Patents by Inventor Uwe Gerlach

Uwe Gerlach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of inhibitors of the KQTI channel and methods of controlling and treating diseases caused by helminths and ectoparasites
    Patent number: 6335363
    Abstract: Use of inhibitors of the KQT1 channel for preparing a medicament for treating diseases caused by helminths and ectoparasites Inhibitors of the KQT1 channel are a novel way of destroying helminths and ectoparasites. For this reason, blockers of the cellular KQT1 channel, which is present in helminths and ectoparasites, are used for preparing a medicament for the treatment of vertebrates and humans infested by helminths or ectoparasites. These KQT1 blockers are used as medicaments on their own or in combination with other medicaments and therapeutic measures. Inhibitors of the KQT1 channel are likewise a novel mechanism of action for phytoparasites such as insects, arachnids, molluscs and nematodes, and consequently, they are used for preparing a crop protection composition.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: January 1, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Uwe Gerlach, Joachim Hofmann, Hans Jochen Lang, Aguan Wei
  • Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them
    Patent number: 6333349
    Abstract: The present invention relates to compounds of formula I, in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in pharmaceuticals. The compounds effect the potassium channel or the IKs channel opened by cyclic adenosine monophosphate (cAMP) and are outstandingly suitable as pharmaceutical active compounds, for example for the prophylaxis and therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal disorders.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: December 25, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Joachim Brendel, Hans Jochen Lang, Uwe Gerlach
  • Indanyl-substituted benzenecarboxamides, processes for their preparation, their use as a medicament, and pharmaceutical formulations containing them
    Patent number: 6221866
    Abstract: in which R(1) to R(8) have the meanings stated in the claims, act on the Kv1.5 potassium channel, and inhibit a potassium current, referred to as “ultra-rapidly activating delayed rectifier,” in the human atrium. They are therefore very particularly suitable as novel antiarrhythmic active substances, in particular for the treatment and prophylaxis of atrial arrhythmias, e.g., atrial fibrillation or atrial flutter.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: April 24, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Joachim Brendel, Uwe Gerlach, Hans Ulrich Stilz, Hans-Jochen Lang
  • Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    Patent number: 6191164
    Abstract: Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them Chromans of the formula I and of the formula 1a having the meanings R(A), R(B), R(C) and R(1) to R(8) indicated in the claims are outstandingly suitable for preparing a medicament for blocking the K+ channel which is opened by cyclic adenosine monophosphate (cAMP); and further for preparing a medicament for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and of the intestinal region, in particular of the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal illnesses, for the treatment and prevention of all types of arrhythmias including ventricular and supraventricular arrhythmias, and for the control of reentry arrhythmias and for the prevention of sudden heart death as a result of ventricular fibrillation.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: February 20, 2001
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans Jochen Lang, Uwe Gerlach, Joachim Brendel, Henrich Christian Englert, Heinz Gögelein, Max Hropot, Helmut Bohn, Andreas Herling, Andreas Busch, Rainer Greger
  • Sulfonamide-substituted compounds, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
    Patent number: 6184221
    Abstract: Compounds of the formula I having the meanings of the substituents indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal illnesses.
    Type: Grant
    Filed: August 4, 1998
    Date of Patent: February 6, 2001
    Assignee: Hoechst Marion Roussel Deutschland GmbH
    Inventors: Uwe Gerlach, Hans Jochen Lang, Klaus Weidmann, Joachim Brendel
  • Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparations comprising them
    Patent number: 6177449
    Abstract: Compounds of the formula I having the meanings of the substituents indicated in the claims are outstandingly efficacious substances for producing medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal disorders.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: January 23, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Joachim Brendel, Uwe Gerlach, Hans Jochen Lang, Klaus Weidmann
  • Sulfonamide-substituted compounds, process for their preparation, their use as a medicament or diagnostic, and a medicament comprising them
    Patent number: 6087399
    Abstract: Compounds of formula I ##STR1## in which R(1) to R(8) and X have the meanings indicated in the specification, are useful for the production of medicaments having K.sup.+ channel-blocking action; in particular for the production of a medicament for the treatment or prophylaxis of stimulated gastric acid secretion; of ulcers of the stomach and of the intestinal region; of reflux esophagitis; of diarrhea; of all types of arrhythmias, including ventricular and supraventricular arrhythmias; and of reentry arrhythmias and for the prophylaxis of sudden heart death as a result of ventricular fibrillation.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: July 11, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Uwe Gerlach, Joachim Brendel, Hans Jochen Lang, Klaus Weidmann
  • Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
    Patent number: 6071953
    Abstract: Chromans of formula I ##STR1## with the meanings of R(A), R(B) and R(1) to R(8) stated in the specification are suitable for producing a medicament for blocking the K.sup.+ channel that is opened by cyclic adenosine monophosphate (cAMP); also for producing medicaments for inhibiting gastric acid secretion; for the treatment of ulcers of the stomach and the intestinal region, in particular the duodenum, for the treatment of reflux esophagitis, for the treatment of diarrheal disorders, for the treatment and prevention of all types of arrhythmias, including atrial, ventricular and supraventricular arrhythmias, for controlling reentry arrhythmias and for preventing sudden heart death as a result of ventricular fibrillation.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: June 6, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hans Jochen Lang, Joachim Brendel, Uwe Gerlach, Klaus Weidmann
  • Sulfonamide-substituted fused 5-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them
    Patent number: 6015822
    Abstract: Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastro-intestinal region or for the treatment of diarrheal illnesses.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: January 18, 2000
    Assignee: Hoechst Marion Roussel Deutschland GmbH
    Inventors: Joachim Brendel, Uwe Gerlach, Hans Jochen Lang, Klaus Weidmann
  • Sulfonamide-substituted benzopyran derivatives, processes for their preparation, their use as a medicament, and pharmaceutical preparations comprising them
    Patent number: 6008245
    Abstract: Sulfonamide-substituted benzopyran derivatives, processes for their preparation, their use as a medicament, and pharmaceutical preparations comprising them Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal diseases.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: December 28, 1999
    Assignee: Hoechst Marion Roussel Deutschland GmbH
    Inventors: Joachim Brendel, Uwe Gerlach, Hans Jochen Lang, Klaus Weidmann
  • Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them
    Patent number: 5977177
    Abstract: This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them.Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit effects on the cardiovascular system.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinrich Englert, Uwe Gerlach, Dieter Mania, Heinz Gogelein, Joachim Kaiser
  • Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparations comprising them
    Patent number: 5955607
    Abstract: Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly efficacious substances for producing medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular arrhythmias, for the treatment of ulcers of the gastrointestinal region or for the treatment of diarrheal disorders.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: September 21, 1999
    Assignee: Hoechst Marion Roussel Deutschland
    Inventors: Joachim Brendel, Uwe Gerlach, Hans Jochen Lang, Klaus Weidmann
  • Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them
    Patent number: 5880155
    Abstract: This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them.Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit effects on the cardiovascular system.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: March 9, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinrich Englert, Uwe Gerlach, Dieter Mania, Heinz Gogelein, Joachim Kaiser
  • Sulfonamide-substituted compounds, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparation comprising them
    Patent number: 5856338
    Abstract: Compounds of formula I ##STR1## having the meanings indicated in the claims are outstandingly active substances for the production of medicaments for the prophylaxis and therapy of cardiovascular disorders, in particular arrhythmias; for the treatment of ulcers of the gastrointestinal region; or for the treatment of diarrheal illnesses.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: January 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Joachim Brendel, Hans Jochen Lang, Uwe Gerlach, Klaus Weidmann
  • 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them
    Patent number: 5849755
    Abstract: 3-amidochromanylsulfonyl(thio)ureas of the formula (I): ##STR1## which are valuable pharmaceutically active compounds for the treatment of disturbances of the cardiovascular system, in particular for the treatment of arrhythmias, for preventing sudden cardiac death or for influencing a reduced contractility of the heart, and processes for their preparation, their use and pharmaceutical preparations comprising them.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: December 15, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinrich Christian Englert, Uwe Gerlach, Dieter Mania, Wolfgang Linz, Heinz Gogelein, Erik Klaus
  • Substituted chromanysulfonyl (thio) ureas, processing for their preparation and pharmaceutical uses thereof
    Patent number: 5811448
    Abstract: Substituted chromanylsulfonyl(thio)ureas, processes for their preparation, their use in pharmaceutical preparations, and pharmaceutical preparations comprising themChromanylsulfonyl(thio)ureas of the formula I ##STR1## are useful pharmaceuticals for the treatment of cardiac arrhythmias and for the prevention of sudden heart death due to arrhythmia. They can be used as antiarrhythmics and are suitable for the prevention of sudden heart death, for the treatment of cardiac insufficiency and also heart failure as a result of the effects of shock.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: September 22, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinrich Christian Englert, Uwe Gerlach, Dieter Mania, Wolfgang Linz, Heinz Gogelein, Erik Klaus, Peter Crause
  • Substituted benzenesulfonylureas and -thioureas, preparation processes and possible uses of pharmaceutical preparations based on these compounds
    Patent number: 5731341
    Abstract: Described herein are substituted benzenesulfonylureas and -thioureas of the formula (I): ##STR1## useful in treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrythmia. The compounds of formula (I) can be used as antiarrythmics and are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: March 24, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinrich Englert, Dieter Mania, Jens Hartung, Heinz Gogelein, Joachim Kaiser, Uwe Gerlach
  • Substituted benzenesulfonylureas and-thioureas, processes for their preparation, their use as a medicament or diagnostic, and medicament containing them
    Patent number: 5652268
    Abstract: This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation, their use as a medicament or diagnostic, and medicament containing them.Substituted benzenesulfonylureas and -thioureas 1 ##STR1## exhibit effects on the cardiovascular system.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: July 29, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinrich Englert, Uwe Gerlach, Dieter Mania, Heinz Gogelein, Joachim Kaiser
  • Process for the preparation of cephem prodrug esters
    Patent number: 5637721
    Abstract: The invention relates to a process which comprises a compound of the formula II ##STR1##
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 10, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Elisabeth Defossa, Gerd Fischer, Uwe Gerlach, Rolf Horlein, Norbert Krass, Rudolf Lattrell, Ulrich Stache, Theodor Wollmann
  • Substituted benzenesulfonylureas and -thioureas, processes for their preparation, their use for the production of pharmaceutical preparations, and medicaments containing them
    Patent number: 5633239
    Abstract: Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit outstanding effects on the cardiovascular system.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: May 27, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinrich Englert, Uwe Gerlach, Dieter Mania, Heinz G ogelein, Joachim Kaiser