Patents by Inventor Uwe Ries

Uwe Ries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8420809
    Abstract: The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R3 denotes hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, O—C1-4-alkylene-COO—C1-4-alkyl.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: April 16, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thomas Krueger, Uwe Ries, Juergen Schnaubelt, Werner Rall, Zeno A. Leuter, Adil Duran, Rainer Soyka
  • Publication number: 20110124859
    Abstract: The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R3 denotes hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, O—C1-4-alkylene-COO—C1-4-alkyl.
    Type: Application
    Filed: February 7, 2011
    Publication date: May 26, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Thomas KRUEGER, Uwe RIES, Juergen SCHNAUBELT, Werner RALL, Zeno A. LEUTER, Adil DURAN, Rainer SOYKA
  • Patent number: 7939658
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym? may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: May 10, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Ries, Peter Sieger
  • Publication number: 20100152439
    Abstract: The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereof, which may be prepared starting from compounds of general formula II wherein R1 is defined as in claim 1.
    Type: Application
    Filed: February 23, 2010
    Publication date: June 17, 2010
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Guenther HUCHLER, Werner RALL, Uwe RIES
  • Patent number: 7696346
    Abstract: The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereof, which may be prepared starting from compounds of general formula II wherein R1 is defined as in claim 1.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: April 13, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guenther Huchler, Werner Rall, Uwe Ries
  • Patent number: 7638625
    Abstract: The present invention relates to the new crystalline compounds A of general formula I wherein A1, A2, A3, X, Y1, Y2 and Y3 are defined as in claim 1, and which are present in the form of their physiologically acceptable salts with acids, the acids being selected from the group B comprising hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, benzenesulphonic acid, p-toluenesulphonic acid, maleic acid, succinic acid, fumaric acid, D-(?)-tartaric acid, L-(+)-tartaric acid, naphthalene-2-sulphonic acid and naphthalene-1,5-disulphonic acid, and the polymorphs, the corresponding solvates and hydrates thereof.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: December 29, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Ries, Guenther Huchler, Sonja Sproll, Ulrike Werthmann, Andreas Zopf
  • Publication number: 20090306068
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym? may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Application
    Filed: April 7, 2009
    Publication date: December 10, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Uwe RIES, Peter SIEGER
  • Publication number: 20090181958
    Abstract: The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula wherein B, X1 to X3 and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Application
    Filed: July 21, 2008
    Publication date: July 16, 2009
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Henning Priepke, Roland Pfau, Kai Gerlach, Uwe Ries, Wolfgang Wienen, Eckhart Bauer, Herbert Nar
  • Patent number: 7534789
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym? may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: May 19, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Ries, Peter Sieger
  • Publication number: 20090022686
    Abstract: The present invention relates to the use of certain benzimidazoles for preparing a pharmaceutical composition for the treatment of systemic inflammatory response syndrome and particularly sepsis.
    Type: Application
    Filed: September 26, 2008
    Publication date: January 22, 2009
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Uwe RIES, Wolfgang WIENEN, Uwe SCHUEHLY
  • Patent number: 7429597
    Abstract: The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula wherein B, X1 to X3 and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: September 30, 2008
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Henning Priepke, Roland Pfau, Kai Gerlach, Uwe Ries, Wolfgang Wienen, Eckhart Bauer, Herbert Nar
  • Patent number: 7425641
    Abstract: The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: September 16, 2008
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Henning Priepke, Armin Heckel, Herbert Nar, Wolfgang Wienen, Jean Marie Stassen
  • Publication number: 20080086003
    Abstract: The present invention relates to the new crystalline compounds A of general formula I wherein A1, A2, A3, X, Y1, Y2 and Y3 are defined as in claim 1, and which are present in the form of their physiologically acceptable salts with acids, the acids being selected from the group B comprising hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, benzenesulphonic acid, p-toluenesulphonic acid, maleic acid, succinic acid, fumaric acid, D-(?)-tartaric acid, L-(+)-tartaric acid, naphthalene-2-sulphonic acid and naphthalene-1,5-disulphonic acid, and the polymorphs, the corresponding solvates and hydrates thereof.
    Type: Application
    Filed: April 12, 2007
    Publication date: April 10, 2008
    Inventors: Uwe RIES, Guenther HUCHLER, Sonja SPROLL, Ulrike WERTHMANN, Andreas ZOPF
  • Publication number: 20080045705
    Abstract: The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the solvates thereof, which may be prepared starting from compounds of general formula II wherein R1 is defined as in claim 1.
    Type: Application
    Filed: August 17, 2007
    Publication date: February 21, 2008
    Inventors: Guenther Huchler, Werner Rall, Uwe Ries
  • Publication number: 20070249595
    Abstract: The present invention relates to enantiomerically pure compounds of formula 1 wherein the groups m, n, B, X, R1, m and Ym- may have the meanings given in the claims and specification, methods for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Application
    Filed: March 15, 2007
    Publication date: October 25, 2007
    Inventors: Uwe RIES, Peter SIEGER
  • Publication number: 20070088160
    Abstract: The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R3 denotes hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, O—C1-4-alkylene-COO—C1-4-alkyl.
    Type: Application
    Filed: August 10, 2006
    Publication date: April 19, 2007
    Inventors: Thomas KRUEGER, Uwe Ries, Juergen Schnaubelt, Werner Rall, Zeno Leuter, Adil Duran, Rainer Soyka
  • Patent number: 7005437
    Abstract: The present invention relates to new substituted aryl and heteroaryl derivatives of general formula wherein A, Ar, n, X, Y1, Y2, Y3, Y4, R1 and R5 are defined as in claim 1, the prodrugs, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. Thus, the compounds of the above general formula I wherein R5 does not contain a cyano group have, in particular, an antithrombotic effect and a selective factor Xa-inhibiting effect with generally improved compatibility. The compounds of the above general formula I wherein R5 contains a cyano group are valuable intermediate products for preparing the antithrombotic compounds of general formula I.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: February 28, 2006
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Uwe Ries, Herbert Nar, Wolfgang Wienen, Jean-Marie Stassen
  • Publication number: 20050107409
    Abstract: The present invention relates to new aromatic bicyclic compounds of general formula wherein Ar, X, Y and Z and R1 to R3 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof, the prodrugs thereof and the salts thereof, as well as their preparation and their use as pharmaceutical compositions. The compounds of the above general formula I have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Application
    Filed: February 23, 2004
    Publication date: May 19, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Henning Priepke, Uwe Ries, Herbert Nar, Kai Gerlach, Roland Pfau, Georg Dahmann, Wolfgang Wienen
  • Publication number: 20050065346
    Abstract: The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 24, 2005
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Henning Priepke, Armin Heckel, Herbert Nar, Wolfgang Wienen, Jean Marie Stassen
  • Patent number: 6838565
    Abstract: Carboxylic acid amides of general formula having an antithrombotic activity and a factor Xa-inhibiting activity. Exemplary are: (a) N-[1-(3-amidino-phenyl)-2-(1H-tetrazol-5-yl)-ethyl]-4-(2,5-dihydro-pyrrol-1-yl-carbonyl)-3-methyl-benzamide, (b) N-[1-(3-amidino-phenyl)-2-(1H-tetrazol-5-yl)-ethyl]-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-benzamide, (c) N-[1-(5-amidino-2-hydroxy-phenyl)-2-phenyl-ethyl]-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-benzamide, and (d) N-[1-(5-amidino-2-hydroxy-phenyl)-2-(pyridin-3-yl)-ethyl]-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-benzamide.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: January 4, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Uwe Ries, Henning Priepke, Wolfgang Wienen, Herbert Nar, Sandra Handschuh