Patents by Inventor Uwe Michaelis

Uwe Michaelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9821043
    Abstract: The present invention relates to parvovirus mutated structural proteins comprising insertions of mimotopes of a HER2, compositions, multimeric structures, medicaments and vaccines comprising the same, nucleic acids, expression cassettes, constructs, vectors and cells comprising the nucleic acids, methods of preparing the structural proteins and methods of inducing a B-cell response or of treating a HER2-related disease.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: November 21, 2017
    Assignee: Medigene AG
    Inventors: Uwe Michaelis, Erika Jensen-Jarolim, Christoph Rehfuess, Margit Weghofer
  • Patent number: 9402144
    Abstract: An apparatus for changing an audio scene has a direction determiner and an audio scene processing apparatus. The audio scene has at least one audio object having an audio signal and associated meta data. The direction determiner determines a direction of a position of the audio object with respect to a reference point based on the meta data of the audio object. Further, the audio scene processing device processes the audio signal, a processed audio signal derived from the audio signal or the meta data of the audio object based on a determined directional function and the determined direction of the position of the audio object.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: July 26, 2016
    Assignee: IOSONO GmbH
    Inventors: Frank Melchior, Robert Steffens, Andreas Partzsch, Uwe Michaelis
  • Patent number: 9238021
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: January 19, 2016
    Assignee: Medigene AG
    Inventors: Carsten Mundus, Christian Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Publication number: 20150238585
    Abstract: The present invention relates to parvovirus mutated structural proteins comprising insertions of mimotopes of a HER2, compositions, multimeric structures, medicaments and vaccines comprising the same, nucleic acids, expression cassettes, constructs, vectors and cells comprising the nucleic acids, methods of preparing the structural proteins and methods of inducing a B-cell response or of treating a HER2-related disease.
    Type: Application
    Filed: September 14, 2012
    Publication date: August 27, 2015
    Inventors: Uwe Michaelis, Erika Jensen-Jarolim, Christoph Rehfuess, Margit Weghofer
  • Publication number: 20140205657
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 24, 2014
    Applicant: MEDIGENE AG
    Inventors: Carsten MUNDUS, Christian WELZ, Oliver SCHRAMEL, Heinrich HAAS, Thomas FICHERT, Brita SCHULZE, Toralf PEYMANN, Uwe MICHAELIS, Michael TEIFEL, Friedrich GRUBER, Gerhard WINTER
  • Patent number: 8663606
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: March 4, 2014
    Assignee: Medigene AG
    Inventors: Carsten Mundus, Christian Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Publication number: 20120087975
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Application
    Filed: October 21, 2011
    Publication date: April 12, 2012
    Applicant: MEDIGENE AG
    Inventors: Carsten Mundus, Christian Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Patent number: 8075913
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: December 13, 2011
    Assignee: MediGene AG
    Inventors: Carsten Mundus, Christian Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Publication number: 20110038926
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Application
    Filed: August 18, 2010
    Publication date: February 17, 2011
    Inventors: Carsten Mundus, Christain Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Patent number: 7794747
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: September 14, 2010
    Assignee: Medigene Oncology GmbH
    Inventors: Carsten Mundus, Christian Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Publication number: 20100178243
    Abstract: The present invention relates to a method of stabilizing a low molecular weight compound in a cationic liposome, wherein said compound has a low solubility in a lipid membrane and/or a low permeability across a lipid membrane. Preferrably, the compound is modified in order to increase lipid membrane solubility and/or lipid membrane permeability. After delivery of the cationic liposome to a target site, particularly a target site in an organism, the modification is reversed and the low molecular weight compound may enact its desired activity.
    Type: Application
    Filed: December 22, 2009
    Publication date: July 15, 2010
    Applicant: MediGene AG
    Inventors: Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel
  • Patent number: 7754788
    Abstract: The invention relates to a light plaster mixture in pasty form which has improved storage stability. This is based on a composition which contains a binder, inorganic fillers, light fillers, water and also further additives. The light plaster mixture according to the invention can be used in the form of final coats on any bases.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: July 13, 2010
    Assignee: Alsecco GmbH & Co. KG
    Inventors: Matthias Brox, Uwe Michaelis, Uwe Befurt, Holger Rettig
  • Publication number: 20090232731
    Abstract: The present invention refers to the use of cationic liposomal preparations for the treatment or diagnosis of rheumatoid arthritis or related disorders.
    Type: Application
    Filed: May 18, 2007
    Publication date: September 17, 2009
    Inventors: Martin Funk, Brita Schulze, Eric Guenzi, Uwe Michaelis, Hermann Bohnenkamp, Martin Eichhorn, Marcus Schmitt-Sody
  • Publication number: 20080063699
    Abstract: The present invention relates to the use of pharmaceutical preparations comprising paclitaxel for administration to a human patient in need thereof.
    Type: Application
    Filed: October 15, 2004
    Publication date: March 13, 2008
    Inventors: Michael Teifel, Uwe Michaelis, Birgitta Sauer, Kerstin Bartelheim, Christoph Brunner, Kurt Naujoks
  • Patent number: 7097854
    Abstract: The present invention relates to new amino alcohol derivatives, process for the production thereof and medicaments and reagents containing these compounds.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: August 29, 2006
    Assignee: MediGene Oncology GmbH
    Inventors: Walter-Gunar Friebe, Nikolaos Dimoudis, Uwe Michaelis, Bernhard Knipp
  • Publication number: 20060128736
    Abstract: The present invention relates to compositions, particularly colloidal nanoaggregates comprising the carboxylate form of a campothecin drug or a derivative thereof associated with at least one organic cationic molecule, which has a positive net charge. The composition or nanoaggregate may be present as an emulsion, droplet, mincelle, liposome, nanoparticle or nanocapsule.
    Type: Application
    Filed: June 26, 2003
    Publication date: June 15, 2006
    Inventors: Heinrich Haas, Brita Schulze, Uwe Michaelis, Michael Teifel, Birgitta Sauer, Thomas Fichert
  • Publication number: 20050202076
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Application
    Filed: December 22, 2004
    Publication date: September 15, 2005
    Inventors: Carsten Mundus, Christain Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Publication number: 20050181038
    Abstract: The present invention relates to a method of stabilizing a low molecular weight compound in a cationic liposome, wherein said compound has a low solubility in a lipid membrane and/or a low permeability across a lipid membrane. Preferrably, the compound is modified in order to increase lipid membrane solubility and/or lipid membrane permeability. After delivery of the cationic liposome to a target site, particularly a target site in an organism, the modification is reversed and the low molecular weight compound may enact its desired activity.
    Type: Application
    Filed: December 22, 2004
    Publication date: August 18, 2005
    Inventors: Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel
  • Publication number: 20030236266
    Abstract: The present invention concerns new amino alcohol derivatives, a process for their production as well as pharmaceutical preparations and reagents which contain these substances.
    Type: Application
    Filed: January 31, 2002
    Publication date: December 25, 2003
    Applicant: Roche Diagnostics GmbH
    Inventors: Walter-Gunar Friebe, Nikolaos Dimoudis, Uwe Michaelis, Bernhard Knipp
  • Publication number: 20020034537
    Abstract: Methods and associated compositions are described for enhancing the selective delivery of therapeutic, diagnostic and imaging agents to activated vascular sites.
    Type: Application
    Filed: May 3, 2001
    Publication date: March 21, 2002
    Inventors: Brita Schulze, Birgitta Sauer, Marc Dellian, Uwe Michaelis, Michael Teifel, Kurt W. Naujoks, Claudia Biro