Patents by Inventor Uwe Joerg Ries

Uwe Joerg Ries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoselective process
    Patent number: 10189776
    Abstract: The invention relates to a method for the stereoselective preparation of compounds of formula (IV).
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: January 29, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Joerg Ries, Nizar Haddad, Bo Qu
  • STEREOSELECTIVE PROCESS
    Publication number: 20180258031
    Abstract: The invention relates to a method for the stereoselective preparation of compounds of formula (IV).
    Type: Application
    Filed: September 16, 2016
    Publication date: September 13, 2018
    Inventors: Uwe Joerg Ries, Nizar HADDAD, Bo QU
  • Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Patent number: 9670166
    Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: June 6, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Gnamm, Thorsten Oost, Stefan Peters, Holger Hoesch, Uwe Joerg Ries
  • Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Patent number: 9657015
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: May 23, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Gnamm, Ralf Anderskewitz, Holger Hoesch, Gerd Morschhaeuser, Thorsten Oost, Stefan Peters, Uwe Joerg Ries
  • SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
    Publication number: 20160340319
    Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
    Type: Application
    Filed: August 5, 2016
    Publication date: November 24, 2016
    Inventors: Christian GNAMM, Thorsten OOST, Stefan PETERS, Holger HOESCH, Uwe Joerg RIES
  • Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Patent number: 9475779
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: October 25, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Ralf Anderskewitz, Christian Gnamm, Holger Hoesch, Gerd Morschhaeuser, Stefan Peters, Uwe Joerg Ries
  • Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Patent number: 9458113
    Abstract: Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: October 4, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Ralf Anderskewitz, Christian Gnamm, Holger Hoesch, Gerd Morschhaeuser, Thorsten Oost, Uwe Joerg Ries
  • Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Patent number: 9440930
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: September 13, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Ralf Anderskewitz, Christian Gnamm, Gerd Morschhaeuser, Stefan Peters, Uwe Joerg Ries
  • Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
    Patent number: 9290459
    Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: March 22, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christian Gnamm, Thorsten Oost, Stefan Peters, Holger Hoesch, Uwe Joerg Ries
  • SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
    Publication number: 20160039812
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 11, 2016
    Inventors: Christian GNAMM, Ralf ANDERSKEWITZ, Holger HOESCH, Gerd MORSCHHAEUSER, Thorsten OOST, Stefan PETERS, Uwe Joerg RIES
  • SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
    Publication number: 20160031830
    Abstract: Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Inventors: Stefan PETERS, Ralf ANDERSKEWITZ, Christian GNAMM, Holger HOESCH, Gerd MORSCHHAEUSER, Thorsten OOST, Uwe Joerg RIES
  • SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
    Publication number: 20160031829
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Inventors: Thorsten OOST, Ralf ANDERSKEWITZ, Christian GNAMM, Holger HOESCH, Gerd MORSCHHAEUSER, Stefan PETERS, Uwe Joerg RIES
  • SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
    Publication number: 20160031831
    Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity.
    Type: Application
    Filed: July 27, 2015
    Publication date: February 4, 2016
    Inventors: Thorsten OOST, Ralf ANDERSKEWITZ, Christian GNAMM, Gerd MORSCHHAEUSER, Stefan PETERS, Uwe Joerg RIES
  • Crystalline ethyl 4-[4-[(2R)-3-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-1-oxo-2-[[[4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-1-piperidinyl]carbonyl]oxy]propyl]-1-piperazinyl]-piperidine-1-acetate difumarate
    Patent number: 8551987
    Abstract: The invention relates to the novel salts AB of the base A with a physiologically acceptable acid B which is selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, fumaric acid and salicylic acid and the polymorphic compounds, the corresponding solvates and hydrates thereof.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: October 8, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Kathrin Pachur, Uwe Joerg Ries, Ulrike Werthmann, Sonja Sproll
  • Preparation process
    Patent number: 8222402
    Abstract: A process for preparing compounds of the formula (I) in which R1.1, R1.2, R1.3 and R2 are as defined in the description.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: July 17, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Kathrin Pachur, Stefan Goepper, Guenther Huchler, Michael Konrad, Kathrin Maier, Werner Rall, Uwe Joerg Ries, Andreas Zopf
  • NOVEL COMPOUNDS
    Publication number: 20120058994
    Abstract: The invention relates to the novel salts AB of the base A with a physiologically acceptable acid B which is selected from the group consisting of hydrochloric acid, hydrobromic acid, sulfuric acid, fumaric acid and silcylic acid and the polymorphic compounds, the corresponding solvates and hydrates thereof.
    Type: Application
    Filed: September 25, 2008
    Publication date: March 8, 2012
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Kathrin Pachur, Uwe Joerg Ries, Ulrike Werthmann, Sonja Sproll
  • NOVEL PREPARATION PROCESS
    Publication number: 20110071286
    Abstract: A process for preparing compounds of the formula (I) in which R1.1, R1.2, R1.3 and R2 are as defined in the description.
    Type: Application
    Filed: August 12, 2008
    Publication date: March 24, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Kathrin Pachur, Stefan Goepper, Guenther Huchler, Michael Konrad, Kathrin Maier, Werner Rall, Uwe Joerg Ries, Andreas Zopf
  • Carboxylic acid amides having antithrombotic activity
    Publication number: 20020151595
    Abstract: Compounds with antithrombotic activity and factor Xa-inhibiting activity of the general formula: 1
    Type: Application
    Filed: January 17, 2002
    Publication date: October 17, 2002
    Inventors: Uwe Joerg Ries, Henning Priepke, Herbert Nar, Jean-Marie Stassen, Wolfgang Wienen
  • Antithrombotic compounds
    Publication number: 20020151534
    Abstract: Antithrombotic compounds of general formula 1
    Type: Application
    Filed: January 16, 2002
    Publication date: October 17, 2002
    Inventors: Uwe Joerg Ries, Henning Priepke, Herbert Nar, Jean-Marie Stassen, Wolfgang Wienen