Patents by Inventor Uwe Grether

Uwe Grether has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
    Patent number: 12180196
    Abstract: The invention relates to a compound of formula (I) wherein A1 and R1-R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: December 31, 2024
    Assignees: HOFFMANN-LA ROCHE INC., EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
    Inventors: Simon M. Ametamey, Luca Gobbi, Uwe Grether, Julian Kretz
  • NOVEL PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2
    Publication number: 20240383872
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2, X and R1—R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Application
    Filed: July 26, 2024
    Publication date: November 21, 2024
    Inventors: Luca Gobbi, Uwe Grether, Julian Kretz, Simon M. Ametamey
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20240383904
    Abstract: The invention provides new MAGL inhibitors having the general formula (I) wherein the variables are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: April 11, 2024
    Publication date: November 21, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Machoud AMOUSSA, Joerg BENZ, Julie Elisabeth Francoise BLAISING, Maude GIROUD, Uwe GRETHER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn Susannah O’HARA, Bernd PUELLMANN, Martin RITTER, Didier ROMBACH, Philipp Claudio SCHMID, Matthias Beat WITTWER
  • RADIOLABELED CANNABINOID RECEPTOR 2 LIGAND
    Publication number: 20240308974
    Abstract: The present invention relates to a compound of formula (I) wherein R1, R2, and R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a radiolabeled ligand.
    Type: Application
    Filed: May 21, 2024
    Publication date: September 19, 2024
    Inventors: Simon M. Ametamey, Luca Gobbi, Uwe Grether, Julian Kretz, Dieter Muri, Ahmed Haider Wahauib
  • SYNTHESIS OF [1,2,3]TRIAZOLO[4,5-D]PYRIMIDINES
    Publication number: 20240287084
    Abstract: The present invention relates to a process for the preparation of [1,2,3]triazolo[4,5-d]pyrimidine derivatives useful as pharmaceutically active compounds, in particular 1-[5-tert-butyl-3-[(1-methyltetrazol-5-yl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol.
    Type: Application
    Filed: April 24, 2024
    Publication date: August 29, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jean-Michel Adam, Uwe Grether, Christian Moessner, Paolo Tosatti
  • Pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2
    Patent number: 12071420
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2, X and R1-R3 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: August 27, 2024
    Assignees: HOFFMANN-LA ROCHE INC., ETH ZUERICH
    Inventors: Luca Gobbi, Uwe Grether, Julian Kretz, Simon M. Ametamey
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20240199587
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, X, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: October 20, 2023
    Publication date: June 20, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Machoud AMOUSSA, Joerg BENZ, Niels Kevin BRIAN, Kallie FRISTON, Maude GIROUD, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Camiel John LEAKE, Rainer E. MARTIN, David Friedrich Erhard NIPPA, Fionn Susannah O’HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER, Didier ROMBACH, Philipp Claudio SCHMID, Shounan ZHANG
  • Radiolabeled cannabinoid receptor 2 ligand
    Patent number: 11999710
    Abstract: The present invention relates to a compound of formula (I) wherein R1, R2, and R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a radiolabeled ligand.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: June 4, 2024
    Assignees: HOFFMANN-LA ROCHE INC., ETH ZUERICH
    Inventors: Simon M. Ametamey, Luca Gobbi, Uwe Grether, Julian Kretz, Dieter Muri, Ahmed Haider Wahauib
  • Heterocyclic compounds
    Patent number: 11981661
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein B, C, L, X, Y, RL and R3 to R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: May 14, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
  • HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20240150373
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: September 26, 2023
    Publication date: May 9, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Marius Daniel Rinaldo LUTZ, Fionn O'HARA, Hans RICHTER, Martin RITTER, Didier ROMBACH, Martin KURATLI
  • Heterocyclic compounds
    Patent number: 11814375
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L1, X, m, n, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: November 14, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joerg Benz, Luca Gobbi, Uwe Grether, Katrin Groebke Zbinden, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
  • Heterocyclic compounds as monoacylglycerol lipase inhibitors
    Patent number: 11802133
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: October 31, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Charles Bell, Joerg Benz, Luca Gobbi, Uwe Grether, Katrin Groebke Zbinden, Benoit Hornsperger, Buelent Kocer, Carsten Kroll, Bernd Kuhn, Marius Daniel Rinaldo Lutz, Fionn O'Hara, Hans Richter, Martin Ritter, Didier Rombach, Martin Kuratli
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20230203056
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein X, Y, Z, A, L, B, and R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: February 22, 2023
    Publication date: June 29, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O'HARA, Hans RICHTER, Martin RITTER, Philipp SCHMID
  • BEZOXAZINE DERIVATIVES USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20230183224
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1, R2 and R3 are as described herein, pharmaceutically acceptable salts thereof, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: November 22, 2022
    Publication date: June 15, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Charles BELL, Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Buelent KOCER, Bernd KUHN, Hans RICHTER, Satoshi TSUCHIYA
  • Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists
    Patent number: 11655243
    Abstract: The invention relates to a compound of formula (I) wherein A1, A2 and R1-R5 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: May 23, 2023
    Assignees: HOFFMANN-LA ROCHE INC., EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
    Inventors: Simon M. Ametamey, Kenneth Atz, Luca Gobbi, Uwe Grether, Wolfgang Guba, Julian Kretz
  • OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS
    Publication number: 20230117324
    Abstract: The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R20 to R23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: August 9, 2022
    Publication date: April 20, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Dennis Jul HANSEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Fionn O'HARA, Hans RICHTER, Martin RITTER, Satoshi TSUCHIYA, Rui CHEN
  • Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors
    Patent number: 11608347
    Abstract: The invention provides new heterocyclic compounds having the general formula (Ie) wherein R1, R1a and R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: March 21, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ann Petersen, Joerg Benz, Uwe Grether, Benoit Hornsperger, Buelent Kocer, Bernd Kuhn, Hans Richter, Satoshi Tsuchiya, Yangcheng Qiu, Rui Chen
  • HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20230050901
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: May 20, 2022
    Publication date: February 16, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Marius Daniel Rinaldo LUTZ, Fionn O'HARA, Hans RICHTER, Martin RITTER, Didier ROMBACH, Martin KURATLI
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220275005
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: May 5, 2022
    Publication date: September 1, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Marius Daniel Rinaldo LUTZ, Fionn O`HARA, Hans RICHTER
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220267349
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, Q, U, V, W, X, Z, m, n, and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: January 31, 2022
    Publication date: August 25, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Luca GOBBI, Uwe GRETHER, Steven Paul HANLON, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Martin KURATLI, Guofu LIU, Fionn O`HARA, Hans RICHTER, Martin RITTER