits of recombinant porcine liver esterase are truncated at their C-terminal end, compared with naturally occurring porcine liver esterase subunits. Moreover, it has proved to be an additional advantage to truncate the N-terminal end as well.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: June 12, 2007
    Assignee: Degussa AG
    Inventors: Uwe Bornscheuer, Anna Musidlowska, Claudia Schmidt-Dannert, Stefan Lange
  • Process for the enzymatic synthesis of ethers
    Publication number: 20070059789
    Abstract: An enzymatic process for preparing ethers is disclosed which includes reacting one or more alcohols with an ether in the presence of at least one enzyme.
    Type: Application
    Filed: September 11, 2006
    Publication date: March 15, 2007
    Applicant: Goldschmidt GmbH
    Inventors: Uwe Bornscheuer, Burghard Gruning, Geoffrcy Hills, Patrick Mobius, Oliver Thum, Christian Weitemeyer
  • Hydrolase enzymes and their use in kinetic resolution
    Publication number: 20050123991
    Abstract: The invention relates to hydrolases and to polynucleotides encoding the hydrolases. In addition, the invention relates to the use of these hydrolase enzymes in kinetic resolution.
    Type: Application
    Filed: February 2, 2005
    Publication date: June 9, 2005
    Inventors: Jay Short, Eric Mathur, Markus Baumann, Uwe Bornscheuer
  • EPOTHILONE SYNTHESIS BUILDING BLOCKS III AND IV: ASYMMETRICALLY SUBSTITUTED ACYLOINS AND ACYLOIN DERIVATIVES, METHODS FOR THEIR PRODUCTION AND METHODS FOR THE PRODUCTION OF EPOTHILONES B, D AND EPOTHILONE DERIVATIVES
    Patent number: 6867333
    Abstract: The present invention is directed to novel acyloins, their derivatives, methods for their production and their use for the production of novel epothilones and their derivatives. In addition, the invention is directed to the building blocks for epothilone synthesis, methods for their production and the use of synthetic building blocks for the production of epothilones and their derivatives.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: March 15, 2005
    Assignee: Morphochem AG
    Inventors: Ludger A. Wessjohann, Gunther Scheid, Uwe Bornscheuer, Erik Henke, Wouter Kuit, Romano Orru
  • Epothilone synthesis building blocks III and IV: asymmetrically substituted acyloins and acyloin derivatives, methods for their production and methods for the production of epothilones B, D and epothilone derivatives
    Publication number: 20040082651
    Abstract: The present invention is directed to novel acyloins, their derivatives, methods for their production and their use for the production of novel epothilones and their derivatives. In addition, the invention is directed to the building blocks for epothilone synthesis, methods for their production and the use of synthetic building blocks for the production of epothilones and their derivatives.
    Type: Application
    Filed: April 15, 2003
    Publication date: April 29, 2004
    Inventors: Ludger A. Wessjohann, Gunther Scheid, Uwe Bornscheuer, Erik Henke, Wouter Kuit, Romano Orru
  • Process for the preparation of L-menthol
    Patent number: 6706500
    Abstract: L-Menthol is prepared from D,L-menthyl derivatives by enantioselective enzymatic cleavage.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: March 16, 2004
    Assignee: Symrise GmbH & Co. KG
    Inventors: Ian-Lucas Gatfield, Jens-Michael Hilmer, Uwe Bornscheuer, Rolf Schmidt, Sandra Vorlová
  • Alcohol dehydrogenase and use thereof
    Publication number: 20030171544
    Abstract: The invention relates to a novel alcohol dehydrogenase (ADHF1) from Pseudomonas fluorescens (DSM 50106) and to functional variants thereof and to a process for selective reduction of ketones to the corresponding alcohols by using such alcohol dehydrogenases.
    Type: Application
    Filed: March 13, 2002
    Publication date: September 11, 2003
    Applicant: DEGUSSA AG
    Inventors: Thomas Riermeier, Uwe Bornscheuer, Josef Altenbuchner, Petra Hildebrandt
  • Process for the preparation of L-menthol
    Publication number: 20020182674
    Abstract: L-Menthol is prepared from D,L-menthyl derivatives by enantioselective enzymatic cleavage.
    Type: Application
    Filed: January 7, 2002
    Publication date: December 5, 2002
    Inventors: Ian-Lucas Gatfield, Jens-Michael Hilmer, Uwe Bornscheuer, Rolf Schmidt, Sandra Vorlova
  • Process for preparation to stereoisomeric carboxylic acid esters
    Patent number: 6365398
    Abstract: The present invention relates to a process for the preparation of stereoisomeric carboxylic acid esters consisting of an acid and of an alcohol component each having at least one chiral center, at least one stereoisomer of the carboxylic acid ester being present in an excess, by reacting a racemic carboxylic acid ester with a racemic alcohol in the presence of a carboxyl ester hydrolase (EC 3.1.1).
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: April 2, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Uwe Bornscheuer, Erik Henke, Hong Yang
  • ALTERATION OF THE SUBSTRATE SPECIFICITY OF ENZYMES
    Publication number: 20020034776
    Abstract: A method for altering the substrate specificity of enzymes is described.
    Type: Application
    Filed: September 28, 1998
    Publication date: March 21, 2002
    Inventors: UWE BORNSCHEUER, HARTMUT HERMANN MEYER, JOSEF ALTENBUCHNER
  • Process for the resolution of esters of arylalkylcarboxylic acids
    Patent number: 6201147
    Abstract: The invention relates to a process for the resolution of esters of arylalkylcarboxylic acids of the general formula which comprises reacting compounds of the general formula I with an alcohol of the general formula R6—OH in the presence of a lipase or esterase to give compounds of the general formulae Ia and II at least one of the compounds of the formulae Ia and II being present in an enantiomeric excess and the substituents and variables in the formulae I, Ia and II are as defined in the specification.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: March 13, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Uwe Bornscheuer, Erik Henke, Yang Hong