Patents by Inventor Uwe D. Treuner

Uwe D. Treuner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenylglycine derivatives useful as serine protease inhibitors
    Patent number: 7122559
    Abstract: Compounds having the formula (I), or a stereoisomer or pharmaceutically-acceptable salt, or hydrate thereof, are useful as factor VIIa inhibitors, wherein X is —NR6S(O)pR16; W is hydrogen or —(CR7R8)q—W1; W1 is hydrogen or a bond with R6; Z is a 5-membered heteroaryl group, a five to six membered heterocyclo or cycloalkyl group, a 9 to 10 membered bicyclic aryl or heteroaryl, or a six membered aryl or heteroaryl, and R1, R2, R3, R6, R7, and R16 are as defined in the specification.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: October 17, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter W. Glunz, Gregory S. Bisacchi, George C. Morton, Alexandra A. Holubec, E. Scott Priestley, Xiaojun Zhang, Uwe D. Treuner
  • Phenylglycine derivatives useful as serine protease inhibitors
    Publication number: 20040204412
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: February 10, 2004
    Publication date: October 14, 2004
    Inventors: Peter W. Glunz, Gregory S. Bisacchi, George C. Morton, Alexandra A. Holubec, E. Scott Priestley, Xiaojun Zhang, Uwe D. Treuner
  • Acid derivatives useful as serine protease inhibitors
    Patent number: 6642252
    Abstract: Compounds having the formula (I), are useful as serine protease inhibitors, more particularly inhibitors of Factors VIIa, IXa, Xa, and/or XIa, wherein ring B is phenyl or pyridyl, W is preferably C(═O)NR4R5, L is a linker group, X2 comprises nitrogen or carbon, Z is an optionally-substituted monocyclic or bicyclic ring system, and R1, R2, R3, R4, R5 and R6 are as defined in the specification.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: November 4, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory S. Bisacchi, James C. Sutton, William A. Slusarchyk, Uwe D. Treuner, Guohua Zhao, Daniel L. Cheney, Yan Shi, Shung C. Wu
  • Acid derivatives useful as serine protease inhibitors
    Publication number: 20030166685
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: November 7, 2001
    Publication date: September 4, 2003
    Inventors: Gregory S. Bisacchi, James C. Sutton, William A. Slusarchyk, Uwe D. Treuner, Guohua Zhao, Daniel L. Cheney, Yan Shi, Shung C. Wu
  • Hereroaryl derivatives of monocyclic beta-lactam antibiotics
    Patent number: 5705645
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: January 6, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Joseph E. Sundeen, Henner Straub, Peter Ermann, Uwe D. Treuner, Kent Amsberry, Michael Fakes, Sailesh A. Varia
  • Intermediates for the preparation of heteroaryl derivatives of monocyclic beta-lactam antiobiotics
    Patent number: 5420277
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring. Also described are various intermediates for the preparation of compounds of formula 1.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: May 30, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Joseph E. Sundeen, Henner Straub, Peter Ermann, Uwe D. Treuner, Kent Amsberry, Michael Fakes, Sailesh A. Varia
  • Heteroaryl derivatives of monocyclic beta-lactam antibiotics
    Patent number: 5290929
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: March 1, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Joseph E. Sundeen, Henner Straub, Peter Ermann, Uwe D. Treuner, Kent Amsberry, Michael Fakes, Sailesh A. Varia
  • Substituted pyran derivatives having antiinfective activity
    Patent number: 5266593
    Abstract: Novel antibiotic substances, having the general formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as defined herein.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: November 30, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter Ermann, Henner Straub, Uwe D. Treuner, Jakob-Matthias Drossard
  • Aminoalkylphosphonic acid esters of natural 4-methoxy-5-methyl-pyran-3-ol and derivatives thereof
    Patent number: 5248790
    Abstract: Antibiotic substances having the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: September 28, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • Monobactam hydrazide derivatives
    Patent number: 5112968
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof which possess antibacterial activity.R.sub.s is a substituted hydroxy pyridone of the formulae: ##STR2## wherein Y.sub.1 is CH.sub.2 X; COOR.sub.6 ; CONR.sub.7 R.sub.8 ; OH; OCH.sub.2 R.sub.9 ; CHF.sub.2 ; CHO; CH.dbd.N--OR.sub.10 ; CH.dbd.CH--R.sub.11 ; CN; CH.dbd.N--NHR.sub.12, and Y.sub.2 is hydrogen; COOH; CONH.sub.2 ; CN; CSNH.sub.2 ; COO lower alkyl; CONR.sub.7 /R.sub.8.
    Type: Grant
    Filed: July 28, 1989
    Date of Patent: May 12, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • Certain (2-carboxy or 2-propenoic or 2-carbonyl)-3-halo-4,5-dioxy pyridine intermediates and the corresponding 1,4-dihydro-4-pyridones)
    Patent number: 5068331
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, exhibit antibacterial activity wherein R is ##STR2##
    Type: Grant
    Filed: July 13, 1990
    Date of Patent: November 26, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • 2-oxo-[[(substituted sulfonyl)-amino]carbonyl]-azetidines
    Patent number: 4959470
    Abstract: Componds having the formula ##STR1## and pharmaceutically acceptable salts thereof, exhibit antibacterial activity wherein R is ##STR2##
    Type: Grant
    Filed: August 17, 1988
    Date of Patent: September 25, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • 2-oxo-1-(((substituted sulfonyl)amino)-carbonyl)azetidines
    Patent number: 4801705
    Abstract: Antibacterial activity is exhibited by .beta.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: January 31, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Jakob-Matthias Drossard, Peter H. Ermann, Henner Straub, Uwe D. Treuner
  • 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
    Patent number: 4762922
    Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and having an activating group in the 1-position of the formula ##STR1## wherein R is ##STR2## A.sub.1 is --NH-- or ##STR3## A.sub.2 is ##STR4## or --CH.dbd.CH--.
    Type: Grant
    Filed: July 1, 1987
    Date of Patent: August 9, 1988
    Assignee: Squibb Corporation
    Inventors: Hermann Breuer, Uwe D. Treuner
  • 2-oxo-1-[[(substituted sulfonyl)amino]carbonyl]azetidines
    Patent number: 4743685
    Abstract: Antibacterial activity is exhibited by 2-azetidinones having a 3-acylamino substituent and having an activating group in the 1-position of the formula ##STR1##
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: May 10, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Uwe D. Treuner, William H. Koster, Robert Zahler
  • 4-amino derivatives of 2-oxo-1-azetidinesulfonic acid salts
    Patent number: 4734496
    Abstract: .beta.-Lactams having a sulfonic acid salt substituent in the 1-position, an acylamino substituent in the 3-position and an --NR.sub.2 R.sub.3 substituent in the 4-position wherein R.sub.2 and R.sub.3 are the same or different and each is ##STR1## or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached are ##STR2## R.sub.4 is alkyl, aryl or arylalkyl; and R.sub.5 and R.sub.6 are the same or different and each is hydrogen, halogen, alkyl, alkoxy, alkylthio, alkoxycarbonyl, carboxyl or a carboxyl salt; have antibacterial activity.
    Type: Grant
    Filed: May 29, 1981
    Date of Patent: March 29, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Treuner, Theodor Denzel, Hermann Breuer
  • Hydrazide containing derivatives of 2-amino-4-thiazole-acetic acid
    Patent number: 4680409
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen or alkyl of 1 to 4 carbon atoms, or R.sub.1 and R.sub.2 together with the carbon atom to which they are attached form a cycloalkyl ring;R.sub.3 is hydrogen or alkyl;R.sub.4 is hydrogen or alkyl, and R.sub.5 is hydrogen, alkyl, phenyl, substituted phenyl, a 4,5,6 or 7-membered heterocycle, phenylalkyl, (substituted phenyl)alkyl, (4,5,6 or 7-membered heterocycle)alkyl, ##STR2## or together R.sub.4 and R.sub.5 are .dbd.CH--Y.sub.7 ; wherein Y.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, methylcarbonyl, trifluoromethylcarbonyl, phenylcarbonyl, (substituted phenyl)carbonyl, carboxymethyl, methylsulfonyl, phenylsulfonyl, (substituted phenyl)sulfonyl, aminocarbonyl, aminocarbonylamino, aminoethyl, hydroxy, alkoxy, amino, alkylamino, dialkylamino, phenylcarbonylamino, (substituted phenyl)carbonylamino, 1-pyrrolidinyl or 1-piperidinyl; Y.sub.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: July 14, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines
    Patent number: 4587047
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5,6 or 7-membered heterocycle (R.sub.c), phenylalkyl, (substituted phenyl)alkyl, R.sub.c -alkyl or --NR.sub.a R.sub.b wherein R.sub.a and R.sub.b are the same or different and each is hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl, or (substituted phenyl)alkyl or one of R.sub.a and R.sub.b is hydrogen, alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl and the other is amino, alkanoylamino, arylcarbonylamino, alkoxycarbonylamino, alkylsulfonylamino, alkylamino, dialkylamino, phenylamino, (substituted phenyl)amino, hydroxy, cyano, alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, (substituted phenyl)alkoxy, R.sub.c, R.sub.c -alkyl, R.sub.
    Type: Grant
    Filed: April 1, 1982
    Date of Patent: May 6, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, William A. Slusarchyk, Theodor Denzel, Uwe D. Treuner
  • 4-(3-Acylamino-2-oxo-1-azetidinyl)-4-oxo-2-butenoic acid
    Patent number: 4551277
    Abstract: Antibacterial activity is exhibited by (3-acylamino)-2-azetidinones having in the 1-position a group of the formula ##STR1## or a salt or ester thereof wherein R.sub.5 and R.sub.6 are the same or different and each is hydrogen or alkyl.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: November 5, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • 3-Acylamino-2-oxoazetidine-1-(.beta.-oxopropionic acid)
    Patent number: 4534896
    Abstract: Antibacterial activity and .beta.-lactamase inhibitory activity is exhibited by .beta.-lactams having a 3-acylamino substituent and in the 1-position a group having the formula ##STR1## wherein R.sub.5 is hydrogen, methyl or ethyl.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: August 13, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Treuner, Hermann Breuer