Abstract: The invention provides an item of clothing in the form of trousers (1) for use outdoors and/or in hunting, having two trouser legs (2, 3) and a device for protecting against pests. To provide effective protection against pests, the device an internal insert (4), preventing the passage of pests, in particular ticks, is provided in at least one trouser leg (2,3), the lower end (5) of which insert reaches as far as the foot area (6) of the user and the upper end (8) of which insert reaches as far as the foot area (6) of the user and the upper end (8) of which is permanently connected or can be detachably connected to the trouser leg (2,3) on the inside, wherein the connection at the upper end (8) is closed circumferentially to prevent passage of the pest through connection (9).

Abstract: The invention relates to an item of clothing in the form of trousers (1) for use outdoors and/or in hunting, having two trouser legs (2, 3) and a device for protecting against pests. In order to provide effective protection against pests, as a device for protection against pests, an internal insert (4) preventing the passage of pests, in particular ticks, is provided in at least one trouser leg (2,3), the lower end (5) of which insert reaches as far as the foot area (6) of the user and the upper end (8) of which insert reaches as far as the foot area (6) of the user and the upper end (8) of which is permanently connected or can be detachably connected to the trouser leg (2,3) on the inside, wherein the connection at the upper end (8) is closed circumferentially to prevent passage of the pest through connection (9).

Abstract: The present invention relates to pharmaceutical compositions comprising a therapeutically effective dose of an isolated interferon (IFN) or IFN mutein for treatment of cardiomyopathy and of endothelial dysfunction, and to methods of treating cardiomyopathy and methods of treating endothelial dysfunction using such pharmaceutical compositions. Particularly, the pharmaceutical compositions of the present invention comprise a therapeutically effective dose of an isolated, human IFN, or IFN mutein that is a variant of an isolated human IFN, e.g., an isolated, native, human IFN? or an isolated, native, human IFN?.